2016
DOI: 10.3892/ijo.2016.3643
|View full text |Cite
|
Sign up to set email alerts
|

Transcriptional regulation of E-cadherin by small activating RNA: A new double-stranded RNA

Abstract: Recent studies have reported that chemically synthesized small activating RNA (saRNA) targeting the promoter regions of a gene can activate its expression in different cell lines. This technique can be a powerful therapeutic method for diseases caused by complete inactivation or reduced expression of specific genes. E-cadherin is a typical tumor suppressor gene. Loss of E-cadherin mediates the transition from benign lesions to invasive, metastatic cancer. In this study, several 21-nt small double-stranded RNAs… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(3 citation statements)
references
References 35 publications
0
3
0
Order By: Relevance
“…[7][8][9] Meanwhile, similar findings on RNAa for more genes were reported. [10][11][12][13] With the in-depth study of RNAa, a consensus has been reached that RNAa is a general mechanism for gene regulation.…”
Section: Introductionmentioning
confidence: 99%
“…[7][8][9] Meanwhile, similar findings on RNAa for more genes were reported. [10][11][12][13] With the in-depth study of RNAa, a consensus has been reached that RNAa is a general mechanism for gene regulation.…”
Section: Introductionmentioning
confidence: 99%
“…CDH1 is a TSG that has gained attention for its potential to be upregulated using saRNAs and has been investigated in this context across many cancer types. 2 , 23 , 24 , 25 , 26 , 27 CDH1 encodes the transmembrane glycoprotein E-cadherin, which is involved in maintaining epithelial cell morphology via adherens junction connections. 67 Furthermore, E-cadherin is anchored to the cell’s cytoskeleton via an interaction with β-catenin, a key protein involved in the pro-proliferative Wnt signaling pathway.…”
Section: Different Approaches To Restoring Tumour Suppressor Functionmentioning
confidence: 99%
“…(Refs. 2 , 23 , 24 , 25 , 26 , 27 ) VEZT Vezatin, adherens junctions transmembrane protein Transmembrane protein involved in maintaining adherens’ junctions. Gastric cancer In vitro Xie et al.…”
Section: Introductionmentioning
confidence: 99%