Transbronchiale Lungenbiopsie bei Sarkoidose

Kopp, Claire B.; Perruchoud, A.; Heitz, Matthias; Dalquen, Peter; Herzog, H

doi:10.1007/bf02664332

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Previous studies describing iatrogenic PTX from bronchoscopy with TBB have reported a wide range of total biopsies performed [3,10–13,16,18,20–22,24,30–32,34]. A study by Hernandez Blasco and others assessed 169 immunocompetent outpatients with various pulmonary diagnoses who underwent bronchoscopy with TBB [18].…”

Section: Discussionmentioning

confidence: 99%

Pneumothorax After Transbronchial Biopsy in Pulmonary Fibrosis: Lessons from the Multicenter COMET Trial

Galli

Panetta

Gaeckle

et al. 2017

Lung

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Purpose Some patients with diffuse interstitial lung disease (ILD) undergo bronchoscopy with transbronchial biopsy (TBB) as part of their diagnostic evaluation. It is unclear what the incidence and risk factors for pneumothorax (PTX) following TBB are in this patient population. Methods Ninety-seven subjects with pulmonary fibrosis who underwent a research bronchoscopy with TBB as part of the multicenter Correlating Outcomes with Biochemical Markers to Estimate Time-progression in Idiopathic Pulmonary Fibrosis (COMET) trial were retrospectively reviewed. We compared subjects who developed a PTX during research bronchoscopy with TBB versus those who did not. Results Seven patients (7.2%) experienced a PTX during research bronchoscopy with TBB. Subjects who experienced PTX during TBB had significantly lower DLCO percent predicted (29 ± 8 versus 45 ± 15, P=0.006) and had lower resting room air saturation of peripheral oxygen (SPO2) on 6-minute walk testing (91±10 versus 95±3, P=0.02). No differences between groups were found with respect to age, gender, race, BMI, HRCT characteristics, or number of transbronchial biopsies performed. Conclusion The incidence of PTX following research bronchoscopy with TBB in patients with pulmonary fibrosis was found to be 7.2% in this study. Patients who developed a pneumothorax had greater impairments in gas exchange at baseline evidenced by a lower DLCO % predicted and a lower resting room air SPO2 when compared to subjects without PTX as a complication.

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Section: Discussionmentioning

confidence: 99%

Pneumothorax After Transbronchial Biopsy in Pulmonary Fibrosis: Lessons from the Multicenter COMET Trial

Galli

Panetta

Gaeckle

et al. 2017

Lung

View full text Add to dashboard Cite

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Sarcoidosis: clinical update

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2001

Eur Respir J

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Many advances have been made regarding sarcoidosis in the past 2 decades. As a result, sarcoidosis is now defined as a multisystem disorder with a heightened cellular immune response at sites of disease activity in patients with a predisposition for sarcoidosis and a presumed exposure to as yet unknown transmissible environmental agents.Recent International Consensus Statement recommendations regarding diagnosis and therapy have been published. The diagnosis of sarcoidosis is based on a compatible clinical and/or radiological picture, histological evidence of noncaseating granulomas and exclusion of other diseases capable of producing a similar histological or clinical picture.Therapy is based on corticosteroids, although there are indications of valuable alternatives. Except for life- and sight-threatening organ involvement, it should be carefully considered whether the patient might benefit from treatment. For asymptomatic pulmonary sarcoidosis, a watch and wait approach is appropriate; treatment should mainly be considered if symptoms develop or lung function deteriorates.

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Transbronchiale Lungenbiopsie bei Sarkoidose

Cited by 2 publications

References 14 publications

Pneumothorax After Transbronchial Biopsy in Pulmonary Fibrosis: Lessons from the Multicenter COMET Trial

Pneumothorax After Transbronchial Biopsy in Pulmonary Fibrosis: Lessons from the Multicenter COMET Trial

Sarcoidosis: clinical update

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