Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

Mitchell, Pamela J.; Tjian, Robert

doi:10.1126/science.2667136

Cited by 3,113 publications

(1,735 citation statements)

References 150 publications

Supporting

Mentioning

1,688

Contrasting

Unclassified

Order By: Relevance

“…It leads to the increase in protein sizes and may promote the acquisition of new functions (Mortlock et al, 2000). The high proline, alanine, and glycine content is associated with transcription activation domains in transcription factors (Mitchell and Tjian, 1989;McDowall et al, 1999). On the other hand, alanine repeats or alanine-rich regions may possess repressive activity (Briata et al, 1995;Hanna-Rose and Hansen, 1996;Maurer et al, 2003).…”

Section: Features Of Chicken and Mammalian Foxl2mentioning

confidence: 99%

Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development

Govoroun

Pannetier

Pailhoux

et al. 2004

Developmental Dynamics

192

119

View full text Add to dashboard Cite

Mutations in the forkhead transcription factor gene FOXL2 are involved in ovarian failure, which occurs in human BPES syndrome. This syndrome presents a sexually dimorphic expression, specific to the ovary in several vertebrates. We cloned the open reading frame of chicken FOXL2 (cFoxL2) and studied cFoxL2 expression in developing gonads and during adulthood to examine the role of FOXL2 in ovarian differentiation and function in birds. The spatial and temporal dynamics of cFoxL2 and aromatase expression were analyzed in parallel by using real-time quantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry in attempt to investigate the possible role of cFoxL2 in the regulation of aromatase. The expression patterns of cFoxL2 and aromatase transcripts were highly correlated during the sex-differentiation period (4.7-12.7 days of incubation). Aromatase and cFoxL2 proteins were colocalized in the medullar part of female gonads on embryonic day 14. Fourteen days after hatching, cFoxL2 protein was mainly detected in granulosa cells of developing follicles. In adult ovary follicular envelopes, apart from granulosa cells, cFoxL2 transcript and protein were detected at lower levels in theca cells where aromatase was present. A high level of cFoxL2 transcription was also observed in maturing and ovulated oocytes. Our results confirm that FoxL2 is an early regulator of ovarian development in birds and may be involved in aromatase transcription regulation. Developmental Dynamics 231:859 -870, 2004.

show abstract

Section: Features Of Chicken and Mammalian Foxl2mentioning

confidence: 99%

Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development

Govoroun

Pannetier

Pailhoux

et al. 2004

Developmental Dynamics

192

119

View full text Add to dashboard Cite

show abstract

“…Several types of activation domain have been described which are rich in either acidic amino acids, proline residues or glutamine residues (for review see Mitchell & Tjian 1989).…”

Section: Activationmentioning

confidence: 99%

Transcription factors: An overview

Latchman

1997

The International Journal of Biochemistry & Cell Biology

691

426

View full text Add to dashboard Cite

“…No consensus TATA or CAAT boxes were detected upstream of the transcription-start site. The region between positions k310 and j1 is 80% GjC rich and contains five GC boxes known as potential binding sites for the nuclear transcription factor Sp1 [50] at positions k16, k26, k38, k42 and k119. Two of them are embedded at positions k38 and k42.…”

Section: Analysis Of the 5h-flanking Region Of The Acc Genementioning

confidence: 99%

Cloning and characterization of the 5′ end and promoter region of the chicken acetyl-CoA carboxylase gene

Mounier

Fur

Powell

et al. 1996

Biochemical Journal

View full text Add to dashboard Cite

Acetyl-CoA carboxylase is a rate-limiting enzyme in the biogenesis of long-chain fatty acids. In the present study, the 5h end and flanking region of the acetyl-CoA carboxylase (ACC) gene was analysed in the chicken. A genomic clone was isolated containing the first three exons, the third one containing the ATG codon. Using nuclease-mapping experiments and primerextension analyses, the transcription-initiation site was located 153 nucleotides upstream of the ATG codon. In contrast with rat ACC gene expression, reverse transcriptase PCR analysis performed on chicken liver mRNA did not reveal alternative splicing in the 5h-untranslated region of these messengers. The promoter

show abstract

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

Cited by 3,113 publications

References 150 publications

Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development

Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development

Transcription factors: An overview

Cloning and characterization of the 5′ end and promoter region of the chicken acetyl-CoA carboxylase gene

Contact Info

Product

Resources

About