Trajectories of Fatigue in Patients With Breast Cancer Before, During, and After Radiation Therapy

Dhruva, Anand; Dodd, Marylin; Paul, Steven M.; Cooper, Bruce A.; Lee, Kathryn; West, Claudia; Aouizerat, Bradley E.; Swift, Patrick S.; Wara, William; Miaskowski, Christine

doi:10.1097/ncc.0b013e3181c75f2a

Cited by 121 publications

(194 citation statements)

References 52 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…49–52 A cutoff score of ≥4.4 indicates high levels of fatigue. 24 A cutoff score of ≤4.8 indicates low levels of energy. 24 The LFS has well established validity and reliability.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Predictors of Initial Levels and Trajectories of Anxiety in Women Before and for 6 Months After Breast Cancer Surgery

et al. 2014

Self Cite

View full text Add to dashboard Cite

Background The diagnosis of breast cancer in combination with the anticipation of surgery evokes fear, uncertainty, and anxiety in most women. Objective In patients who underwent breast cancer surgery, study purposes were to examine how ratings of state anxiety changed from the time of the preoperative assessment to 6 months after surgery and to investigate whether specific demographic, clinical, symptom, and psychosocial adjustment characteristics predicted the preoperative levels of state anxiety and/or characteristics of the trajectories of state anxiety. Interventions/Methods Patients (n=396) were enrolled preoperatively and completed the Spielberger State Anxiety inventory monthly for six months. Using hierarchical linear modeling, demographic, clinical, symptom, and psychosocial adjustment characteristics were evaluated as predictors of initial levels and trajectories of state anxiety. Results Patients experienced moderate levels of anxiety prior to surgery. Higher levels of depressive symptoms and uncertainty about the future, as well as lower levels of life satisfaction, less sense of control, and greater difficulty coping predicted higher preoperative levels of state anxiety. Higher preoperative state anxiety, poorer physical health, decreased sense of control, and more feelings of isolation predicted higher state anxiety scores over time. Conclusions Moderate levels of anxiety persist in women for six months following breast cancer surgery. Implications for Practice Clinicians need to implement systematic assessments of anxiety to identify high risk women who warrant more targeted interventions. In addition, ongoing follow-up is needed in order to prevent adverse postoperative outcomes and to support women to return to their preoperative levels of function.

show abstract

“…49–52 A cutoff score of ≥4.4 indicates high levels of fatigue. 24 A cutoff score of ≤4.8 indicates low levels of energy. 24 The LFS has well established validity and reliability.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, newer methods of longitudinal data analysis (e.g., hierarchical linear modeling (HLM)) can be used to identify predictors of initial levels and trajectories of anxiety. 24,25 …”

Section: Introductionmentioning

confidence: 99%

Predictors of Initial Levels and Trajectories of Anxiety in Women Before and for 6 Months After Breast Cancer Surgery

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Depressão também foi fator preditor de fadiga em outros estudos em pacientes com câncer de mama (5,22).…”

Section: Discussionunclassified

“…Apesar da elevada prevalência de fadiga nas pacientes com prejuízo do sono, no presente estudo, a variável não se manteve no modelo. Contudo, sono foi preditor de fadiga em outras publicações em mulheres com câncer de mama (18,22).…”

Section: Discussionunclassified

Fadiga clinicamente relevante em mulheres com câncer de mama: prevalência e fatores associados

Lamino

Pimenta²,

Braga³

et al. 2014

Investg. Enferm. Imagen Desarollo.

View full text Add to dashboard Cite

Introducción: La fatiga es un síntoma frecuente en pacientes con cáncer. Objetivo: Examinarla prevalencia y los predictores independientes de la fatiga en las mujeres concáncer de mama. Material e método: Se trata de un estudio transversal con una muestrano probabilística de 163 pacientes en acompañamiento ambulatorio. La fatiga fueevaluada por la Escala de Fatiga de Piper. Resultados: La fatiga clínicamente relevante(puntuación ≥ 4) estuvo presente en el 31,9 % de la muestra y la intensidad media fue de6 (DP = 1,3). El dolor y la depresión fueron factores independientemente asociados conla fatiga. Conclusiones: La asociación de la fatiga, el dolor y la depresión confirmaron la existencia de clúster de síntomas. El control de la fatiga es poco conocido, pero la depresión y el dolor pueden ser tratados y tal vez proporcionar alivio de la fatiga.

show abstract

“…The prevalence and severity of fatigue is slightly different in cancer patients receiving varying treatments [18]. RIF has been noted to increase slightly beginning at week 3 of treatment, then worsen significantly in severity by week 6 of RT, remaining elevated following the completion of treatment [14,19–21]. RIF is a distressing and highly prevalent symptom experienced by cancer patients during RT.…”

Section: Rifmentioning

confidence: 99%

The Etiology and management of radiotherapy-induced fatigue

Hsiao

Daly

Saligan

2016

Expert Review of Quality of Life in Cancer Care

View full text Add to dashboard Cite

Fatigue is one of the most common side-effects accompanying radiotherapy, but arguably the least understood. Radiotherapy-induced fatigue (RIF) is a clinical subtype of cancer treatment-related fatigue. It is described as a pervasive, subjective sense of tiredness persisting over time, interferes with activities of daily living, and is not relieved by adequate rest or sleep. RIF is one of the early side-effects and long-lasting for cancer patients treated with localized radiation. Although the underlying mechanisms of fatigue have been studied in several disease conditions, the etiology, mechanisms, and risk factors of RIF remain elusive, and this symptom remains poorly managed. The purpose of this paper is to review and discuss recent articles that defined, proposed biologic underpinnings and mechanisms to explain the pathobiology of RIF, as well as articles that proposed interventions to manage RIF. Understanding the mechanisms of RIF can describe promising pathways to identify at-risk individuals and identify potential therapeutic targets to alleviate and prevent RIF using a multimodal, multidisciplinary approach.

show abstract

Trajectories of Fatigue in Patients With Breast Cancer Before, During, and After Radiation Therapy

Abstract: Background-Fatigue is a significant problem associated with radiation therapy (RT).

Cited by 121 publications

References 52 publications

Predictors of Initial Levels and Trajectories of Anxiety in Women Before and for 6 Months After Breast Cancer Surgery

Predictors of Initial Levels and Trajectories of Anxiety in Women Before and for 6 Months After Breast Cancer Surgery

Fadiga clinicamente relevante em mulheres com câncer de mama: prevalência e fatores associados

The Etiology and management of radiotherapy-induced fatigue

Contact Info

Product

Resources

About