Transcatheter arterial embolization for treatment of hepatocellular carcinoma in a cat

Iwai, Satomi; Okano, Shozo; Chikazawa, Seishiro; Kakizaki, Takehiko; Sakonju, Iwao; Solomon, Jeffrey A.

doi:10.2460/javma.247.11.1299

Cited by 10 publications

(11 citation statements)

References 9 publications

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“…The cat's condition stabilized, and the tumor size was reduced, and surgical resection to prevent rebleeding was possible with good general condition. Arterial embolization procedures are now performed in veterinary practice for liver tumors that cannot be surgically removed, with the aim of palliative mass reduction (7)(8)(9). Arterial embolization combined with arterial infusion chemotherapy is commonly performed for the same purpose in our hospital.…”

Section: Discussionmentioning

confidence: 99%

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Case Report: Transcatheter Arterial Embolization for the Initial Management of Intra-Abdominal Hemorrhage From a Hepatic Tumor in a Cat

et al. 2021

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An 8-year-old Ragdoll cat was admitted to our hospital after its owner noticed sudden lethargy. Abdominal ultrasonography showed a large amount of blood in the abdominal cavity, and the cat was diagnosed as having hemorrhagic shock caused by the rupture of an intra-abdominal mass. Blood transfusion was performed on the 1st day of hospitalization. On the 2nd day, contrast-enhanced computed tomography (CT) was performed, and hemorrhage from a mass originating in the caudate lobe of the liver was noted. Transcatheter arterial embolization (TAE) was performed to stop the bleeding from the mass using Gelpart to embolize the feeding artery. The following day, fever and elevation of liver enzyme levels were observed, but these subsided within a few days. At discharge 5 days after TAE, no fluid was found in the peritoneal cavity, and no further intra-abdominal bleeding occurred. Sixty-six days after TAE, we were able to perform resection surgery with the cat in good condition. A partial response was observed on CT performed before surgery. Histopathology revealed cholangiocellular adenoma. The cat was doing well as of postoperative day 549. This case indicates that TAE may be effective for initial hemostasis and stabilization of conditions in animals with tumor-induced hemorrhage.

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Section: Discussionmentioning

confidence: 99%

“…A previous study reported complications of TAE in a cat owing to the sharp angle between the aorta and celiac artery in cats (9). They used a carotid artery approach to prevent this complication.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Transcatheter Arterial Embolization for the Initial Management of Intra-Abdominal Hemorrhage From a Hepatic Tumor in a Cat

et al. 2021

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“…TAE is an important component of the treatment of unresectable hepatocellular masses and is one of the standard therapies 6,8,14,15 . However, in veterinary medicine, studies on TAE consist mainly of case reports with few comprehensive studies, leading to an inability to assess the effectiveness of this intervention in veterinary patients 16–19 …”

Section: Introductionmentioning

confidence: 99%

Therapeutic response and prognostic factors of 14 dogs undergoing transcatheter arterial embolization for hepatocellular masses: A retrospective study

Kawamura

Itou

Kida

et al. 2023

Veterinary Internal Medicne

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Background Information regarding the therapeutic effect and outcome of transcatheter arterial embolization (TAE) for hepatic masses is limited in veterinary medicine. Hypothesis/Objectives To analyze the therapeutic response, outcome (overall survival), and their predictors in dogs that underwent TAE for primary hepatocellular masses. We hypothesized that larger pre‐TAE tumors would be associated with worse outcomes. Animals Fourteen client‐owned dogs. Methods Retrospective study. Medical records between 1 September 2016 and 30 April 2022 were reviewed to identify dogs treated with TAE for hepatic masses diagnosed as hepatocellular origin by cytological or histopathological examination. Computed tomography images were compared before and after TAE. The univariate Cox proportional hazards test was performed to assess the associations between variables and survival. Univariate linear regression analysis was performed to assess the associations between variables and the tumor reduction percentage: ([post‐TAE volume − pre‐TAE volume]/pre‐TAE volume) × 100. Results The median survival time was 419 days (95% confidence interval, 82‐474). History of intra‐abdominal hemorrhage (P = .03) and pre‐TAE tumor volume/body weight (P = .009) were significantly associated with overall survival. The mean reduction percentage was −51% ± 40%. Pre‐TAE tumor volume/body weight ratio (cm3/kg; P = .02, correlation coefficient = 0.704) was significantly correlated with the volume reduction percentage. Conclusions History of intra‐abdominal hemorrhage and large pre‐TAE tumor volume/body weight ratio could be predictive factors for adverse outcomes after TAE. Pre‐TAE tumor volume/body weight ratio could be a predictive factor for therapeutic effect.

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“…Notably, TAE improves pain and local control and prolongs survival rates in patients with unresectable HCC (Savastano et al 1993, Rand et al 2005. This method has recently been used in veterinary medicine (Weisse et al 2002, Cave et al 2003, Iwai et al 2015, although little practical information is available. Here, we report tumour responses, clinical reactions and adverse effects after selective embolisation of the tumour-supplying arteries using gelatine sponge particles (GSPs) in four dogs with HCC.…”

Section: Introductionmentioning

confidence: 99%

“…, Iwai et al . ), although little practical information is available. Here, we report tumour responses, clinical reactions and adverse effects after selective embolisation of the tumour‐supplying arteries using gelatine sponge particles (GSPs) in four dogs with HCC.…”

Section: Introductionmentioning

confidence: 99%

Transcatheter arterial embolisation in four dogs with hepatocellular carcinoma

Oishi

Tani

Taura

2018

J of Small Animal Practice

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Four dogs with hepatocellular carcinoma were treated by transcatheter arterial embolisation. In all dogs, the tumour‐supplying arteries were selectively embolised with gelatine sponge particles. Post‐embolisation tumour volumes decreased relative to pre‐embolisation volumes in all dogs. No adverse reactions were observed in three dogs after treatment but one dog showed pancreatitis. These results suggest that transcatheter arterial embolisation is a feasible treatment for dogs with hepatocellular carcinoma.

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Transcatheter arterial embolization for treatment of hepatocellular carcinoma in a cat

Abstract: Findings suggested that transcatheter arterial embolization may be suitable for treating hepatic tumors in cats, but alternative approaches are needed in cats, compared with dogs, owing to anatomic differences.

Cited by 10 publications

References 9 publications

Case Report: Transcatheter Arterial Embolization for the Initial Management of Intra-Abdominal Hemorrhage From a Hepatic Tumor in a Cat

Case Report: Transcatheter Arterial Embolization for the Initial Management of Intra-Abdominal Hemorrhage From a Hepatic Tumor in a Cat

Therapeutic response and prognostic factors of 14 dogs undergoing transcatheter arterial embolization for hepatocellular masses: A retrospective study

Transcatheter arterial embolisation in four dogs with hepatocellular carcinoma

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