Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

“…Twenty-two studies included both men and women, one study [ 22 ] included only women, and one study [ 14 ] included only men. Within the eligible studies, eight [ 10 , 12 , 13 , 15 , 19 , 26 , 28 , 31 ] involved subjects with diabetes, three [ 8 , 21 , 27 ] involved subjects with MetS, twelve [ 8 , 10 , 12 – 16 , 20 , 24 , 25 , 27 , 28 ] involved nondiabetic healthy subjects, and eight [ 9 , 11 , 17 , 18 , 22 , 23 , 29 , 37 ] involved general (community-based/population-based) subjects. Overall, 52,785 subjects were enrolled in this meta-analysis.…”

Association between transcription factor 7-like 2 rs7903146 polymorphism and diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis

“…In the 1879 qualified cases, there were only 217 heterozygotes and 4 variant homozygotes. 35,37 No significant association between this variant and the phenotypes was found in East Asian ethnic groups (the T allele frequencies among East Asian groups are only 4.47% for Choi's study and 6.997% for Fu's study). Since the rarity of this particular SNP among East Asians might have reduced the statistical power, no significant difference was observed.…”

“…Other five studies had relatively small sizes (numbers of cases < 1000). 32,34,35,37,40 Table 2 lists the detailed allele and genotype distributions of each eligible study. The frequencies of variant T allele of rs7903146 in all participants were similar among the studies of Caucasian subjects, ranging from 33.5% to 44.9%.…”

“…Two studies on the East Asian participants reported a much lower frequency of T allele, which are 4.47% and 6.997%, respectively. 35,38 For the genotype comparisons in these studies, six studies provided the number of TT/TC/CC in cases and controls, while two studies focused on the comparison of TT + TC versus CC for the shortage with T allele. Table 3 shows the main results of this meta-analysis.…”

“…9 Among these genetic variants, rs7903146 on the chromosome 10q25 region has been the most frequently reported to be strongly associated with T2DM. 8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] It was also reported that TCF7L2 gene rs7903146 is linked with microvascular and macrovascular complications, such as coronary artery disease, 30,31 nephropathy, 20,32,33 retinopathy, 32,[34][35][36][37][38][39][40] and neuropathy. 37 However, some studies demonstrated that TCF7L2 rs7903146 is not consistently associated with DR, 32,34,35,38,39 while others suggested TCF7L2 genetic variability contributes to the development of DR. 36,37,40 Clarification of the actual role of TCF7L2 rs7903146 in DR process and identification of its function as a genetic risk marker will assist ophthalmologists to predict and debilitate diabetes complication.…”