Transcription factor EB controls both motogenic and mitogenic cell activities

Abstract

Transcription factor EB (TFEB) belongs to the microphthalmia family of bHLH-leucine zipper transcription factors and was first identified as an oncogene in a subset of renal cell carcinomas. In addition to exhibiting oncogenic activity, TFEB coordinates genetic programs connected with the cellular response to stress conditions, including roles in lysosome biogenesis, autophagy, and modulation of metabolism. As is the case for other transcription factors, the activities of TFEB are not limited to a specific cellular condition such as the response to stress, and recent findings indicate that TFEB has more widespread functions. Here, we review the emerging roles of TFEB in regulating cellular proliferation and motility. The well-established and emerging roles of TFEB suggest that this protein serves as a hub of signaling networks involved in many non-communicable diseases, such as cancer, ischaemic diseases and immune disorders, drug resistance mechanisms, and tissue generation.

Transcription factor EB as a key molecular factor in human health and its implication in diseases

“…Many human illnesses, including LSDs, neurodegenerative diseases, inflammatory diseases, and cancers, appear to be linked to dysregulated TFEB activity, indicating that TFEB modulation is a potential therapeutic target. 49 , 166 …”

“… 201 In addition, independent of its functions in the regulation of autophagic flow, TFEB may be essential for cell proliferation and motility. 166 According to a research, TFEB facilitates Wnt signaling to promote cancer growth. 94 …”

“…Many human illnesses, including LSDs, neurodegenerative diseases, inflammatory diseases, and cancers, appear to be linked to dysregulated TFEB activity, indicating that TFEB modulation is a potential therapeutic target. 49,166 TFEB in LSDs. LSDs are often brought on by mutations in the genes that produce the enzymes necessary for the breakdown of macromolecules and other functions of lysosomal homeostasis.…”

“…201 In addition, independent of its functions in the regulation of autophagic flow, TFEB may be essential for cell proliferation and motility. 166 According to a research, TFEB facilitates Wnt signaling to promote cancer growth. 94 According to reports, TFEB may help tumors develop and spread by increasing autophagy and endocytosis in prostate and pancreatic cancer cells to meet their metabolic demands.…”

Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy

“…This process is regulated by the phosphorylation of TFEB, which is mainly located in the cytoplasm, while the dephosphorylated form is generally found in the nucleus. TFEB is involved in the lysosome-to-nucleus signaling mechanism, transmitting information about the state of the lysosome to the nucleus to trigger transcriptional reactions, which further influence the process of crosstalk between lysosomes and the nucleus, controlling cellular clearance and energy metabolism [ 119 , 120 ].…”