2015
DOI: 10.1016/j.biochi.2014.12.002
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Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression

Abstract: Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is importantly involved in the regulation of development, DNA damage response, and several human diseases. The molecular mechanisms that control the expression of hnRNP K are largely unknown. In the present study, we investigated the detailed mechanism of the transcriptional regulation of human hnRNP K gene. Two activating and one repressive elements located in the proximal segment of the transcriptional initiation site were identified in hnRNP K gene. A 19 b… Show more

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Cited by 8 publications
(6 citation statements)
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“…HNRNPK interacts with DNA, RNA, and various proteins to participate in transcription, translation, RNA splicing, DNA repair, and chromatin remodelling, and it plays key roles in the nervous system. HNRNPK, as an oestrogen-induced transcription factor, is involved in ovary development [56][57][58][59][60]. NIPBL, as a sex-related gene in chickens, is assembled on the W chromosome that has homologous sequences on chromosome Z [61].…”
Section: Discussionmentioning
confidence: 99%
“…HNRNPK interacts with DNA, RNA, and various proteins to participate in transcription, translation, RNA splicing, DNA repair, and chromatin remodelling, and it plays key roles in the nervous system. HNRNPK, as an oestrogen-induced transcription factor, is involved in ovary development [56][57][58][59][60]. NIPBL, as a sex-related gene in chickens, is assembled on the W chromosome that has homologous sequences on chromosome Z [61].…”
Section: Discussionmentioning
confidence: 99%
“…C9 repeat RNA leads to sequestration of a wide range of RBPs, conceivably including some RBPs that also regulate the translation of HNRNPK, which can impair the overall process to a greater extent. To illustrate this, the RNA-binding protein YBX1 is a regulator of HNRNPK [ 27 , 63 ] and is part of the C9orf72 repeat RNA interactome [ 12 , 25 ], which indicates the sequestration of YBX1 in RNA foci. Hence, a lack of translation, rather than increased degradation, is more conceivable to be at the origin of reduced HNRNPK expression.…”
Section: Discussionmentioning
confidence: 99%
“…A recent study showed that the transcription factor octamer-binding transcription factor 4 (OCT4) regulates the expression of hnRNPA2/B1 in porcine trophectoderm cell lines using luciferase reporter assays [ 54 ]. Additionally, the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ÎșB)-RelA (p65 subunit) and specificity protein (Sp)-1 bind to the hnRNPD and hnRNPK promoters, respectively, as shown by chromatin immunoprecipitation (ChIP) and electrophoresis mobility shift assays (EMSA) in oral and breast cancer cells [ 55 , 56 ]. However, it remains unclear how the expression of hnRNP at the transcriptional level is regulated in non-cancer and immune cells.…”
Section: Structure and Regulation Of Hnrnpmentioning
confidence: 99%