Transcriptional Regulation of Pattern-Triggered Immunity in Plants

Li, Bo; Meng, Xiangzong; Shan, Libo; He, Ping

doi:10.1016/j.chom.2016.04.011

Cited by 265 publications

(204 citation statements)

References 80 publications

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“…Transcriptional reprogramming is a hallmark of PRR signaling as most of the events on the plasma membrane during PAMP perception ultimately lead to changes in the transcription of immune-related genes (Li et al, 2016). Activation of MAPKs during PRR signaling is a well-studied pathway that establishes a link between PRR activation and transcriptional reprogramming.…”

Section: Discussionmentioning

confidence: 99%

The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity

Lal

Nagalakshmi

Hurlburt

et al. 2018

Cell Host & Microbe

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113

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SUMMARY Plants employ cell-surface pattern recognition receptors (PRRs) to detect pathogens. Although phytohormones produced during PRR signaling play an essential role in innate immunity, a direct link between PRR activation and hormone regulation is unknown. EFR is a PRR that recognizes bacterial EF-Tu and activates immune signaling. Here we report that EFR regulates the phytohormone jasmonic acid (JA) through direct phosphorylation of a receptor-like cytoplasmic kinase, BIK1. The BIK1 structure revealed that the EFR-phosphorylated sites reside on a uniquely extended loop away from the BIK1 kinase core domain. Phosphomimetic mutations of these sites resulted in increased phytohormones and enhanced resistance to bacterial infections. In addition to its documented plasma membrane localization, BIK1 also localizes to the nucleus and interacts directly with WRKY transcription factors involved in the JA and salicylic acid (SA) regulation. These findings demonstrate the mechanistic basis of signal transduction from PRR to phytohormones, mediated through a PRR-BIK1-WRKY axis.

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Section: Discussionmentioning

confidence: 99%

The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity

Lal

Nagalakshmi

Hurlburt

et al. 2018

Cell Host & Microbe

Self Cite

113

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“…Apparently, the transcriptional reprogramming triggered by different MAMPs or DAMPs also largely overlaps (82). …”

Section: Early Pattern Recognition Receptor Signaling Eventsmentioning

confidence: 99%

“…PTI elicitation induces rapid, dynamic, and global transcriptional changes of plant genes involved in a broad range of biological functions (82). Specific transcription factors directly phosphorylated by MAPKs or acting downstream of Ca 2+ signaling have been shown to play a role in regulating MAMP-responsive gene expression.…”

Section: Early Pattern Recognition Receptor Signaling Eventsmentioning

confidence: 99%

From Chaos to Harmony: Responses and Signaling upon Microbial Pattern Recognition

Xiao

Feng

et al. 2017

Annu. Rev. Phytopathol.

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434

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Pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs) are detected as nonself by host pattern recognition receptors (PRRs) and activate pattern-triggered immunity (PTI). Microbial invasions often trigger the production of host-derived endogenous signals referred to as danger-or damage-associated molecular patterns (DAMPs), which are also perceived by PRRs to modulate PTI responses. Collectively, PTI contributes to host defense against infections by a broad range of pathogens. Remarkable progress has been made toward demonstrating the cellular and physiological responses upon pattern recognition, elucidating the molecular, biochemical, and genetic mechanisms of PRR activation, and dissecting the complex signaling networks that orchestrate PTI responses. In this review, we present an update on the current understanding of how plants recognize and respond to nonself patterns, a process from which the seemingly chaotic responses form into a harmonic defense.

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“…For PRR-triggered defenses, we focus on early signaling mediated by PRRs. Readers are referred to several excellent reviews on the regulation of downstream signaling, such as transcriptional controls (Bigeard et al, 2015;Couto and Zipfel, 2016;Li et al, 2016b). We also discuss how pathogen effectors interfere with early PRR signaling to inhibit defenses and how pathogen effectors enhance virulence by manipulating RLKs that do not function as PRRs.…”

Section: Introductionmentioning

confidence: 99%