Tramadol Added to Mepivacaine Prolongs the Duration of an Axillary Brachial Plexus Blockade

Kapral, Stephan; Gollmann, Günter; Waltl, Barbara; Likar, Rudolf; Sladen, Robert N.; Weinstabl, C.; Lehofer, F.

doi:10.1097/00000539-199904000-00032

Cited by 96 publications

(94 citation statements)

References 9 publications

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“…12 It has been suggested that tramadol added to mepivacaine prolongs the duration of sensory and motor block of brachial plexus anesthesia. 9 In volunteers, the absence of local anesthetic effect of tramadol used as the sole agent in IVRA has been reported. 1 3 Though it was suggested in that study that tramadol added to local anesthetics might provide a significant effect on the onset and recovery of the touch sensation, similar results were not observed for pinprick and cold sensations, or for motor blockade.…”

Section: Discussionmentioning

confidence: 99%

“…7 However, recent studies suggest that tramadol might have a specific effect on peripheral nerves when used alone 8 or when added to a local anesthetic. 9 Considering a possible local analgesic effect similar to that of clonidine, 6 we conducted a prospective study to examine the effect of tramadol combined with lidocaine for IVRA on the quality of regional block and postoperative analgesia.…”

Section: Conclusion : La Combinaison De Tramadol Et De Lidocaïne Utimentioning

confidence: 99%

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The addition of tramadol to lidocaine does not reduce tourniquet and postoperative pain duringiv regional anesthesia

Langlois

Estèbe

Gentili

et al. 2002

Can J Anesth/J Can Anesth

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Purpose: We conducted a prospective, randomized, double-blind study to determine whether the combination of tramadol with lidocaine 0.5% had an analgesic effect on tourniquet pain during iv regional anesthesia and also on postoperative pain.Methods: Thirty patients scheduled for carpal tunnel decompression were included in the study. Each patient received 3 mg·kg -1 of plain lidocaine 0.5% with 100 mg of tramadol (Group T) or 2 mL of isotonic saline (Group C). The mixture was injected into the isolated and exsanguinated arm. Pain was assessed using a linear visual analog scale and a verbal rate scale during the surgical procedure and the postoperative period (240 min) and subsequently at interview at 24 hr. Analgesic consumption was recorded.Result: There was no difference in the pain scales and analgesic request at any of the time periods studied. Conclusion:We conclude, therefore, that for carpal tunnel operation under iv regional anesthesia, the combination of tramadol and lidocaine is not more effective than lidocaine alone.

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Section: Discussionmentioning

confidence: 99%

Section: Conclusion : La Combinaison De Tramadol Et De Lidocaïne Utimentioning

confidence: 99%

The addition of tramadol to lidocaine does not reduce tourniquet and postoperative pain duringiv regional anesthesia

Langlois

Estèbe

Gentili

et al. 2002

Can J Anesth/J Can Anesth

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“…After injection, the arm was kept adducted with the hand resting on the chest. Sensory and motor block assessments were evaluated before surgery according to the literature [9,13]. One of us (XS) evaluated the sensory and motor blocks of the musculocutaneous, radial, ulnar, and median nerve immediately and at 5, 10, 20, and 30 minutes after completion of the injection.…”

Section: Methodsmentioning

confidence: 99%

“…Six patients had failed blocks (two in Group A, two in Group B, and two in Group C) in our study, and received supplementary blocks (5 mL levobupivacaine 0.25%) and were excluded from the study. Motor block also was evaluated according to previous studies [9,13]. Measurements were performed using a modification of the Lovett rating scale from 6 (normal muscle force) to 0 points (complete paralysis) by extending the thumb at the interphalangeal joint (radial nerve), thumb adduction (ulnar nerve), thumb opposition (median nerve), and flexion of the elbow in supination and pronation of the forearm (musculocutaneous nerve).…”

Section: Methodsmentioning

confidence: 99%

Parecoxib Added to Ropivacaine Prolongs Duration of Axillary Brachial Plexus Blockade and Relieves Postoperative Pain

Liu

Zhao

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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Background Cyclooxygenase (COX)-2 antagonist is widely used for intravenous postoperative pain relief. Recent studies reported COX-2 in the spinal dorsal horn could modulate spinal nociceptive processes. Epidural parecoxib in rats showed no neurotoxicity. These findings suggested applying a COX-2 antagonist directly to the central or peripheral nerve might provide better analgesia. Questions/purposes We therefore determined: (1) whether the addition of parecoxib to ropivacaine injected locally on the nerve block affected the sensory and motor block times of the brachial plexus nerve block; and (2) whether parecoxib injected locally on the nerve or intravenously had a similar analgesic adjuvant effect.Methods We conducted a randomized controlled trial from January 2009 to November 2010 with 150 patients scheduled for elective forearm surgery, using a multiplenerve stimulation technique. Patients were randomly allocated into one of three groups: Group A (n = 50) received ropivacaine 0.25% alone on the brachial plexus nerve; Group B (n = 50) received ropivacaine together with 20 mg parecoxib locally on the nerve block; and Group C (n = 50) received 20 mg parecoxib intravenously. We recorded the duration of the sensory and motor blocks, and the most severe pain score during a 24-hour postoperative period.

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“…In a study conducted by Kapral et al [17], adding 100 mg tramadol to 40 ml 1 % mepivacaine in axillary brachial plexus block, it was shown that tramadol prolongs the duration of sensory and motor block without causing any significant side effects, this can be given as an example to the peripheral action of tramadol which was mentioned above.…”

Section: Discussionmentioning

confidence: 95%

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Ekmekçi

Beriat

Bengisun

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Tramadol is a centrally acting opioid which is effective for moderate-severe pain and is being used for various acute and chronic pain scenarios. The primary endpoint of this controlled, randomized double blind study was to evaluate the effect of submucosal tramadol on VAS scores after septoplasty operations and secondary endpoint was to investigate the effects on total opioid and additional analgesic consumption and patient satisfaction. 60 patients scheduled for septoplasty under general anaesthesia were enrolled. In Group T, at the end of surgery following hemostasis, 2 mg/kg tramadol was applied as submucosal infiltration to both surgical sites, 2 ml (total 4 ml), by the surgeon. In Group P, at the end of surgery following hemostasis, 2 ml isotonic solution (total 4 ml) was applied as submucosal infiltration to both surgical sites by the surgeon. Total opioid consumption, VAS scores, patient satisfaction was evaluated at the end of 24 h VAS values were higher in Group P on the first and second postoperative hours. Patient controlled analgesia demand and delivery values were higher in Group P on the postoperative 1, 2, 4, 6, 12 and 24th hours. Patient satisfaction was higher and opioid consumption was lower in Group T compared to Group P. There was no difference in additional analgesic consumption between two groups. The results show that patients receiving tramadol had lower VAS scores compared with the placebo groups postoperatively.

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Tramadol Added to Mepivacaine Prolongs the Duration of an Axillary Brachial Plexus Blockade

Abstract: This study demonstrates that the admixture of 100 mg of tramadol with mepivacaine 1% for brachial plexus block provides a pronounced prolongation of blockade without side effects. Our data support a specific analgesic effect of tramadol on peripheral nerves.

Cited by 96 publications

References 9 publications

The addition of tramadol to lidocaine does not reduce tourniquet and postoperative pain duringiv regional anesthesia

The addition of tramadol to lidocaine does not reduce tourniquet and postoperative pain duringiv regional anesthesia

Parecoxib Added to Ropivacaine Prolongs Duration of Axillary Brachial Plexus Blockade and Relieves Postoperative Pain

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

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