Trajectory of leptin and leptin receptor in vertebrates: Structure, function and their regulation

Bakshi, Amrita; Singh, Rajeev; Rai, Umesh

doi:10.1016/j.cbpb.2021.110652

Cited by 20 publications

(20 citation statements)

References 255 publications

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“…Our previous study identified LEP gene as the candidate gene associated with carcass traits (Matsumoto et al, 2013). An encoded peptide hormone regulates metabolisms in various tissues (Bakshi et al, 2021), indicating that functional and/or quantitative alteration of LEP protein may affect carcass traits. Sequence comparison of CDS in LEP gene with eight Kumamoto sub-breeds of Japanese Brown cattle detected one nonsynonymous mutation and four linked synonymous mutations.…”

Section: Discussionmentioning

confidence: 99%

Leptin gene contributes to beef marbling standard, meat brightness, meat firmness, and beef fat standard of the Kumamoto sub‐breed of Japanese Brown cattle

Matsumoto

Kimura

Nagai

et al. 2022

Animal Science Journal

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The Kumamoto sub-breed of Japanese Brown cattle has unique characteristics, such as great growth rate, and their contribution as future breeding materials is expected.To develop a DNA marker for their breeding, we investigated the effects of Leptin gene, controlling energy homeostasis, on carcass traits of the Kumamoto sub-breed.Sequence comparison identified five single nucleotide polymorphisms (SNPs): four linked synonymous mutations and one nonsynonymous mutation. Statistical analysis revealed that c.239C > T (p.A80V) had significant effects on the traits related with quality grade: beef marbling standard (p = 0.0132), meat brightness (p = 0.0383), and meat firmness (p = 0.0115). The C allele showed favorable effects; these scores of the C/C cattle were significantly higher than those of the C/T cattle. On the other hand, the effect of c.399T > C was observed on meat firmness (p = 0.0172) and beef fat standards (BFS) (p = 0.0129). The C/C cattle showed higher values of these traits than the T/T cattle. Our data suggested that these SNPs in Leptin gene could be used as a DNA marker for breeding of the Kumamoto sub-breed.

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Section: Discussionmentioning

confidence: 99%

Leptin gene contributes to beef marbling standard, meat brightness, meat firmness, and beef fat standard of the Kumamoto sub‐breed of Japanese Brown cattle

Matsumoto

Kimura

Nagai

et al. 2022

Animal Science Journal

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“…In addition, early growth response 1 (Egr1), a zinc finger transcription factor of a gene family that primarily participates in differentiation, growth control, and cancer progression, is expressed in adipocytes and is rapidly induced by nutrients and insulin, through direct binding to leptin gene promoters and stimulating transcription [ 67 ]. Glucocorticoids augment leptin mRNA levels in mammals and the combination of insulin and glucocorticoids increase leptin expression synergistically in adipocyte cultures [ 68 ]. This result suggests that these hormones could be the main regulators of this adipokine in humans.…”

Section: Regulation Of Leptin Efficiencymentioning

confidence: 99%

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

Casado

Collado-Pérez

Frago

et al. 2023

IJMS

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Excess body weight is frequently associated with low-grade inflammation. Evidence indicates a relationship between obesity and cancer, as well as with other diseases, such as diabetes and non-alcoholic fatty liver disease, in which inflammation and the actions of various adipokines play a role in the pathological mechanisms involved in these disorders. Leptin is mainly produced by adipose tissue in proportion to fat stores, but it is also synthesized in other organs, where leptin receptors are expressed. This hormone performs numerous actions in the brain, mainly related to the control of energy homeostasis. It is also involved in neurogenesis and neuroprotection, and central leptin resistance is related to some neurological disorders, e.g., Parkinson’s and Alzheimer’s diseases. In peripheral tissues, leptin is implicated in the regulation of metabolism, as well as of bone density and muscle mass. All these actions can be affected by changes in leptin levels and the mechanisms associated with resistance to this hormone. This review will present recent advances in the molecular mechanisms of leptin action and their underlying roles in pathological situations, which may be of interest for revealing new approaches for the treatment of diseases where the actions of this adipokine might be compromised.

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“…Leptin regulates food intake and energy homeostasis; elevation in its levels leads to the inhibition of hypothalamic orexigenic peptides (agouti-related peptide (AgRP), and neuropeptide Y (NPY)), and the activation of anorexigenic peptides (cocaine and amphetamine-related transcript (CART) and proopiomelanocortin (POMC). It regulates lipid metabolism by enhancing lipolysis and inhibiting lipogenesis [ 31 ]. Leptin is implicated in both innate and adaptive immune responses.…”

Section: Leptin Physiologymentioning

confidence: 99%

“…Box 1 contains proline residues that are essential for the recruitment of JAK2. Box 3 has a role in the recruitment and activation of STAT3 [ 31 ]. In addition to Box regions, it contains four tyrosine residues (Tyr 974 , Tyr 985 , Tyr 1077 , and Tyr 1138 ).…”

Section: Leptin Receptorsmentioning

confidence: 99%

Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?

Eldjoudi

Cordero-Barreal

González-Rodríguez

et al. 2022

IJMS

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White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis and triglyceride storage. It is now considered as an active organ secreting a plethora of hormones and cytokines namely adipokines. Discovered in 1994, leptin has emerged as a key molecule with pleiotropic functions. It is primarily recognized for its role in regulating energy homeostasis and food intake. Currently, further evidence suggests its potent role in reproduction, glucose metabolism, hematopoiesis, and interaction with the immune system. It is implicated in both innate and adaptive immunity, and it is reported to contribute, with other adipokines, in the cross-talking networks involved in the pathogenesis of chronic inflammation and immune-related diseases of the musculo-skeletal system such as osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the most recent findings concerning the involvement of leptin in immunity and inflammatory responses in OA and RA.

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Trajectory of leptin and leptin receptor in vertebrates: Structure, function and their regulation

Cited by 20 publications

References 255 publications

Leptin gene contributes to beef marbling standard, meat brightness, meat firmness, and beef fat standard of the Kumamoto sub‐breed of Japanese Brown cattle

Leptin gene contributes to beef marbling standard, meat brightness, meat firmness, and beef fat standard of the Kumamoto sub‐breed of Japanese Brown cattle

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?

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