Tranexamic acid-loaded starch hemostatic microspheres

Su, Huantong; Wei, Shuda; Chen, Fangping; Cui, Ruihua; Liu, Changsheng

doi:10.1039/c8ra06662k

Cited by 26 publications

(12 citation statements)

References 34 publications

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“…TEG was applied to evaluate and compare the strength of clot which was mixed with sample in vitro. [ 36 ] TEG machine (TEG‐5000, Haemoscope Co., USA) was calibrated by quality control standards at 37 °C before use. 20 µL of CaCl 2 (0.2 mol L −1 ) was added to the TEG cups before adding the blood samples to overcome the anticoagulant effect.…”

Section: Methodsmentioning

confidence: 99%

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Sun

Zhang

et al. 2020

Adv Healthcare Materials

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Uncontrolled hemorrhage is the main reason of possible preventable death after accidental injury. It is necessary to develop a hemostatic agent with rapid hemostatic performance and good biocompatibility. In this study, a chitosan/diatom-biosilica-based aerogel is developed using dopamine as cross-linker by simple alkaline precipitation and tert-butyl alcohol replacement. The chitosan/diatom-biosilica aerogel exhibits favorable biocompatibility and multiscale hierarchical porous structure (from nanometer to micrometer), which can be controlled by the concentration of tert-butyl alcohol. The displacement of tert-butyl alcohol can keep the porosity of diatom-biosilica in aerogel and give it large surface with efficient water absorption ratio. 30% tert-butyl alcohol replacement of aerogel possesses the largest surface area (74.441 m 2 g −1), water absorption capacity (316.83 ± 2.04%), and excellent hemostatic performance in vitro blood coagulation (≈70 s). Furthermore, this aerogel exhibits the shortest clotting time and lowest blood loss in rat hemorrhage model. The strong interface effect between aerogel and blood is able to promote erythrocytes aggregation, platelets adhesion, and activation, as well as, activate the intrinsic coagulation pathway to accelerate blood coagulation. All the above results demonstrate that chitosan/diatom-biosilica aerogel has great potential to be a safe and rapid hemostatic material.

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Section: Methodsmentioning

confidence: 99%

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Sun

Zhang

et al. 2020

Adv Healthcare Materials

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“…Tranexamic acid-loaded starch microspheres may have potent hemostatic ability from the synergistic role of physical hemostasis by absorption of water to increase endogenous coagulation factors and platelets at the bleeding site and drug hemostasis by effective inhibition of fibrinolysis [180]. The drug-loaded material showed better hemostatic performance (shorter time to complete hemostasis and less bleeding volume) than a commercial hemostat made of microporous polysaccharide hemispheres in rabbit ear artery injury and liver injury, respectively.…”

Section: Flowable Hemostatic Agentsmentioning

confidence: 99%

Hemostatic agents for prehospital hemorrhage control: a narrative review

Peng

2020

Military Med Res

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Hemorrhage is the leading cause of preventable death in combat trauma and the secondary cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur before and in the first hour after hospital arrival. A literature search was performed through PubMed, Scopus, and Institute of Scientific Information databases for English language articles using terms relating to hemostatic agents, prehospital, battlefield or combat dressings, and prehospital hemostatic resuscitation, followed by cross-reference searching. Abstracts were screened to determine relevance and whether appropriate further review of the original articles was warranted. Based on these findings, this paper provides a review of a variety of hemostatic agents ranging from clinically approved products for human use to newly developed concepts with great potential for use in prehospital settings. These hemostatic agents can be administered either systemically or locally to stop bleeding through different mechanisms of action. Comparisons of current hemostatic products and further directions for prehospital hemorrhage control are also discussed.

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“…The hemostatic effect of TA has been demonstrated in numerous in vitro, preclinical and clinical studies. 18,[31][32][33] Sarda et al 32 reported on the development of hydroxyapatite with adsorbed TA and demonstrated local hemostatic activity with a lowered aPTT.…”

Section: Uv-vis Absorbance Spectra For Nanoclay Compositions Are Shown Inmentioning

confidence: 99%

“…More recently, Su et al 33 reported on TA loading of starch microspheres and concluded on their potent hemostatic activity with a reduction in aPTT. Our results are in line with these studies and demonstrate that undoped nanoclay microspheres are associated with a reduction in aPTT by half, while TA-doped compositions led to a reduction in aPTT by about two thirds compared to the plasma control alone.…”

Section: Uv-vis Absorbance Spectra For Nanoclay Compositions Are Shown Inmentioning

confidence: 99%

Tranexamic acid‐loaded hemostatic nanoclay microsphere frameworks

2021

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Fast acting topical hemostatic agents play a key role in hemorrhage control.Retarding fibrinolysis is also critical in improving coagulation, thereby expanding chances of survival. The purpose of the present work was to investigate the physical properties, loading capacity and hemostatic efficacy of newly developed nanoclay microsphere frameworks (NMFs) loaded with tranexamic acid (TA), as antifibrinolytic agent. Nanoclay compositions were prepared with increasing levels of TA. Results showed that TA was successfully incorporated into the nanoclay structure and released when solvated with ethanol. Both doped and undoped NMFs significantly decreased activated partial thromboplastin time and increased clot stiffness, which was attributed to significantly thinner fibrin fibers and a denser clot structure.

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Tranexamic acid-loaded starch hemostatic microspheres

Abstract: Efficacious hemostatics have significant potential for use in rapid exsanguinating hemorrhage control by emergency medical technicians or military medics nowadays.

Cited by 26 publications

References 34 publications

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Hemostatic agents for prehospital hemorrhage control: a narrative review

Tranexamic acid‐loaded hemostatic nanoclay microsphere frameworks

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