Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models

Mendonça, Mariana E.; Santana, Marcus B.; Baptista, Abrahão Fontes; Datta, Abhishek; Bikson, Marom; Fregni, Felipe; Araujo, Cintia P.

doi:10.1016/j.jpain.2010.12.015

Cited by 149 publications

(165 citation statements)

References 33 publications

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“…We were careful to use this overly general term even though the PPC is clearly composed of multiple functional subsections -e.g., the superior parietal lobule, supramarginal gyrus, and angular gyrus. This problem of identifying the site of tDCS stimulation is currently being addressed through the application of cortical modeling (Datta et al, 2009aMendonca et al, 2011). These modeling data can provide considerable insight to the unintuitive spread of current through the cortex.…”

Section: Limitations and Open Questionsmentioning

confidence: 99%

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Jones¹,

Crane²,

Feenstra³

et al. 2012

PsycEXTRA Dataset

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The nature of parietal contributions to working memory (WM) remain poorly understood but of considerable interest. We previously reported that posterior parietal damage selectively impaired WM probed by recognition (Berryhill and Olson, 2008a). Recent studies provided support using a neuromodulatory technique, transcranial direct current stimulation (tDCS) applied to the right parietal cortex (P4). These studies confirmed parietal involvement in WM because parietal tDCS altered WM performance: anodal current tDCS improved performance in a change detection task, and cathodal current tDCS impaired performance on a sequential presentation task. Here, we tested whether these complementary results were due to different degrees of parietal involvement as a function of WM task demands, WM task difficulty, and/or participants' WM capacity. In Experiment 1, we applied cathodal and anodal tDCS to the right parietal cortex and tested participants on both previously used WM tasks. We observed an interaction between tDCS (anodal, cathodal), WM task difficulty, and participants' WM capacity. When the WM task was difficult, parietal stimulation (anodal or cathodal) improved WM performance selectively in participants with high WM capacity. In the low WM capacity group, parietal stimulation (anodal or cathodal) impaired WM performance. These nearly equal and opposite effects were only observed when the WM task was challenging, as in the change detection task. Experiment 2 probed the interplay of WM task difficulty and WM capacity in a parametric manner by varying set size in the WM change detection task. Here, the effect of parietal stimulation (anodal or cathodal) on the high WM capacity group followed a linear function as WM task difficulty increased with set size. The low WM capacity participants were largely unaffected by tDCS. These findings provide evidence that parietal involvement in WM performance depends on both WM capacity and WM task demands. We discuss these findings in terms of alternative WM strategies employed by low and high WM capacity individuals. We speculate that low WM capacity individuals do not recruit the posterior parietal lobe for WM tasks as efficiently as high WM capacity individuals. Consequently, tDCS provides greater benefit to individuals with high WM capacity.

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Section: Limitations and Open Questionsmentioning

confidence: 99%

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Jones¹,

Crane²,

Feenstra³

et al. 2012

PsycEXTRA Dataset

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“…At present, our best method for setting dosage is to use computational models to predict how the electrical energy will spread through the head from the point of delivery on the scalp. These models have so far been successful in understanding how to target perilesional areas of the stroke-affected brain , or in determining how best to alleviate chronic pain (Mendonca et al 2011); however, there are many gaps in our knowledge (Bestmann and Ward 2017). One particular problem is that many existing models use a 'standard' head model, drawn from an MRI scan of a healthy young adult.…”

Section: Key Unknowns and Future Directionsmentioning

confidence: 99%

Brain Stimulation for Cognitive Enhancement in the Older Person: State of the Art and Future Directions

Davis

2017

J Cogn Enhanc

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Advances in medicine and healthcare and better education about healthy living have led to a greater proportion of people living healthily into older age. As the global population ages, it will become necessary to address the societal implications of this demographic change. Successful treatment of physical illnesses means that people are more likely to experience cognitive decline, either naturally through the ageing process or through the onset of dementia and related disorders. This will shift the healthcare burden from physical to cognitive care. In addition, healthy, active people are likely to remain in work, meaning that cognitive performance in the healthy elderly will require monitoring and support. This review will consider the possible role of brain stimulation technology in preserving or enhancing cognitive health in the healthy ageing population, and will discuss the current state of scientific research and the gaps in our knowledge around stimulating the brain of the older person.

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“…The anodal electrode was placed between the ears, on the neck of the rat (parietal cortex), and the cathodal electrode was positioned at the midpoint between the lateral angles of both eyes (supraorbital area) 18,19,25 . This technique mimics tDCS protocols used in humans 26,27 , and it has been applied by our research group showing antinociceptive effects 18,19 . According to an earlier study 15 , a constant current intensity of 1 mA causes skin lesions, as current density is comparatively much higher than the traditional 1 mA tDCS using large pads in humans.…”

Section: Transcranial Direct Current Stimulation (Tdcs)mentioning

confidence: 99%

Evaluation of different procedure involved in the Transcranial Direct Current Stimulation (tDCS) technique experimental application

Adachi¹,

Oliveira²,

Vercelino³

et al. 2017

Clin. Biomed. Res.

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Introduction: The transcranial direct current stimulation (tDCS) is a non-invasive technique, which induces neuroplastic changes in the central nervous system of animals and humans. Furthermore, tDCS has been suggested as a therapeutic tool for pain management. The aim of this study was to standardize a non-invasive tDCS technique indexed by the nociceptive response of rats submitted to different conditions necessary to the tDCS application.

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Transcranial DC Stimulation in Fibromyalgia: Optimized Cortical Target Supported by High-Resolution Computational Models

Cited by 149 publications

References 33 publications

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Brain Stimulation for Cognitive Enhancement in the Older Person: State of the Art and Future Directions

Evaluation of different procedure involved in the Transcranial Direct Current Stimulation (tDCS) technique experimental application

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