This study analyzes and optimizes the key structural components of a handling manipulator based on fatigue simulation and finite element simulation methods. Taking the handling manipulator as the research object, the structural design scheme of the manipulator is optimized based on the morphological matrix method. The key structural components of the handling manipulator are analyzed by fatigue simulation and finite element simulation methods to verify the accuracy of the theoretical derivation. The results show that the computer-controlled flatbed manipulator is the best design scheme, and the fatigue value of the gear transmission method is smaller, the stress value of the clamping claw mechanism is smaller, and the stress distribution is more uniform, with a maximum stress of 47.5 N/mm2.The proposed manipulator can effectively prolong its working life, and lays a theoretical foundation for the optimization of the manipulator's structural design and mechanical properties.