At present, collaborative industrial parks (CIPs) in the Yangtze River Delta Region (YRDR) have become an important spatial strategy for coordinating regional development. However, existing studies tend to focus on individualized micro-studies, ignoring the regional-scale production space reconstruction by the geographical expansion of CIPs. Based on this, this study takes the YRDR, where the development of CIPs is relatively mature, as an example and systematically analyzes their geographic expansion process and driving mechanism. The results found that CIPs in the YRDR have gone through three stages:the exploration period of CIP construction under the guidance of assistance policies; the blowout development period of CIPs under the demonstration effect; and the complete cluster formation period of CIPs. Regional central cities, such as Suzhou, Hangzhou, Nanjing, and underdeveloped cities, such as Tongling and Xuancheng, are core nodes, with Shanghai–Nantong; Shanghai–Anqing; Nanjing–Huainan; Wuxi–Xuzhou; Suzhou–Suqian; and Jiaxing–Lishui being important elements in the flow channel. The CIP network is basically formed. During this period, the degree of all nodes increased to 134, the network connection rate increased to 2.26, and the network complexity was more significant. Furthermore, CIPs are essentially a form of capital re-territorialization and space restoration organized and coordinated by the government (provincial government or central government). In the meantime, the market and the social environment, such as residents’ living standards, urban development foundation, urban transportation, and urban investment, also have an important impact on the geographic expansion of CIPs. In the regression results, the coefficients of popu, finance, labor, and passenger are significantly negative, but the coefficients of wage, gdp, freight, and govrd are significantly positive.