Transcranial Sonography in Neurodegenerative Diseases with Cognitive Decline

Favaretto, Silvia; Walter, Uwe; Baracchini, Claudio; Cagnin, Annachiara

doi:10.3233/jad-170382

Cited by 8 publications

(2 citation statements)

References 74 publications

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“…Early non-invasive examination tools such as transcranial sonography (Favaretto et al, 2018) have been improved, and functional neuroimaging techniques have been gradually applied in AD research (Dennis and Thompson, 2014; delEtoile and Adeli, 2017). The overarching goals of AD research are to determine when and how interventions can slow or stop cognitive decline in patients, and to identify early signs of decline and treatment response.…”

Section: Discussionmentioning

confidence: 99%

Publication Trends for Alzheimer's Disease Worldwide and in China: A 30-Year Bibliometric Analysis

Dong

Hong

et al. 2019

Front. Hum. Neurosci.

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Background: Alzheimer's disease, the most common form of dementia, has tremendous social and economic impact worldwide. This study aimed to analyze global trends in Alzheimer's disease research and to investigate China's contribution to this research. Methods: The quantity and influence of publications related to Alzheimer's disease in China and elsewhere were compared. The Web of Science (WOS) and PubMed databases were searched from 1988 to 2017 using the terms “Alzheimer's disease” or “Alzheimers disease.” Global Alzheimer's disease publications were classified and analyzed. Keywords, countries, and institutions publishing articles on Alzheimer's disease were analyzed, and citations of these articles were examined. Results: A total of 181,116 articles regarding Alzheimer's disease research were identified and analyzed. Neuroscience and neurology were the main research categories both globally and in China. Basic research dominated Alzheimer's publications, accounting for 30.93% of global publications and 95.31% of publications in China. A total of 8,935 journals published articles related to Alzheimer's disease. The journal Neurobiology of Aging published the most Alzheimer's disease-related articles, numbering 5,206 over the time period examined. The National Institutes of Health, the National Institute on Aging, and the Department of Health and Human Services jointly sponsored 11,809 articles, ranking first in the world. The National Natural Science Foundation of China funded the largest number of studies on Alzheimer's disease in China and recognized the importance of traditional Chinese medicine in Alzheimer's disease research. Conclusions: The present study provides data for global researchers to understand research perspectives and develop future research directions. In recent years, Chinese researchers have contributed significantly to global Alzheimer's research. Still, strengthening international cooperation could improve the quality and number of publications regarding Alzheimer's disease.

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Section: Discussionmentioning

confidence: 99%

Publication Trends for Alzheimer's Disease Worldwide and in China: A 30-Year Bibliometric Analysis

Dong

Hong

et al. 2019

Front. Hum. Neurosci.

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“…About 90% of patients with idiopathic Parkinson’s disease (PD) show increased echogenicity of substantia nigra (SN). 1 - 3 SN hyperechogenicity is also demonstrated in genetic forms of PD, including the ones with mutation in Parkin (PARK2), phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1 or PARK6), leucine-rich repeat kinase 2 (LRRK2 or PARK8), and glucocerebrosidase (GBA). 1 , 2 The degree of SN hyperechogenicity in genetic forms resembles those of sporadic ones.…”

Section: Introductionmentioning

confidence: 99%

Transcranial sonography in carriers of Gaucher disease

Omrani¹,

Ansari-Damavandi²,

Zamani³

et al. 2019

CJN

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Background: Glucocerebrosidase (GBA) mutation is the most common genetic risk factor in Parkinson’s disease (PD). Transcranial sonography (TCS) shows increased substantia nigra (SN) echogenicity in both idiopathic and genetic forms of PD. The goal of this study was to compare maximal area of SN hyperechogenicity (aSNmax) and diameter of third ventricle (DTV) between GBA mutation carriers and healthy controls. Methods: Twenty-six carriers of GBA mutation and twenty-six healthy controls underwent TCS. The aSNmax and the DTV were measured. Mini-mental status examination (MMSE) and demographic data of the subjects were recorded, too. Results: Mean aSNmax in GBA mutation carriers was significantly higher (0.31 ± 0.06 cm2) than controls (0.16 ± 0.04 cm2). Moreover, DTV was significantly higher in GBA mutation carriers group (3.98 ± 0.90 vs 3.29 ± 0.56 cm). Conclusion: Increased SN echogenicity and increased third ventricle diameter in GBA mutation carriers may be caused by alterations in iron metabolism with reference to their genetic status.

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Transcranial sonography imaging of brainstem raphe, substantia nigra and cerebral ventricles in patients with geriatric depression

Şenel

Ozel-Kizil

Sorgun

et al. 2020

Int J Geriat Psychiatry

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ObjectivesGeriatric depression is a special condition associated with a chronic course, treatment resistance and vascular processes. However, its neurobiology has not been fully elucidated. There is no study in geriatric depression evaluating deep brain structures with transcranial sonography (TCS) which is a low‐cost, non‐invasive and practical tool. The present study aimed to evaluate the changes in the echogenicity of brainstem raphe (BR), substantia nigra (SN) and ventricular diameters by TCS in association with cognitive dysfunctions in patients with geriatric depression.MethodsEchogenicity of BR and SN were assessed and transverse diameters of the third ventricle and frontal horns of the lateral ventricles were measured by TCS in 34 patients with DSM‐5 major depression and 31 healthy volunteers aged 60 and older. Cognitive functions were evaluated by using Mini Mental State Examination, Montreal Cognitive Assessment Tool, Clock Drawing Test and Subjective Memory Complaints Questionnaire.ResultsAlthough depressed patients had more subjective memory complaints than controls, they had similar cognitive performances. Reduced echogenicity (interrupted/invisible echogenic line) of BR was found to be significantly higher and the ventricular diameters were larger in the depressed group. There was no difference between the groups in terms of SN echogenicity. There was no correlation between ventricular diameters and depression severity or cognitive functions.ConclusionsResults of the present study are important in terms of pointing out neurobiological changes related to geriatric depression which are in parallel with the results of the studies in younger patients with depression. However, long‐term follow‐up studies are required for accurate differentiation of neurocognitive disorders.

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Transcranial Sonography in Neurodegenerative Diseases with Cognitive Decline

Cited by 8 publications

References 74 publications

Publication Trends for Alzheimer's Disease Worldwide and in China: A 30-Year Bibliometric Analysis

Publication Trends for Alzheimer's Disease Worldwide and in China: A 30-Year Bibliometric Analysis

Transcranial sonography in carriers of Gaucher disease

Transcranial sonography imaging of brainstem raphe, substantia nigra and cerebral ventricles in patients with geriatric depression

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