Trajectories of medication adherence in patients with Bipolar Disorder along 2 years-follow-up

Consoloni, Julia-Lou; M’Baïlara, Katia; Perchec, Cyrille; Aouizerate, Bruno; Aubin, V.; Azorin, Jean‐Michel; Bellivier, Frank; Corréard, N.; Courtet, Philippe; Dubertret, Caroline; Étain, Bruno; Gard, Sébastien; Haffen, Emmanuel; Leboyer, Marion; Llorca, Pierre‐Michel; Olié, Émilie; Polosan, Mircea; Roux, Paul; Schwan, Raymund; Samalin, Ludovic; Belzeaux, Raoul

doi:10.1016/j.jad.2020.12.192

Cited by 16 publications

(16 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These clinical characteristics were found to be associated with polySUD not only in the univariate but also in the multinomial regression analysis. It is well-known that psychotic and residual symptoms exert a negative impact on the functioning, quality of life, and adherence to treatment in patients with BD ( 46 – 49 ). The relationship between psychotic symptoms and illicit substances in BD could be bidirectional.…”

Section: Discussionmentioning

confidence: 99%

Bipolar Disorder and Polysubstance Use Disorder: Sociodemographic and Clinical Correlates

Aguglia

Natale²,

Fusar-Poli³

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

IntroductionPatients with bipolar disorder (BD) often show comorbidity with substance use disorder (SUD) with a negative impact on clinical course, prognosis, and functioning. The role of polysubstance use disorder (polySUD) is understudied. The aim of the present paper is to evaluate the sociodemographic and clinical characteristics associated with BD and comorbid SUD, focusing on polySUD, in order to phenotype this specific group of patients and implement adequate treatment and prevention strategies.MethodsA cross-sectional study was conducted involving 556 patients with a primary diagnosis of BD (376 without SUD, 101 with SUD, and 79 with polySUD). A semi-structured interview was administered to collect sociodemographic variables, clinical characteristics, and pharmacological treatment. ANOVA and chi-square tests were used to compare the three groups. Significantly different variables were then inserted in multivariate logistic regression.ResultsPatients affected by BD and polySUD were younger, and more frequently males and single, than patients with SUD or without SUD. Indeed, the prevalence of patients affected by BD and polySUD living in residential facilities was higher than in the other groups. Moreover, earlier age at onset, higher prevalence of psychotic and residual symptoms, involuntary hospitalization, and a family history of psychiatric disorders were associated with polySUD in patients suffering from BD. Lastly, patients with BD and polySUD were more likely to take four or more medications, particularly benzodiazepines and other drugs. At the multinomial regression, younger age, male gender, early age at onset, psychotic and residual symptoms, positive family history of psychiatric disorders, and use of benzodiazepines remained significantly associated with polySUD in patients with BD.ConclusionOur findings show a specific profile of patients with BD and polySUD. It is important to conduct research on this topic in order to adopt specific therapeutic strategies, minimize the use of polypharmacy, and aim at full remission and mood stabilization.

show abstract

Section: Discussionmentioning

confidence: 99%

Bipolar Disorder and Polysubstance Use Disorder: Sociodemographic and Clinical Correlates

Aguglia

Natale²,

Fusar-Poli³

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Regarding adherence to medication, we identified three distinct trajectories: one trajectory starts poorly and keeps deteriorating (4.8%); one trajectory starts poorly but improves (9%); and the last one starts well and keeps improving (86.2%). A good tolerance to psychotropic medications, low depressive symptoms, and prescription of anticonvulsants were associated with better adherence 36 .…”

Section: Prediction Of Outcomes: Bd Course and Trajectoriesmentioning

confidence: 96%

Key findings on bipolar disorders from the longitudinal FondaMental Advanced Center of Expertise-Bipolar Disorder (FACE-BD) cohort

Aubin¹,

Belzeaux²,

Costagliola³

et al. 2022

Journal of Affective Disorders

Self Cite

View full text Add to dashboard Cite

“…Several factors have been associated with lower adherence, including younger patient age, first year of treatment, poor medication tolerability, and more severe depressive symptoms. 44,45 Lower medication adherence has been associated with adverse outcomes, including greater risk of suicidality and hospitalization. 46 Treatment and Management: Acute Manic/Hypomanic Episodes Special consideration should be given to safety during evaluation.…”

Section: Treatment Adherencementioning

confidence: 99%

Treating Bipolar Disorder in Primary Care: Diagnosis, Pharmacology, and Management

Huang¹,

Nissen²,

Lim³

et al. 2022

IJGM

View full text Add to dashboard Cite

Bipolar disorder is a chronic mental illness associated with early mortality, elevated risk of comorbid cardiovascular disease, enormous burden of disability, and large societal costs. Patients often seek treatment for symptoms of bipolar disorder in the primary care setting but are frequently misdiagnosed. This article provides primary care providers with an evidence-based approach to the screening, diagnosis, and pharmacological management of bipolar disorder. Guidance is also provided for helping patients connect with higher levels of specialty psychiatric care when clinically indicated.

show abstract

Trajectories of medication adherence in patients with Bipolar Disorder along 2 years-follow-up

Cited by 16 publications

References 28 publications

Bipolar Disorder and Polysubstance Use Disorder: Sociodemographic and Clinical Correlates

Bipolar Disorder and Polysubstance Use Disorder: Sociodemographic and Clinical Correlates

Key findings on bipolar disorders from the longitudinal FondaMental Advanced Center of Expertise-Bipolar Disorder (FACE-BD) cohort

Treating Bipolar Disorder in Primary Care: Diagnosis, Pharmacology, and Management

Contact Info

Product

Resources

About