Trans-Compartmental Regulation of Tight Junction Barrier Function

Naser, Amna N.; Lü, Qun; Chen, Yanhua

doi:10.1080/21688370.2022.2133880

Cited by 11 publications

(7 citation statements)

References 70 publications

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“…TJs form the uppermost part of the blood–tissue barrier junction complex . By establishing a barrier similar to a semipermeable membrane between two cells, they can be modulated and can also act as an osmotic barrier .…”

Section: Discussionmentioning

confidence: 99%

“…TJs form the uppermost part of the blood−tissue barrier junction complex. 32 By establishing a barrier similar to a semipermeable membrane between two cells, they can be modulated and can also act as an osmotic barrier. 33 Functional TJs between adjacent Sertoli cells are a prerequisite for the normal functioning and structural integrity of BTB.…”

Section: ■ Discussionmentioning

confidence: 99%

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Deoxynivalenol Induces Blood–Testis Barrier Dysfunction through Disrupting p38 Signaling Pathway-Mediated Tight Junction Protein Expression and Distribution in Mice

Miao,

Wang,

Wang

et al. 2023

J. Agric. Food Chem.

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Deoxynivalenol (DON) is widely present in cereals and processed grains. It can disrupt the blood-testicular barrier (BTB), leading to sterility in males; however, the mechanism is unknown. In this study, 30 Kunming mice and TM4 cells were exposed to 0 or 4.8 mg/kg (28 d) and 0–2.4 μM (24 h) of DON, respectively. Histopathological findings showed that DON increased BTB permeability in mice, leading to tight junction (TJ) structural damage. Immunofluorescence results indicated that DON disrupted the localization of zonula occludens (ZO)-1. The results of protein and mRNA expression showed that the expression of ZO-1, occludin, and claudin-11 was reduced, and that the p38/GSK-3β/snail and p38/ATF-2/MLCK signaling pathways were activated in mouse testes and TM4 cells. Pretreatment with the p38 inhibitor SB203580 maintained TJ integrity in TM4 cells after exposure to DON. Thus, DON induced BTB dysfunction in mice by disrupting p38 pathway-mediated TJ expression and distribution.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Deoxynivalenol Induces Blood–Testis Barrier Dysfunction through Disrupting p38 Signaling Pathway-Mediated Tight Junction Protein Expression and Distribution in Mice

Miao,

Wang,

Wang

et al. 2023

J. Agric. Food Chem.

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“…TJs and AJs are intimately connected spatially and functionally and are collectively referred to as the apical junctional complex (AJC) ( Quiros and Nusrat, 2014 ; Naser et al, 2023 ). During epithelial differentiation and apico-basal polarization, TJ and AJ components initially colocalize but are eventually sorted into distinct apical TJs and basal AJs.…”

Section: The ‘Zonula Occludens’ Of Epithelial Cellsmentioning

confidence: 99%

A short guide to the tight junction

Citi,

Fromm,

Furuse

et al. 2024

Journal of Cell Science

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Tight junctions (TJs) are specialized regions of contact between cells of epithelial and endothelial tissues that form selective semipermeable paracellular barriers that establish and maintain body compartments with different fluid compositions. As such, the formation of TJs represents a critical step in metazoan evolution, allowing the formation of multicompartmental organisms and true, barrier-forming epithelia and endothelia. In the six decades that have passed since the first observations of TJs by transmission electron microscopy, much progress has been made in understanding the structure, function, molecular composition and regulation of TJs. The goal of this Perspective is to highlight the key concepts that have emerged through this research and the future challenges that lie ahead for the field.

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“…81 Located close to the apical ends of junction complex cell membrane, TJs immobilize the paracellular gap between neighboring intestinal epithelial cells. 82 TJs also block the paracellular passage of bacteria, poisons, and antigenic materials within the intestinal epithelium. 83 TJ assembly is extremely dynamic and alters frequently as a result of interactions with environmental irritants such as pathogenic symbiotic flora, poisons, and dietary residues.…”

Section: Intestinal Permeability Modulation Through Tightmentioning

confidence: 99%

“…Intercellular junction complexes, essential for controlling paracellular permeability and preserving barrier integrity, firmly bind intestinal epithelial cells at the paracellular interface and are composed of TJs, adherens junctions, gap junctions, and desmosomes . Located close to the apical ends of junction complex cell membrane, TJs immobilize the paracellular gap between neighboring intestinal epithelial cells . TJs also block the paracellular passage of bacteria, poisons, and antigenic materials within the intestinal epithelium .…”

Section: Intestinal Barrier Protection By Iapmentioning

confidence: 99%

Protective Properties of Intestinal Alkaline Phosphatase Supplementation on the Intestinal Barrier: Interactions and Effects

Gao,

Koko,

Hong

et al. 2023

J. Agric. Food Chem.

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The intestinal barrier is critical for maintaining intestinal homeostasis, and its dysfunction is associated with various diseases. Recent findings have revealed the multifunctional role of intestinal alkaline phosphatase (IAP) in diverse biological processes, including gut health maintenance and function. This review summarizes the protective effects of IAP on intestinal barrier integrity, encompassing the physical, chemical, microbial, and immune barriers. We discuss the results and insights from in vitro, animal model, and clinical studies as well as the available evidence regarding the impact of diet on IAP activity and expression. IAP can also be used as an indicator to assess intestinal-barrier-related diseases. Further research into the mechanisms of action and long-term health effects of IAP in maintaining overall intestinal health is essential for its future use as a dietary supplement or functional component in medical foods.

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Trans-Compartmental Regulation of Tight Junction Barrier Function

Cited by 11 publications

References 70 publications

Deoxynivalenol Induces Blood–Testis Barrier Dysfunction through Disrupting p38 Signaling Pathway-Mediated Tight Junction Protein Expression and Distribution in Mice

Deoxynivalenol Induces Blood–Testis Barrier Dysfunction through Disrupting p38 Signaling Pathway-Mediated Tight Junction Protein Expression and Distribution in Mice

A short guide to the tight junction

Protective Properties of Intestinal Alkaline Phosphatase Supplementation on the Intestinal Barrier: Interactions and Effects

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