Carotid angioplasty and stenting (CAS) has emerged as a feasible and safe alternative for the management of extracranial carotid occlusive disease. The appropriate clinical setting, indications and techniques to maximize the benefit of this new approach are in constant evolution. The success of CAS relies not only on technique, device selection and management of complications but, maybe more importantly, on patient selection, peri-operative medical management and pre-procedural imaging and planning. The purpose of this review is to describe the peri-procedural and technical steps that can optimize the results of CAS.