Traitement par propranolol des hémangiomes infantiles

Léauté‐Labrèze, Christine

doi:10.1016/j.arcped.2015.01.001

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…We have noted a ubiquitous distribution of lesions, as reported by some authors with, however, as in our series a cephalic predominance [12,18,19]. From the therapeutic point of view, since the observation of their effectiveness, betablockers are the subject of several studies [20][21][22][23]. In our study we noted a remarkable efficacy of Propranolol in 93.3% after 24 months of treatment.…”

Section: Discussionsupporting

confidence: 57%

Management of hemangiomas by propranolol: Epidemiological, clinical and therapeutic aspects: retrospective study about 15 cases

Doulla¹,

Bako²,

Salissou³

et al. 2018

Our Dermatol Online

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The objective of this study was to determine the epidemiological, clinical and therapeutic profile of cutaneous hemangioma at the Niamey National Hospital. This is a retrospective study carried out over a period of 2 years, in the Unity of Dermatology and Venerology. Out of a total of 1648 consultations in 2 years, 33 cases of cutaneous angioma were identified; which represented 2%. The prevalence was predominantly female (80%) and the sex ratio M/F was 0.25. The age group 0-5 months was more represented (66.7%) with ages ranging 2 days and 24 months. Of the 33 cases of angioma, 25 were hemangiomas and 8 were malformations without any cardiac anomalie. Patients retained for the study were those with hemangioma (25 cases with 76%) who received the Propranolol protocol used in the oral dosage of 1 mg/kg/day for 24 months. Only 15 patients recovered totally from hemangioma. Tolerance was good in 93.3%. Conclusion: Several therapies still show their limit. Due to the often serious side effects with corticosteroids, treatment based on betablockers can be a way of the future, given the satisfaction of results and the good tolerance to these molecules.

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Section: Discussionsupporting

confidence: 57%

Management of hemangiomas by propranolol: Epidemiological, clinical and therapeutic aspects: retrospective study about 15 cases

Doulla¹,

Bako²,

Salissou³

et al. 2018

Our Dermatol Online

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“…Propranolol is one of the newest proposed treatments for ROP despite weak and contradictory animal preclinical data Propranalol is a nonselective β-adrenoreceptor blocker shown to reduce the growth of infantile capillary haemangiomas (106). The mechanism of action is likely due to suppression of VEGF.…”

Section: Pharmacologic Interventions In Ropmentioning

confidence: 99%

Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

Beharry

Valencia

Lazzaro

et al. 2016

Seminars in Perinatology

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Retinopathy of prematurity (ROP), a significant morbidity in prematurely born infants, is the most common cause of visual impairment and blindness in children and persists till adulthood. Strict control of oxygen therapy and prevention of intermittent hypoxia are key in the prevention of ROP, but pharmacologic interventions have decreased risk of ROP. Various drug classes such as methylxanthines (caffeine), VEGF inhibitors, anti-oxidants, and others have decreased ROP occurrence. The timing of pharmacologic intervention remains unsettled, but early prevention rather than controlling disease progression may be preferred. These drugs act through different mechanisms and synergistic approaches should be considered to maximize efficacy and safety.

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Dermatologia pediatrica

Léauté‐Labrèze

2017

EMC - AKOS - Trattato di Medicina

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Traitement par propranolol des hémangiomes infantiles

Cited by 8 publications

References 16 publications

Management of hemangiomas by propranolol: Epidemiological, clinical and therapeutic aspects: retrospective study about 15 cases

Management of hemangiomas by propranolol: Epidemiological, clinical and therapeutic aspects: retrospective study about 15 cases

Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

Dermatologia pediatrica

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