Transcorneal permeation of diclofenac as a function of temperature from film formulation in presence of triethanolamine and benzalkonium chloride

Mohapatra, Rajaram; Senapati, Sibananda; Sahoo, Chinmaya Keshari; Mallick, Subrata

doi:10.1016/j.colsurfb.2014.09.012

Cited by 16 publications

(9 citation statements)

References 47 publications

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“…The concurrent estimation of activation energy of permeation, partition, and diffusion coefficient as a component of temperature portrayed the thermodynamic approach of the drug permeation kinetic (Mallick, Mondal, & Sannigrahi, ). Here it has been found that the rising temperature lead to increase in partition, diffusion coefficients of permeation which implied the abatement in the activation energy (Mohapatra, Senapati, Sahoo, & Mallick, ).…”

Section: Discussionmentioning

confidence: 95%

Temperature‐dependent mucosal permeation kinetics of stigmasterol microspheres: In vivo mice model antioral candidiasis study

et al. 2019

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Evaluation of mucosal permeation of stigmasterol from the glutaraldehyde cross linked chitosan microspheres at increasing experimental temperatures was performed. The activation energy of permeation, partition, and diffusion were estimated to understand the permeation kinetic with respect to the temperature. The formulation depicting least activation energy possessed the increased permeation thresholds of drug at the site of application. The encapsulation efficacy and mucoadhesive strength were found to be directly proportional to the polymer‐emulsifier ratio. Decreased intensity in crystallography directed the molecular dispersion of microencapsulated drug. The depleted enthalpic phase transition in thermogram affirmed the stigmasterol encapsulation. The sphericity and the size of microspheres were determined by scanning electron photo micrograph. The in vivo quantification of oral Candida infection with different statistical approach and histopathological observation of infected tongue of mice on treatment with the stigmasterol encapsulated microspheres showed significant anti oral candidiasis activity by reduction of fungal colony count and recovery of papillae, reorganization of basal cell layer and newly formed papillae during 21–28 days of treatment.

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Section: Discussionmentioning

confidence: 95%

Temperature‐dependent mucosal permeation kinetics of stigmasterol microspheres: In vivo mice model antioral candidiasis study

et al. 2019

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“…Among all the formulations, the benzalkonium chloride-containing film along with HP-βcyclodextrin showed the highest result (BHTbC2: 95. film (BHTbC2 and BHTcC1 respectively) increased the release of drug on the mucosal surface because of its surfactant property and facilitated the better permeation via paracellular route compared to BHT [23]. Additionally, the cationic surfactants overcame the physiological and mucosal barrier for the increase of permeation and BZK exhibited better ability rather than CET [49]. Cyclodextrin exhibited increased transmucosal diffusion of omeprazole [21].…”

Section: Mucosal Permeation Studymentioning

confidence: 99%

Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery

Pattanaik¹,

Nandi²,

Sahoo³

et al. 2020

Rev. Chim.

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Budesonide, a glucocorticosteroid is generally used to treat chronic inflammation and asthma. Hepatic first-pass metabolism and poor solubility are the major causes of its limited oral bioavailability. Present work was undertaken for the preparation of hydrogel film formulation with cyclodextrin complexation of budesonide containing quaternary surfactant for possible enhancement of mucosal permeation. FTIR study confirmed drug-polymer hydrogen bonding. Almost complete amorphization of the drug was pronounced by SEM, DSC and XRD studies. The film containing benzalkonium and hydroxypropyl beta-cyclodextrin exhibited in vitro dissolution and mucosal permeation to the highest extent of 87.2 and 95.8 % respectively in contrast to the others. Film formed hydrogel in aqueous mucin and enhanced the mucosal tissue residence time due to the mucoadhesive nature of the polymer. Acute inflammation in the rabbit eye was controlled within 3 h by applying the film in the cul-de-sac. The presence of cyclodextrin and quaternary surfactant brought about significantly improved drug release and mucosal permeation compared to their absence in the HPMC film. Hydrogel formed in aqueous mucin enhanced the mucosal residence time and controlled acute inflammation in the rabbit eye within 3 h after topical application.

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“…As depicted in Figure 1, an intense peak was observed at 3317 cm -1 may be due to the amine group. 26 Peaks at 1715 and 1771 cm -1 may be formed due to stretch- ing of two carbonyl (C=O) groups in the drug structure. 27,28 The peak at 2969 cm -1 may be because of symmetric stretching of CH2 in both pure drug and formulations.…”

Section: Ftirmentioning

confidence: 99%

Influence of TiO2 on Mucosal Permeation of Aceclofenac: Analysis of Crystal Strain and Dislocation Density

Nandi¹,

Mishra²,

Sahoo³

et al. 2020

ACSi

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Titanium dioxide can adhere with human epithelial cells and have good tolerability. Present work has been undertaken to explore the influence of TiO2 on mucosal permeation of aceclofenac. Mucosal permeation of aeclofenac solution containing TiO2 has been carried out. In fourier transform infrared spectrosopy (FTIR), the intensity of the peaks has decreased along with the increase of TiO2 content in the formulation indicating a possible binding between drug and TiO2. Melting enthalpy has been decreased with the increased content of TiO2 in the solid. The status of crystal strain and dislocation density of TiO2 and aceclofenac in the solid state formulation has also been evaluated from Xray Diffraction data using Debye-Scherrer’s equation. Mucosal permeation of aceclofenac has shown sustained effect for more than 20 h in presence of titanium dioxide. Titanium dioxide could be used in designing formulation for sustaining mucosal aceclofenac delivery after performing risk assessment study.

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Transcorneal permeation of diclofenac as a function of temperature from film formulation in presence of triethanolamine and benzalkonium chloride

Cited by 16 publications

References 47 publications

Temperature‐dependent mucosal permeation kinetics of stigmasterol microspheres: In vivo mice model antioral candidiasis study

Temperature‐dependent mucosal permeation kinetics of stigmasterol microspheres: In vivo mice model antioral candidiasis study

Budesonide-Cyclodextrin in Hydrogel System: Impact of Quaternary Surfactant on in vitro-in vivo Assessment of Mucosal Drug Delivery

Influence of TiO2 on Mucosal Permeation of Aceclofenac: Analysis of Crystal Strain and Dislocation Density

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