2001
DOI: 10.1152/jappl.2001.90.2.670
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Training affects muscle phospholipid fatty acid composition in humans

Abstract: Training improves insulin sensitivity, which in turn may affect performance by modulation of fuel availability. Insulin action, in turn, has been linked to specific patterns of muscle structural lipids in skeletal muscle. This study investigated whether regular exercise training exerts an effect on the muscle membrane phospholipid fatty acid composition in humans. Seven male subjects performed endurance training of the knee extensors of one leg for 4 wk. The other leg served as a control. Before, after 4 days,… Show more

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Cited by 124 publications
(103 citation statements)
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References 49 publications
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“…As a similar relationship was not found on days 8 and 14, it is evident that an increase in long-chain PUFAs in the muscle membrane cannot be a major determinant of leg glucose uptake but possibly a significant contributor. However, our finding of a significant relationship between content of long-chain PUFAs in the membrane and leg glucose uptake after 30 days of training is supported by data from two studies in which changes in membrane phospholipid fatty acid composition were present after 6 weeks of low-intensity exercise training (3) or 4 weeks of one-leg knee extensor training (4). In these studies, training induced an increase in the muscle membrane phospholipid fatty acid fraction of oleic acid (18:1n-9) and an increased fraction of PUFAs (3,4).…”
Section: Training Insulin Sensitivity and Structural Muscle Lipidssupporting
confidence: 75%
See 1 more Smart Citation
“…As a similar relationship was not found on days 8 and 14, it is evident that an increase in long-chain PUFAs in the muscle membrane cannot be a major determinant of leg glucose uptake but possibly a significant contributor. However, our finding of a significant relationship between content of long-chain PUFAs in the membrane and leg glucose uptake after 30 days of training is supported by data from two studies in which changes in membrane phospholipid fatty acid composition were present after 6 weeks of low-intensity exercise training (3) or 4 weeks of one-leg knee extensor training (4). In these studies, training induced an increase in the muscle membrane phospholipid fatty acid fraction of oleic acid (18:1n-9) and an increased fraction of PUFAs (3,4).…”
Section: Training Insulin Sensitivity and Structural Muscle Lipidssupporting
confidence: 75%
“…The incorporation of fatty acids into the muscle membrane in humans is influenced by the dietary fatty acid profile and dietary fat content per se (1,2). However, the composition of the phospholipid fatty acids in muscle membranes can also be modulated by endurance training (3,4). In parallel, endurance training leads to an improved insulin sensitivity of the skeletal muscle (5-7).…”
Section: Jørn W Helge and Flemming Delamentioning
confidence: 99%
“…Szabó et al (2002), however, observed that exercise increased the proportion of oleic acid in muscles of rabbits. Similar findings have also been published by other authors (Helge et al, 1999(Helge et al, , 2001). In the present study, the oxidation of MCFA apparently covered a higher energy requirement in more physically active rabbits reared in cages with the higher disposable space compared to rabbits reared at the higher stocking density.…”
Section: Fatty Acid Profile In Hind Leg Meatsupporting
confidence: 92%
“…In this sense, Helge [33] observed differences in phospholipid fatty acids of muscular membranes after a 4 week training period. Andersson [38] reported modifications in several fatty acids as a consequence of a 10-week training period.…”
Section: Discussionmentioning
confidence: 96%
“…One of the factors which may influence fatty acid composition is diet [32,33]. The effects of fatty acids intake on erythrocyte membrane are well documented [34].…”
Section: Discussionmentioning
confidence: 99%