Transcranial alternating current stimulation for chronic insomnia: A systematic review

Zheng, Wei; Lan, Xian-Jun; Qin, Zhen-Juan; Ungvári, Gábor S.; Xiang, Yu‐Tao

doi:10.1016/j.ajp.2023.103477

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…The findings from this meta-analysis suggest that tACS could be a viable non-pharmacological intervention for individuals with schizophrenia. Beyond its effectiveness in improving total and negative psychopathology of schizophrenia, tACS has been explored as a treatment for major depression (MDD) ( 45 ), chronic insomnia ( 46 ), attention deficit hyperactivity disorder (ADHD) ( 47 ), and pain disorders ( 48 ). For instance, a recent meta-analysis has determined that tACS effectively alleviates depression symptoms in individuals with MDD ( 45 ) while ensuring safety.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, as compared with tDCS, tACS seemed to cause fewer adverse effects ( 58 ). Therefore, tACS has been also proven as a safe intervention for patients suffering from MDD ( 45 ), chronic insomnia ( 46 ), and healthy participants ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

“…For instance, a recent meta-analysis has determined that tACS effectively alleviates depression symptoms in individuals with MDD (45) while ensuring safety. Furthermore, a systematic review of RCTs (n = 73) has demonstrated tACS as an effective and safe therapeutic approach for chronic insomnia (46). However, this systematic review found that tACS does not demonstrate efficacy in treating auditory hallucinations The treatment period was defined as spanning from initiating the first tACS treatment to the endpoint of the final tACS session.…”

Section: Discussionmentioning

confidence: 99%

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Transcranial alternating current stimulation for schizophrenia: a systematic review of randomized controlled studies

Wei,

Shi,

Lan

et al. 2024

Front. Psychiatry

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BackgroundIn randomized clinical trials (RCTs) investigating the application of transcranial alternating current stimulation (tACS) in schizophrenia, inconsistent results have been reported. The purpose of this exploratory systematic review of RCTs was to evaluate tACS as an adjunct treatment for patients with schizophrenia based on its therapeutic effects, tolerability, and safety.MethodsOur analysis included RCTs that evaluated adjunctive tACS’ effectiveness, tolerability, and safety in schizophrenia patients. Three independent authors extracted data and synthesized it using RevMan 5.3 software.ResultsThree RCTs involving 76 patients with schizophrenia were encompassed in the analysis, with 40 participants receiving active tACS and 36 receiving sham tACS. Our study revealed a significant superiority of active tACS over sham tACS in improving total psychopathology (standardized mean difference [SMD] = −0.61, 95% confidence interval [CI]: −1.12, −0.10; I2 = 16%, p = 0.02) and negative psychopathology (SMD = −0.65, 95% CI: −1.11, −0.18; I2 = 0%, p = 0.007) in schizophrenia. The two groups, however, showed no significant differences in positive psychopathology, general psychopathology, or auditory hallucinations (all p > 0.05). Two RCTs examined the neurocognitive effects of tACS, yielding varied findings. Both groups demonstrated similar rates of discontinuation due to any reason and adverse events (all p > 0.05).ConclusionAdjunctive tACS is promising as a viable approach for mitigating total and negative psychopathology in individuals diagnosed with schizophrenia. However, to gain a more comprehensive understanding of tACS’s therapeutic effects in schizophrenia, it is imperative to conduct extensive, meticulously planned, and well-documented RCTs.

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