Transbronchial Biopsy and Usual Interstitial Pneumonia

Mukherjee, Suranjan; Spiteri, Monica A.

doi:10.1016/s0012-3692(15)37356-6

Cited by 7 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6,7 Transbronchial biopsy (TBB) via fiberoptic bronchoscopy (FBS) can provide diagnosis in some cases of ILD. [8][9][10][11] This technique, however, has been dismissed in clinical guidelines 1-3 because the frequently patchy nature of ILDs, small size of specimens obtained and poor preservation means that the diagnostic yield of TBB is at times less than 30%. 12,13 Recent studies have shown that, unlike conventional TBB, TBB using a cryoprobe (also known as cryobiopsy) is a viable technique for obtaining lung parenchyma samples with a higher diagnostic yield and relatively few complications.…”

Section: Introductionmentioning

confidence: 99%

Cryobiopsy in the Diagnosis of Diffuse Interstitial Lung Disease: Yield and Cost-Effectiveness Analysis

Hernández-González¹,

Lucena²,

Ramírez

et al. 2015

Archivos de Bronconeumología (English Edition)

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Cryobiopsy in the Diagnosis of Diffuse Interstitial Lung Disease: Yield and Cost-Effectiveness Analysis

Hernández-González¹,

Lucena²,

Ramírez

et al. 2015

Archivos de Bronconeumología (English Edition)

View full text Add to dashboard Cite

“…Although there is little data in the literature on the topic, some pathologists have suggested that 'collective wisdom be followed and TBB not be used to diagnose IPF/UIP', 28 while some clinicians have suggested that the use of TBB in diagnosing UIP is 'a step backward in disease management'. 29 These negative attitudes are fueled partially by unwillingness of pathologists to consider that a small biopsy specimen can yield useful information and partially on misconceptions of clinicians about the types of information that can be expected on TBB. For example, it is generally not understood that the patchwork pattern typical of UIP can be appreciated on TBB, or that honey-comb change can be recognized.…”

Section: Role Of Tbb In Diagnosing Uipmentioning

confidence: 99%

Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP

Katzenstein

2012

Modern Pathology

View full text Add to dashboard Cite

This review focuses on three selected topics of current interest that are related to chronic fibrosing lung disorders and are important for pathologists. First, the clinical and pathologic features of smoking-related interstitial fibrosis (SRIF) are highlighted. SRIF is a common finding in smokers that has striking histologic changes but only mild associated clinical manifestations. It is characterized by marked alveolar septal fibrosis composed of a distinct form of hyalinized collagen deposition. The process is present mainly in subpleural and centrilobular parenchyma and is associated with emphysema and respiratory bronchiolitis. Second, important aspects of the pathogenesis and treatment of usual interstitial pneumonia (UIP) are reviewed. The current theory proposes that UIP is caused by tiny foci of acute lung injury (manifest pathologically by fibroblast foci) that occur and recur in the interstitium over many years. Inflammation may be present as a secondary phenomenon, but is not the primary cause, and therefore anti-inflammatory agents have little effect. The recurrent injury leads to permanent fibrosis, through a process that is considered to represent a form of abnormal wound healing. Multiple therapies have been attempted that are aimed largely at interrupting the fibrosing process, but none have been successful. The cause of the injury is unknown, but a role for aspiration due to gastroesophageal reflux is a popular current theory, and there is some evidence that anti-reflux therapy may be beneficial. Genetic predisposition has been implicated in the etiology of familial cases, and there is evidence that telomere shortening may be important in sporadic cases. Third, the use of transbronchial biopsy (TBB) in diagnosing UIP is reviewed. TBB can provide a surprising amount of information and is especially useful in certain situations, such as elderly or very sick patients in whom surgical lung biopsy carries increased morbidity and mortality.

show abstract

“…Although there are very few relevant data in the literature, the ATS/ERS consensus statement on the idiopathic interstitial pneumonias states that TBB has no role in diagnosing these diseases other than to exclude alternate diagnoses such as infection, malignancy, or sarcoidosis [1]. Others state that "current wisdom" militates against the use of TBB in diagnosing UIP and that the use of TBB in this situation is a "step backward in disease management" [35,36]. The only article specifically addressing this subject, however, showed that diagnostic features of UIP are recognizable in nearly one third of TBBs and include various combinations of patchwork fibrosis, fibroblast foci, and/or honeycomb change [37].…”

Section: Use Of Transbronchial Lung Biopsy In Diagnosing Uipmentioning

confidence: 99%

Erratum to “Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases” [Hum Pathol 39 (2008) 1275-1294]

Katzenstein

Mukhopadhyay

2008

Human Pathology

View full text Add to dashboard Cite

Transbronchial Biopsy and Usual Interstitial Pneumonia

Cited by 7 publications

References 5 publications

Cryobiopsy in the Diagnosis of Diffuse Interstitial Lung Disease: Yield and Cost-Effectiveness Analysis

Cryobiopsy in the Diagnosis of Diffuse Interstitial Lung Disease: Yield and Cost-Effectiveness Analysis

Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP

Erratum to “Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases” [Hum Pathol 39 (2008) 1275-1294]

Contact Info

Product

Resources

About