trans-[Ru(NO)(NH3)4(py)](BF4)3·H2O encapsulated in PLGA microparticles for delivery of nitric oxide to B16-F10 cells: Cytotoxicity and phototoxicity

Biodegradable nanoparticles containing benzopsoralens: An attractive strategy for modifying vascular function in pathological skin disorders

“…50,57,58 The success of this process depends primarily on the retention of the hydrophobic active compound within the polymer-containing organic phase from which the matrix is formed after evaporation of the solvent. [58][59][60] The high value (74%) of the BP entrapment efficiency for the NP is consistent with the hydrophobic character of the compound. According to the literature, 61 the intravenous administration of particles with a diameter of several micrometers (larger than 6.0 lm) seems to be inefficient as a DDS because of its accumulation in lung capillaries and its difficult removal from the endothelial reticulum system.…”

Ruthenium(II)/4,6-dimethyl-2-mercaptopyrimidine complexes: Synthesis, characterization, X-ray structures and in vitro cytotoxicity activities on cancer cell lines

“…In these papers the authors suggested a possible role of NO in the observed cytotoxicity, considering the multifunctional involvement of this molecule in a number of physiological and pathological processes. Also, the trans-[Ru(NO)(NH 3 ) 4 (py)](BF 4 ) 3 is active against B16-F10 melanoma cells and, in the same way, the authors attributed cell death to the release of NO promoted by reduction in the cell environment [47]. In our case, for 1, also is possible the involvement of the NO in the observed cytotoxicity, but it is important to note that the chloro ligand can also be substituted, especially within cells where the concentration of chloride ions is low [48].…”

Immobilized ruthenium complexes and aspects of their reactivity

“…Some of the most widely used polymers for micro or nanoparticles preparation are PLA, PGA, and their co-polymer, PLGA [14,[87][88][89][90][91][92][93][94][95][96][97][98][99]. Two methods are commonly used for encapsulation of compounds in micro or nanoparticles, depending on the hydrophilic nature of the drug to be entrapped.…”

“…A wide range of materials can be used as matrices, including inorganic and organic polymers such as silica [1][2][3][4][5]7,20,[29][30][31], xerogels [21,[32][33][34], organic inorganic hybrid materials [34,35], silicone rubbers [36], polyurethane (PU) [16,36], poly(vinyl chloride) (PVC) [37], poly(vinyl alcohol) (PVA) [36,[38][39][40][41][42], poly(lactic-co-glycolic) acid (PLGA) [14], poly(methylmethacrylate) (PMA) [43] and dendrimers [6,44]. In addition, most of these materials can be made and/or modified, thereby resulting in different forms and shapes like powders, thin films, monoliths, nano or microparticles, and fibers [14,33,36,41,[45][46][47], which can serve as a platform for the immobilization of metal coordination compounds. Supramolecular chemistry and photochemistry devoted to energy conversion and devices constitute other important fields of application of materials containing incorporated metal complexes.…”