In order for higher education institutions (HEIs) in Africa to sustain higher education (HE), it is critical to re-examine leadership style and knowledge in the post-COVID-19 pandemic, especially dissemination of knowledge. Due to the effects of the pandemic on HEIs and its trajectory, this chapter is motivated to explore leadership style and knowledge in Africa's HEIs. Specifically, this chapter explores types of leadership styles and open knowledge in transforming HEIs in Africa. This chapter uses a literature review approach and content analysis. One of the findings of this chapter is that there are varying dynamics and evolution in transforming HEIs in Africa particularly from an open knowledge approach. The implication is for HEI experts and stakeholders to instill HE for societal good in transforming HEIs in Africa that focuses on open knowledge approach particularly in the post-COVID-19 pandemic so that HEIs are not only providing HE but HE for good.