Transcranial direct current stimulation (tDCS) reverts behavioral alterations and brainstem BDNF level increase induced by neuropathic pain model: Long-lasting effect

Filho, Paulo Ricardo Marques; Vercelino, Rafael; Cioato, Stefânia Giotti; Medeiros, Liciane Fernandes; Oliveira, Carla de; Scarabelot, Vanessa Leal; Souza, Andressa de; Rozisky, Joanna Ripoll; Quevedo, Alexandre Silva de; Adachi, Lauren Naomi Spezia; Sanches, Paulo Roberto Stefani; Fregni, Felipe; Caumo, Wolnei; Torres, Iraci Lucena da Silva

doi:10.1016/j.pnpbp.2015.06.016

Cited by 43 publications

(28 citation statements)

References 96 publications

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“…In our study, the anode stimulation electrode was mounted contralateral or ipsilateral to the injured paw to measure the antinociceptive effect of tDCS, and our results demonstrated that both locations of A-tDCS led to significant decreases in pain. Our study supplements previous experiments in which the location of the electrode was not taken into consideration (Cioato et al, 2016; Filho et al, 2016). A possible mechanism of these results is supra-spinal antinociceptive activities via multiple parallel pathways (Pertovaara and Wei, 2003).…”

Section: Discussionsupporting

confidence: 89%

“…Numerous clinical studies have concluded that A-tDCS is an effective method for pain modulations, which is helpful at reducing both fibromyalgia and spinal cord injury related-pain (Fregni et al, 2006; Roizenblatt et al, 2007; Soler et al, 2010). There are also studies showing effects of A-tDCS in inflammatory and neuropathic pain in animals (Laste et al, 2012; Spezia Adachi et al, 2012; Cioato et al, 2016; Filho et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

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Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Han

Gao

Zhao

et al. 2017

Front. Behav. Neurosci.

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Background: Transcranial direct current stimulation (tDCS) is widely used to treat human nerve disorders and neuropathic pain by modulating the excitability of cortex. The effectiveness of tDCS is influenced by its stimulation parameters, but there have been no systematic studies to help guide the selection of different parameters.Objective: This study aims to assess the effects of tDCS of primary motor cortex (M1) on chronic neuropathic pain in rats and to test for the optimal parameter combinations for analgesia.Methods: Using the chronic neuropathic pain models of chronic constriction injury (CCI), we measured pain thresholds before and after anodal-tDCS (A-tDCS) using different parameter conditions, including stimulation intensity, stimulation time, intervention time and electrode located (ipsilateral or contralateral M1 of the ligated paw on male/female CCI models).Results: Following the application of A-tDCS over M1, we observed that the antinociceptive effects were depended on different parameters. First, we found that repetitive A-tDCS had a longer analgesic effect than single stimulus, and both ipsilateral-tDCS (ip-tDCS) and contralateral-tDCS (con-tDCS) produce a long-lasting analgesic effect on neuropathic pain. Second, the antinociceptive effects were intensity-dependent and time-dependent, high intensities worked better than low intensities and long stimulus durations worked better than short stimulus durations. Third, timing of the intervention after injury affected the stimulation outcome, early use of tDCS was an effective method to prevent the development of pain, and more frequent intervention induced more analgesia in CCI rats, finally, similar antinociceptive effects of con- and ip-tDCS were observed in both sexes of CCI rats.Conclusion: Optimized protocols of tDCS for treating antinociceptive effects were developed. These findings should be taken into consideration when using tDCS to produce analgesic effects in clinical applications.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Han

Gao

Zhao

et al. 2017

Front. Behav. Neurosci.

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“…The positive effects produced by the modulation of the glutamatergic system could eventually lead to the release of the brain-derived neurotrophic factor (BDNF) [ 55 ]. In fact, tDCS has shown to change the BDNF [ 56 ] promoting the BDNF-dependent synaptic plasticity [ 22 ].…”

Section: Understanding and Differentiating Tdcsmentioning

confidence: 99%

Transcranial direct current stimulation as a motor neurorehabilitation tool: an empirical review

Sánchez-Kuhn

Pérez-Fernández

Cánovas³

et al. 2017

BioMed Eng OnLine

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The present review collects the most relevant empirical evidence available in the literature until date regarding the effects of transcranial direct current stimulation (tDCS) on the human motor function. tDCS in a non-invasive neurostimulation technique that delivers a weak current through the brain scalp altering the cortical excitability on the target brain area. The electrical current modulates the resting membrane potential of a variety of neuronal population (as pyramidal and gabaergic neurons); raising or dropping the firing rate up or down, depending on the nature of the electrode and the applied intensity. These local changes additionally have shown long-lasting effects, evidenced by its promotion of the brain-derived neurotrophic factor. Due to its easy and safe application and its neuromodulatory effects, tDCS has attracted a big attention in the motor neurorehabilitation field among the last years. Therefore, the present manuscript updates the knowledge available about the main concept of tDCS, its practical use, safety considerations, and its underlying mechanisms of action. Moreover, we will focus on the empirical data obtained by studies regarding the application of tDCS on the motor function of healthy and clinical population, comprising motor deficiencies of a variety of pathologies as Parkinson’s disease, stroke, multiple sclerosis and cerebral palsy, among others. Finally, we will discuss the main current issues and future directions of tDCS as a motor neurorehabilitation tool.Electronic supplementary materialThe online version of this article (doi:10.1186/s12938-017-0361-8) contains supplementary material, which is available to authorized users.

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“…All possible measures were taken to minimize animal suffering and external sources of pain and discomfort. In addition, the minimum number of animals required to produce reliable scientific data was used based on previous studies of our research group that used similar methods (Spezia Adachi et al, ; Laste et al, ; Spezia Adachi et al, ; Schunck et al, ; Macedo et al, ; Filho et al, , Cioato et al, ).…”

Section: Methodsmentioning

confidence: 99%

StandardizedPassiflora incarnataL. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats

et al. 2017

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Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain-derived neurotrophic factor and interleukin-10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P. incarnata group) water for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days); (3: alcohol withdrawal group) alcohol for 19 days, 1 day interval and water (8 days); and (4: P. incarnata in alcohol withdrawal) alcohol for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days). The tail-flick and hot plate tests were used as nociceptive response measures. Confirming previous study of our group, it was showed that alcohol-treated groups presented an increase in the nociceptive thresholds after alcohol withdrawal, which was reverted by P. incarnata, measured by the hot plate test. Besides, alcohol treatment increased brain-derived neurotrophic factor and interleukin-10 levels in prefrontal cortex, which was not reverted by P. incarnata. Considering these results, the P. incarnata treatment might be a potential therapy in the alcohol withdrawal syndrome. Copyright © 2017 John Wiley & Sons, Ltd.

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Transcranial direct current stimulation (tDCS) reverts behavioral alterations and brainstem BDNF level increase induced by neuropathic pain model: Long-lasting effect

Cited by 43 publications

References 96 publications

Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Parameter Optimization Analysis of Prolonged Analgesia Effect of tDCS on Neuropathic Pain Rats

Transcranial direct current stimulation as a motor neurorehabilitation tool: an empirical review

StandardizedPassiflora incarnataL. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats

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