Transcranial Slow Oscillation Stimulation During Sleep Enhances Memory Consolidation in Rats

Binder, Sonja; Berg, Karolin; Gasca, Fernando; Lafon, Belen; Parra, Lucas C.; Born, Jan; Marshall, Lisa

doi:10.1016/j.brs.2014.03.001

Cited by 69 publications

(52 citation statements)

References 61 publications

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“…During tDCS an extracellular field is generated in the brain affecting cortical and subcortical structures including deep brain structures such as the hippocampus [36], also affecting hippocampus-dependent tasks [37], [38]. Local stimulation can be recreated in vitro by applying uniform electric fields across hippocampal slices, which allow micro-recording from the dendritic and somatic layers independently (Figure 1A).…”

Section: Resultsmentioning

confidence: 99%

Direct Current Stimulation Alters Neuronal Input/Output Function

et al. 2017

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Background Direct current stimulation (DCS) affects both neuronal firing rate and synaptic efficacy. The neuronal input/output (I/O) function determines the likelihood that a neuron elicits an action potential in response to synaptic input of a given strength. Changes of the neuronal I/O function by DCS may underlie previous observations in animal models and human testing, yet have not been directly assessed. Objective Test if the neuronal input/output function is affected by DCS Methods Using rat hippocampal brain slices and computational modeling, we provide evidence for how DCS modulates the neuronal I/O function. Results We show for the first time that DCS modulates the likelihood of neuronal firing for a given and fixed synaptic input. Opposing polarization of soma and dendrite may have a synergistic effect for anodal stimulation, increasing the driving force of synaptic activity while simultaneously increasing spiking probability at the soma. For cathodal stimulation, however, the opposing effects tend to cancel. This results in an asymmetry in the strength of the effects of stimulation for opposite polarities. Conclusions Our results may explain the asymmetries observed in acute and long term effects of transcranial direct current stimulation.

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Section: Resultsmentioning

confidence: 99%

Direct Current Stimulation Alters Neuronal Input/Output Function

et al. 2017

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“…Finally, Marshall and collaborators have investigated the interaction of tDCS with hippocampo-neocortical rhythms and reported that a transcranial slow oscillation stimulation during sleep enhances memory consolidation in rats (anodes: bilaterally over the prefrontal cortex; return electrodes: over the cerebellum; sinusoidal constant current fluctuating between 0 and 5.6 μ A at a frequency of 1.5 Hz applied during non-rapid eyes movement sleep) (Binder et al, 2014a,b). …”

Section: Animal Models Of Tdcsmentioning

confidence: 99%

Transcranial direct current stimulation for memory enhancement: from clinical research to animal models

Bennabi

Pedron

Haffen

et al. 2014

Front. Syst. Neurosci.

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There is a growing demand for new brain-enhancing technologies to improve mental performance, both for patients with cognitive disorders and for healthy individuals. Transcranial direct current stimulation (tDCS) is a non-invasive, painless, and easy to use neuromodulatory technique that can improve performance on a variety of cognitive tasks in humans despite its exact mode of action remains unclear. We have conducted a mini-review of the literature to first briefly summarize the growing amount of data from clinical trials assessing the efficacy of tDCS, focusing exclusively on learning and memory performances in healthy human subjects and in patients with depression, schizophrenia, and other neurological disorders. We then discuss these findings in the context of the strikingly few studies resulting from animal research. Finally, we highlight future directions and limitations in this field and emphasize the need to develop translational studies to better understand how tDCS improves memory, a necessary condition before it can be used as a therapeutic tool.

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“…These studies used a slow-oscillating tDCS (sotDCS) paradigm as the induction of oscillations by transcranial stimulation is believed to interact with ongoing oscillatory cortical activities [29]. Animal and human studies have shown that sotDCS boosts slow oscillations during sleep and enhances memory [30,31]. Slow oscillatory activity exerts a grouping influence on faster EEG frequencies during the depolarizing up phase of these oscillations [32] and consequently entrains sleep spindles [33].…”

Section: Introductionmentioning

confidence: 99%