Trans-Sodium Crocetinate Restores Blood Pressure, Heart Rate, and Plasma Lactate after Hemorrhagic Shock

Abstract

It would appear that TSC is a promising initial treatment for hemorrhagic shock.

Pharmacological Interventions to Decompression Sickness in Rats: Comparison of Five Agents

“…kg-I). This dose is higher than the threshold dose of 0.1-0.2 mg' kg-1 and lower than the maximum tested without deleterious side effects (24).…”

“…Although TSC has not been extensively studied, crocetin has been examined in a number of 02-related experiments and was shown to increase O 2 diffusivity through plasma by 30% (23). Unlike fluoro carbons or hemoglobin, crocetin does not bind O 2 or in crease its solubility in blood plasma but increases O 2 consumption during hemorrhagic shock (24). TSC in creased mean arterial blood pressure immediately and reduced tachycardia in a rat model of hemorrhagic shock (24).…”

“…Some have suggested that when given during re suscitation from hemorrhage, crocetin restores cellular energy levels and reduces apoptosis (46). Interestingly, it has been suggested that TSC and O 2 therapy show similar results when used in a rat hemorrhage model (24). We tested a high and a low dose of TSC adminis tered predive as a prophylaxis against DCS in a rat model that favors neurological symptoms of DCS.…”

“…Unlike fluoro carbons or hemoglobin, crocetin does not bind O 2 or in crease its solubility in blood plasma but increases O 2 consumption during hemorrhagic shock (24). TSC in creased mean arterial blood pressure immediately and reduced tachycardia in a rat model of hemorrhagic shock (24). Some have suggested that when given during re suscitation from hemorrhage, crocetin restores cellular energy levels and reduces apoptosis (46).…”

Increasing Oxygen Consumption During Shock

“…From this point on, only TSC was used in our studies and most of the subsequent studies involved the effect of bolus injections of TSC on blood pressure, heart effect of a rate, blood acidosis and liver enzymes (3,4). First, the single bolus of TSC with no subsequent saline infusion being given was studied.…”