Transcriptional changes in Manila clam (Ruditapes philippinarum) in response to Brown Ring Disease

Allam, Bassem; Espinosa, Emmanuelle Pales; Tanguy, Arnaud; Jeffroy, F.; Bris, Cédric Le; Paillard, Christine

doi:10.1016/j.fsi.2014.05.022

Cited by 69 publications

(48 citation statements)

References 79 publications

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“…Members of the lysozyme families (N-acetylmuramide glycanhydrolase) have been characterized in mucosal tissues and secretions of several bivalve species, as described in mussels [181], clams [182], scallops [183] and oysters [184], displaying a broad spectrum of antimicrobial activity and playing a dual role both in nutrition and immunity [185]. Moreover, the presence of plasma proteases’ activity was previously described in marine bivalve mollusks as a microbicidal mechanism [186,187], and such evidence has accounted for the isolation and characterization of genes encoding proteases, such as cathepsins [188]. …”

Section: Defense Mechanisms In Marine Bivalve Mollusksmentioning

confidence: 99%

Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense

et al. 2017

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A variety of bivalve mollusks (phylum Mollusca, class Bivalvia) constitute a prominent commodity in fisheries and aquacultures, but are also crucial in order to preserve our ecosystem’s complexity and function. Bivalve mollusks, such as clams, mussels, oysters and scallops, are relevant bred species, and their global farming maintains a high incremental annual growth rate, representing a considerable proportion of the overall fishery activities. Bivalve mollusks are filter feeders; therefore by filtering a great quantity of water, they may bioaccumulate in their tissues a high number of microorganisms that can be considered infectious for humans and higher vertebrates. Moreover, since some pathogens are also able to infect bivalve mollusks, they are a threat for the entire mollusk farming industry. In consideration of the leading role in aquaculture and the growing financial importance of bivalve farming, much interest has been recently devoted to investigate the pathogenesis of infectious diseases of these mollusks in order to be prepared for public health emergencies and to avoid dreadful income losses. Several bacterial and viral pathogens will be described herein. Despite the minor complexity of the organization of the immune system of bivalves, compared to mammalian immune systems, a precise description of the different mechanisms that induce its activation and functioning is still missing. In the present review, a substantial consideration will be devoted in outlining the immune responses of bivalves and their repertoire of immune cells. Finally, we will focus on the description of antimicrobial peptides that have been identified and characterized in bivalve mollusks. Their structural and antimicrobial features are also of great interest for the biotechnology sector as antimicrobial templates to combat the increasing antibiotic-resistance of different pathogenic bacteria that plague the human population all over the world.

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Section: Defense Mechanisms In Marine Bivalve Mollusksmentioning

confidence: 99%

Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense

et al. 2017

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“…Our findings highlight two major processes that may be contributing to variable immunity in corals: apoptosis and autophagy. Apoptosis has complex and multi-faceted roles in innate immunity, serving as both a crucial aspect of immediate immune response [20][21][22] and a last-resort (i.e. cell death) response [23,76] depending on the circumstances and stage of infection.…”

Section: (A) Apoptosis Is Activated In Disease-susceptible Speciesmentioning

confidence: 99%

“…Apoptosis is an essential regulatory pathway that results in controlled cell death [13][14][15][16][17][18][19]. Additionally, apoptosis is an important component of organismal responses to stress [15,18] and pathogenic infection [20][21][22]. Initially, controlled apoptosis of infected cells may serve to prevent further infection of an organism [20 -22].…”

Section: Introductionmentioning

confidence: 99%

Life or death: disease-tolerant coral species activate autophagy following immune challenge

Fuess

Weil

et al. 2017

Proc. R. Soc. B.

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Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclusive, dictating whether a cell adapts or dies. In order to examine differences in cellular response to stress, we compared the immune response of four coral species with a range of disease susceptibility. Using RNA-seq and novel pathway analysis, we were able to identify differences in response to immune stimulation between these species. Disease-susceptible species activated pathways associated with apoptosis. By contrast, disease-tolerant species and activated autophagic pathways. Moderately susceptible species activated a mixture of these pathways. These findings were corroborated by apoptotic caspase protein assays, which indicated increased caspase activity following immune stimulation in susceptible species. Our results indicate that in response to immune stress, disease-tolerant species activate cellular adaptive mechanisms such as autophagy, while susceptible species turn on cell death pathways. Differences in these cellular maintenance pathways may therefore influence the organismal stress response. Further study of these pathways will increase understanding of differential stress response and species survival in the face of changing environments.

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“…Microarrays have also been applied to bivalves for different purposes [26][27][28]. To our knowledge, a toxicogenomics study in the gill and the digestive gland [20] and a recent study of the response to brown ring disease, [29] are the only works to date to use an oligo-microarray in R. philippinarum.…”

Section: Introductionmentioning

confidence: 99%

Gene expression profile analysis of Manila clam (Ruditapes philippinarum) hemocytes after a Vibrio alginolyticus challenge using an immune-enriched oligo-microarray

Moreira

Milan

Balseiro

et al. 2013

Fish & Shellfish Immunology

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Transcriptional changes in Manila clam (Ruditapes philippinarum) in response to Brown Ring Disease

Cited by 69 publications

References 79 publications

Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense

Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense

Life or death: disease-tolerant coral species activate autophagy following immune challenge

Gene expression profile analysis of Manila clam (Ruditapes philippinarum) hemocytes after a Vibrio alginolyticus challenge using an immune-enriched oligo-microarray

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