Transcription factor LSF (TFCP2) inhibits melanoma growth

Goto, Yuji; Yajima, Ichiro; Kumasaka, Mayuko Y.; Ohgami, Nobutaka; Tanaka, Asami; Tsuzuki, Toyonori; Inoue, Yoshio; Fukushima, Satoshi; Ihn, Hironobu; Kyoya, Mikiko; Ohashi, Hiroyuki; Kawakami, Tamihiro; Bennett, Dorothy C.; Kato, Masashi

doi:10.18632/oncotarget.6230

Cited by 26 publications

(21 citation statements)

References 22 publications

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“…Moreover, several studies have shown that CDKN1A plays a crucial role in cancer cells by modulating cell cycle arrest, cell growth, proliferation, migration inhibition, and apoptosis induction (Abbas and Dutta, 2009). Goto et al (2016) found that TFCP2 plays a predominant role in the regulation of CDKN1A, thereby inhibiting cell growth. In our study, CDKN1A expression was significantly upregulated when miR-660-5p was inhibited.…”

Section: Discussionmentioning

confidence: 99%

“…TFCP2 functions as an oncogene in hepatocellular carcinomas, and an increased expression level of TFCP2 promotes malignant progression (Saxena et al, 2010). Goto et al (2016) found an opposite role of TFCP2 in melanoma, whereby increased TFCP2 expression levels suppressed both the anchorage-dependent and -independent growth of melanoma cells. However, the functions and the specific molecular mechanism of action of TFCP2 in breast cancer remain obscure.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer

Shen

Ruan

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered that miR-660-5p was upregulated in the breast cancer cell lines MCF7 and MDA-MB-231 compared with that in the normal control cell line CCD-1095Sk. We then inhibited the expression of miR-660-5p to investigate its biological function in cancer development, progression, and metastasis. We determined the changes in the levels of expression of transcription factor CP2 (TFCP2) and CDKN1A to further clarify the specific mechanism involved. The results showed that downregulation of miR-660-5p significantly suppressed the proliferation, migration, and invasion of MCF7 breast cancer cell. Moreover, inhibition of miR- 660-5p promoted cell cycle G1 arrest and reduced apoptosis in breast cancer cells. The specific mechanism studies confirmed that TFCP2 was a direct downstream target of miR-660-5p. Aberrant expression of miR-660-5p repressed TFCP2 expression, whereas inhibition of miR-660-5p decreased TFCP2 protein expression, which is a vital factor in the downstream signaling pathway. In conclusion, miR-660-5p can regulate the proliferation, migration, and invasion of human breast cancer cells, and is a novel potential therapeutic target for the clinical treatment of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer

Shen

Ruan

et al. 2017

Genet. Mol. Res.

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“…cluster that has been shown to be involved in many cellular functions, including cell proliferation, migration and differentiation. [13][14][15] The miR-23b/24/27b cluster can act as a tumor suppressor in prostate, ovarian, bladder and colorectal cancers, 3,[16][17][18] whereas it promotes tumor progression in breast cancer. 19 However, the role of miR-23b in normal tissue, including epidermis, remains to be clarified.…”

Section: Mir-23b Belongs To the Mir-23b/24/27bmentioning

confidence: 99%

MicroRNA‐23b‐3p regulates human keratinocyte differentiation through repression of TGIF1 and activation of the TGF‐ß–SMAD2 signalling pathway

Barbollat-Boutrand

Joly‐Tonetti

Santos³

et al. 2016

Experimental Dermatology

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MicroRNAs (miRNAs) are a class of short non-coding RNAs capable of repressing gene expression at the post-transcriptional level. miRNAs participate in the control of numerous cellular mechanisms, including skin homeostasis and epidermal differentiation. However, few miRNAs involved in these processes have been identified so far in human skin, and the gene networks they control remain largely unknown. Here, we focused on miR-23b-3p, a miRNA that is expressed during the late step of human keratinocyte differentiation. We report that miR-23b-3p silencing modulates epidermal differentiation in human skin reconstructs. The SMAD transcriptional corepressor TGIF1 was identified on bioinformatic analysis as a potential target of miR-23b-3p. Expression analysis and reporter gene assays confirmed direct regulation of TGIF1 expression by miR-23b-3p. Finally, we showed that miR-23-3p was able to activate TGF-ß signalling in human keratinocytes by increasing SMAD2 phosphorylation through TGIF1 repression. Taken together, these data identify miR-23b-3p as a new regulator of human epidermal differentiation in line with TGF-ß signalling.

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“…However, the expression level of TFCP2 is decreased in melanoma, and up‐regulated TFCP2 suppresses melanoma cell growth and increases the percentage of G1 phase cells (Goto et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…Inhibition of TFCP2 abrogates HCC cell growth and metastasis in vivo and in vitro (Santhekadur et al 2012;Rajasekaran et al 2015). However, the expression level of TFCP2 is decreased in melanoma, and up-regulated TFCP2 suppresses melanoma cell growth and increases the percentage of G1 phase cells (Goto et al 2016).…”

Section: Discussionmentioning

confidence: 99%

The aberrantly expressed long non‐coding RNA in the substantia nigra and corpus striatum of Nrf2‐knockout mice

Liu

Kang

et al. 2017

Journal of Neurochemistry

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Nuclear factor erythroid 2 like 2 (Nrf2) functions as a neuroprotective agent in Parkinson's disease (PD). This study aimed to investigate the key long non-coding RNAs (lncRNAs) correlated with Nrf2, which might provide valuable information for the exploration of pathogenesis of PD. The lncRNA and mRNA expression profiling of substantia nigra and corpus striatum of Nrf2 (-/-) mice model was obtained from microarray analysis. The animal experiments conducted for this study were approved by the ethics committee of Hebei Medical University. Bioinformatics analyses were conducted, including differentially expressed lncRNAs/mRNA (differentially expressed lncRNA, DEL/differentially expressed mRNA, DEM) identification, DEL-DEM coexpression network construction, and biological functions prediction. Quantitative real-time polymerase chain reaction (qRT-PCR) was subjected to validate abnormally expressed DELs and DEMs in the substantia nigra and corpus striatum of Nrf2 (-/-) mice model. A total of 48 DELs (37 down-regulated and 11 up-regulated) were identified both in Nrf2 (-/-) substantia nigra and corpus striatum; 96 DEMs and 643 DEMs were identified in the substantia nigra and corpus striatum, respectively. DEL-DEM coexpressed network was constructed. LncRNA AK076880, AK036620, and AK020330 had high connectivity with DEMs both in the substantia nigra and corpus striatum. These DEMs were significantly enriched in signaling pathways such as the calcium signaling pathway, Huntington's disease, Alzheimer's disease, mitogen-activated protein kinase (MAPK) signaling pathway, and the Wnt signaling pathway. Generally, qRT-PCR validation results of selected DEMs and DELs were consistent with microarray data. The dysregulated DELs and DEMs in the substantia nigra and corpus striatum of Nrf2 (-/-) mice were identified. Our results might provide useful information for further exploring the pathogenesis mechanism of PD.

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Transcription factor LSF (TFCP2) inhibits melanoma growth

Abstract: ABSTRACT

Cited by 26 publications

References 22 publications

Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer

Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer

MicroRNA‐23b‐3p regulates human keratinocyte differentiation through repression of TGIF1 and activation of the TGF‐ß–SMAD2 signalling pathway

The aberrantly expressed long non‐coding RNA in the substantia nigra and corpus striatum of Nrf2‐knockout mice

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