Transcriptional Regulation of Articular Chondrocyte Function and Its Implication in Osteoarthritis

Wang, Jinxi; Kramer, William C; Schroeppel, John Paul

doi:10.5772/27632

Cited by 1 publication

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References 128 publications

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“…Shape changing of decreasing of long diameters of chondrocytes at this study as a sign which chondrocytes entering a hypertrophic phase from proliferation phase. This condition will give no good impact to cartilage health in the future, because hypertrophic chondrocytes produce more catabolic factor such as: IL-1ß (Interleukin 1 beta), FGF-2 (Fibroblast Growth Factor 2) which increasing of cartilage matrix degradation ( 11 ). Changing of chondrocytes distance as a sign that hyperglycemia of animal model at present study showed the negative impact to the chondrocytes population at the superficial layer of cartilage layer.…”

Section: Discussionmentioning

confidence: 99%

Chondrocyte Intracellular Matrix Strain Fields of Articular Cartilage Surface in Hyperglycemia Model of Rat: Cellular Morphological Study

et al. 2018

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Introduction:Chondrocyte is one cell in articular cartilage was products many proteins, molecules, and other factors. The external influence of cartilage, such as: hyperglycemia was entering joint capsule and impact to the chondrocytes and the cartilage. Hyperglycemia caused modification of heparan sulfate proteoglycan 2 (perlecan) proteins through glycation process.Aim:The aim of this study was to analyze morphological changing of chondrocytes pericellular matrix by the influence of hyperglycemia.Material and Methods:Eighteen adult male rats were divided into six groups: control, rat treated with sugar intake was 0.5 mg/kg, 0.75 mg/ kg, 1mg/kg, 1.5 g/kg and 2 mg/kg of body weight. The animal model was dislocated and left knee was taken to observe changing of chondrocytes pericellular matrix strain fields by Scanning Electron Microscope (SEM) from perpendicular to femoral condylus cartilage.Results:Changing of chondrocytes intracellular matrix strain fields as changing of cell diameters and cell distances at group control and group I to group V, which cell diameters was lower level and cell distances was the highest level at over diet 2. This changing of intracellular matrix strain fields was corresponding to changing chondrocytes morphology in hyperglycemia condition, due to hypertrophic stage as adaptive responses. This research as based on next research for accomplish of hyperglycemia influence to morphology articular cartilage changing to prevent degeneration of cartilage towards osteoarthritis.Conclusions:Present study concludes that hyperglycemia influence to chondrocyte intracellular matrix strain fields changing.

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Section: Discussionmentioning

confidence: 99%