Transcranial Magnetic Stimulation in the Acute Treatment of Major Depressive Disorder

Abstract

PSYCHIATRIST.COM studies. 1-6 More recently, a large, multisite trial of TMS administered to patients with treatment-resistant depression demonstrated superiority for TMS over a sham condition in a randomized controlled trial. 7 A unique feature of that trial design allowed nonresponders (defined by prespecified criteria) who had received at least 4 weeks of double-blind treatment the opportunity to enroll in a second extension trial and receive 6 weeks of openlabel TMS. The enrollment of patients who had failed to respond during the blinded, randomized sham-controlled trial into an open-label extension provides additional insights into TMS treatment effectiveness. Specifically, for the subgroup of patients who had received the sham intervention during the previous double-blind study, this second, open-label study represents a partial crossover trial. Furthermore, for the patients who had not responded

A Multisite, Naturalistic, Observational Study of Transcranial Magnetic Stimulation for Patients With Pharmacoresistant Major Depressive Disorder

“…Janicak and colleagues 12 described outcome over 6 months in 99 patients who benefited from acute TMS treatment in a similar manner during either an earlier multisite randomized trial 17 or an open-label follow-up study. 15 Those patients also were tapered off TMS, transitioning to maintenance medication monotherapy over 3 weeks. During follow-up, the maintenance medication could not be switched or combined with other medications.…”

“…[4][5][6][7][8][9][10][11] Transcranial magnetic stimulation (TMS) is a safe, effective, and well-tolerated alternative to pharmacotherapy for MDD. [12][13][14][15][16][17][18] Cumulative data in the last decade support that benefit of acute TMS appears sustained over periods of weeks to months. 12,[18][19][20][21][22][23][24] Upon symptom reemergence, reintroduction of TMS often results in restoration of acute benefit.…”

Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)

“…Two recent positive metaanalyses suggest that the overall effect size with TMS in major depression is at least as good as that of standard pharmacotherapy (Lam et al, 2008;Schutter, 2008). Those clinical features that appear to be associated with greater response include younger age, lack of refractoriness to antidepressants, and no psychotic features (Avery et al, 2008).…”

“…Repeated analysis of neurocognitive functioning of TMS patients has not found any enduring negative effects from the procedure (Avery et al, 2008;Little et al, 2000). After a session, patients or subjects are able to drive home and return to work.…”

Eeg spectral characteristics in resistant depression patients on transcranial magnetic stimulation treatment

“…Основной мишенью для ее применения признаны депрессии, в том числе терапев-тически резистентные [3][4][5][6][7]. Методические принципы проведения ТМС до недавнего времени существенно не менялись [1,[8][9][10]. Не менялись и представления в от-ношении «когнитивной» безопасности ТМС, которая по влиянию на когнитивные функции существенно превос-ходит электросудорожную терапию [11,12].…”