Transcranial direct current stimulation over the primary motor cortex during fMRI

Antal, Andrea; Polanía, Rafael; Schmidt‐Samoa, Carsten; Dechent, Peter; Paulus, Walter

doi:10.1016/j.neuroimage.2010.11.085

Cited by 231 publications

(227 citation statements)

References 30 publications

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“…This may have prevented a similar correlation as reported by Holland et al (2011). In a second study, Antal et al (2011) applied atDCS over the primary motor cortex and subjects performed a self-paced finger tapping task. While no activity differences were found at the stimulation site, reduced activity was found in a tightly connected area (SMA) implicated with selfinitiated motor actions (Nachev et al, 2008).…”

Section: Discussionmentioning

confidence: 90%

“…Only few studies assessed the effects of tDCS on brain activity in the language (Holland et al, 2011) or motor domain (Antal et al, 2011;Polanía et al, 2011Polanía et al, , 2012Zheng et al, 2011). However, none of the previous studies addressed higher cognitive functions and, at the same time, provided comprehensive information on tDCS-induced task-related local activity changes and functional connectivity modulations.…”

Section: Discussionmentioning

confidence: 99%

“…This setting has been described previously and formal testing showed no electrode artifacts and only minor overall reductions of signal-to-noise ratio. Most importantly, no differences were found between areas closer or more distant to the electrode and when comparing active versus sham stimulations (Antal et al, 2011). The stimulating electrode was inserted in a 5 ϫ 7 cm 2 saline-soaked synthetic sponge, and centered over left Brodmann areas (BA) 44/45, as previous studies found significantly improved semantic fluency with this electrode montage (Iyer et al, 2005;Cattaneo et al, 2011).…”

Section: Methodsmentioning

confidence: 98%

“…In this study, atDCS-induced picture naming improvement was associated with reduced activity in left inferior frontal gyrus (IFG). In the motor domain, tDCS-induced changes of local brain activity and structurally connected remote brain areas have been described (Antal et al, 2011;Polanía et al, 2011;Zheng et al, 2011). However, a comprehensive assessment of tDCS-induced changes in task-related local activity and whole-brain functional connectivity has not been conducted for either motor or cognitive functions.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the left ventral IFG (vIFG) has specifically been implicated with semantic retrieval processes (Thompson-Schill et al, 1997). We thus expected behavioral improvement to be associ-ated with selectively decreased activity in the left vIFG, indicative of more efficient neural processing (Antal et al, 2011;Holland et al, 2011). In addition, task-independent resting-state fMRI investigated whole-brain functional connectivity.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation

Meinzer¹,

Antonenko²,

Lindenberg³

et al. 2012

J. Neurosci.

255

236

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Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo ("sham") controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation

Meinzer¹,

Antonenko²,

Lindenberg³

et al. 2012

J. Neurosci.

255

236

View full text Add to dashboard Cite

show abstract

Magnetic resonance imaging in neuromodulation

Downar

Davis

2015

Neuromodulation in Psychiatry

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Assessment of electric field distribution in anisotropic cortical and subcortical regions under the influence of tDCS

Shahid

Wen

Ahfock

2013

Bioelectromagnetics

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The focus of this study is to estimate the contribution of regional anisotropic conductivity on the spatial distribution of an induced electric field across gray matter (GM), white matter (WM), and subcortical regions under transcranial direct current stimulation (tDCS). The assessment was conducted using a passive high-resolution finite element head model with inhomogeneous and variable anisotropic conductivities derived from the diffusion tensor data. Electric field distribution was evaluated across different cortical as well as subcortical regions under four bicephalic electrode configurations. Results indicate that regional tissue heterogeneity and anisotropy cause the pattern of induced fields to vary in orientation and strength when compared to the isotropic scenario. Different electrode montages resulted in distinct distribution patterns with noticeable variations in field strengths. The effect of anisotropy is highly montage dependent and directional conductivity has a more profound effect in defining the strength of the induced field. The inclusion of anisotropy in the GM and subcortical regions has a significant effect on the strength and spatial distribution of the induced electric field. Under the (C3-Fp2) montage, the inclusion of GM and subcortical anisotropy increased the average percentage difference in the electric field strength of brain from 5% to 34% (WM anisotropy only). In terms of patterns distribution, the topographic errors increased from 9.9% to 40% (WM anisotropy only) across the brain.

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Transcranial direct current stimulation over the primary motor cortex during fMRI

Cited by 231 publications

References 30 publications

Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation

Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation

Magnetic resonance imaging in neuromodulation

Assessment of electric field distribution in anisotropic cortical and subcortical regions under the influence of tDCS

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