Tranexamic Acid in a Case Report of Life-threatening Nontraumatic Hemorrhage in Immune 
Thrombocytopenic Purpura

Randall, Melanie M; Nurse, Jason R. C.; Singh, Karan P.

doi:10.5811/cpcem.2020.5.46955

Cited by 1 publication

(1 citation statement)

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“…Antifibrinolytics (tranexamic acid and aminocaproic acid) are successfully used to control significant bleeding in patients with ITP [ 102 , 103 , 104 ]. Oral contraceptives can be used in female patients with menorrhagia.…”

Section: Treatment Of Itpmentioning

confidence: 99%

Primary Immune Thrombocytopenia: Novel Insights into Pathophysiology and Disease Management

Singh¹,

Uzun²,

Bakchoul³

2021

JCM

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Immune thrombocytopenia (ITP) is an autoimmune disorder defined by a significantly reduced number of platelets in blood circulation. Due to low levels of platelets, ITP is associated with frequent bruising and bleeding. Current evidence suggests that low platelet counts in ITP are the result of multiple factors, including impaired thrombopoiesis and variations in immune response leading to platelet destruction during pathological conditions. Patient outcomes as well as clinic presentation of the disease have largely been shown to be case-specific, hinting towards ITP rather being a group of clinical conditions sharing common symptoms. The most frequent characteristics include dysfunction in primary haemostasis and loss of immune tolerance towards platelet as well as megakaryocyte antigens. This heterogeneity in patient population and characteristics make it challenging for the clinicians to choose appropriate therapeutic regimen. Therefore, it is vital to understand the pathomechanisms behind the disease and to consider various factors including patient age, platelet count levels, co-morbidities and patient preferences before initiating therapy. This review summarizes recent developments in the pathophysiology of ITP and provides a comprehensive overview of current therapeutic strategies as well as potential future drugs for the management of ITP.

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Section: Treatment Of Itpmentioning

confidence: 99%