Trait impulsivity in female patients with borderline personality disorder and matched controls

Mortensen, Jørgen Assar; Rasmussen, Lnge Andre; Håberg, Asta

doi:10.1111/j.1601-5215.2010.00468.x

Cited by 23 publications

(21 citation statements)

References 46 publications

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“…Considering impulsivity like an imbalance between failure of 'top-down' control systems in (dorsolateral) prefrontal cortex (DLPFC) (39) and hyper-responsivity of limbic regions (37), we can reasonably hypothesise that the functionality of DLPFC and hippocampus may be altered in BPD resulting in impaired working memory and impulsivity (40). Considering impulsivity like an imbalance between failure of 'top-down' control systems in (dorsolateral) prefrontal cortex (DLPFC) (39) and hyper-responsivity of limbic regions (37), we can reasonably hypothesise that the functionality of DLPFC and hippocampus may be altered in BPD resulting in impaired working memory and impulsivity (40).…”

Section: Discussionmentioning

confidence: 99%

Impaired working memory and normal sustained attention in borderline personality disorder

Lazzaretti

Morandotti

Sala

et al. 2012

Acta Neuropsychiatr.

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P. Impaired working memory and normal sustained attention in borderline personality disorder.Objective: Although reports in the literature describe deficits in working memory in borderline personality disorder (BPD), the evidence is limited and inconsistent. The aim of this study was to evaluate further this cognitive dimension and its clinical correlates in BPD. Method: We compared the performance of 15 BPD patients to 1:1 matched healthy controls on verbal working memory as determined by the sequential letter N-back test and sustained attention as measured using the continuous performance test (CPT). Results: BPD patients performed significantly worse on the N-back test compared to healthy controls (p < 0.05), but not on the CPT. The N-back deficit was more pronounced and significant in the 3-back condition and inversely correlated with impulsivity. Conclusions: These results suggest the presence of working memory deficits in BPD that may be linked to greater impulsivity and sustained by impairment in the dorsolateral prefrontal cortex.

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Section: Discussionmentioning

confidence: 99%

Impaired working memory and normal sustained attention in borderline personality disorder

Lazzaretti

Morandotti

Sala

et al. 2012

Acta Neuropsychiatr.

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“…The EIS was originally developed on a sample that included 787 (66% of the sample) female adult subjects and the data showed no sex differences on impulsiveness (Eysenck & Eysenck, 1978). The EIS has been shown to correlate negatively with activity in the left orbitofrontal cortex, amygdala and precuneus, and bilaterally in the cingulate cortices during response inhibition on a sample of women with borderline personality disorder and matched controls (Mortensen, Rasmussen, & Haberg, 2010). A study of 100 female prisoners found positive relationships between substance use severity and EIS scores (Mooney et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

Impulsiveness, and trait displaced aggression among drug using female sex traders

Clingan

Fisher

Pedersen

et al. 2016

Addictive Behaviors

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Objective This study compared women who sex trade for drugs, money, or both compared to neither (did not sex trade), and introduced the concept of trait displaced aggression to the literature on sex trading. Methods Female participants (n = 1055) were recruited from a low-income area of southern California. Measures included: the Risk Behavior Assessment (RBA), Barratt Impulsivity Scale (BIS), Eysenck Impulsiveness Scale (EIS), and the Displaced Aggression Questionnaire (DAQ). Results Women who traded sex for both drugs and money used crack cocaine, powder cocaine, and alcohol significantly more, scored higher on the BIS, and the EIS, and were significantly older. Those who only sex traded for drugs used more amphetamine, heroin, and injected drugs more days. They were also higher on the DAQ and all of the DAQ subscales. Those who traded for money only used marijuana more and were more likely to use marijuana before sex. Conclusions This study may help address specific issues unique to those who sex trade for different commodities in that the drugs used are different and the underlying personality characteristics are different.

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“…An fMRI study in BPD patients compared to NPC showed a negative correlation between the number of commission errors and activation in the medial frontal gyrus, anterior cingulate cortex (ACC), temporal gyrus and striatum (Leyton et al 2001). Two other fMRI studies did not show any differences in brain activity between BPD and NPC (Mortensen et al 2010;van Eijk et al 2015).…”

Section: Introductionmentioning

confidence: 97%

Impulse control under emotion processing: an fMRI investigation in borderline personality disorder compared to non-patients and cluster-C personality disorder patients

Zutphen

Siep

Jacob

et al. 2019

Brain Imaging and Behavior

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Impulsivity is a characteristic syndromal and neurobehavioral feature of borderline personality disorder (BPD). Research suggests an important interaction between high negative emotions and low behavioral inhibition in BPD. However, knowledge about the generalizability across stimulus categories and diagnosis specificity is limited. We investigated neural correlates of hypothesized impaired response inhibition of BPD patients to negative, positive and erotic stimuli, by comparing them to non-patients and cluster-C personality disorder patients. During fMRI scanning, 53 BPD patients, 34 non-patients and 20 cluster-C personality disorder patients completed an affective go/no-go task, including social pictures. BPD patients showed more omission errors than non-patients, independent of the stimulus category. Furthermore, BPD patients showed higher activity in the inferior parietal lobule and frontal eye fields when inhibiting negative versus neutral stimuli. Activity of the inferior parietal lobule correlated positively with the BPD checklist subscale impulsivity. When inhibiting emotional stimuli, BPD patients showed an altered brain activity in the inferior parietal lobe and frontal eye fields, whereas previously shown dysfunctional prefrontal activity was not replicated. BPD patients showed a general responsivity across stimulus categories in the frontal eye fields, whereas effects in the inferior parietal lobe were specific for negative stimuli. Results of diagnosis specificity support a dimensional rather than a categorical differentiation between BPD and cluster-C patients during inhibition of social emotional stimuli. Supported by behavioral results, BPD patients showed no deficiencies in emotionally modulated response inhibition per se but the present findings rather hint at attentional difficulties for emotional information.

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Trait impulsivity in female patients with borderline personality disorder and matched controls

Abstract: These results imply that successful impulse inhibition involves interaction between the impulsive and the emotional systems. Furthermore, impulsivity in BPD is described as rash impulsivity, coexisting with increased SP.

Cited by 23 publications

References 46 publications

Impaired working memory and normal sustained attention in borderline personality disorder

Impaired working memory and normal sustained attention in borderline personality disorder

Impulsiveness, and trait displaced aggression among drug using female sex traders

Impulse control under emotion processing: an fMRI investigation in borderline personality disorder compared to non-patients and cluster-C personality disorder patients

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