2016
DOI: 10.1007/978-1-4939-6539-7_7
|View full text |Cite
|
Sign up to set email alerts
|

Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression

Abstract: Tumor necrosis factor-α-inducible protein 8 (TNFAIP8) is the first discovered oncogenic and an anti-apoptotic member of a conserved TNFAIP8 or TIPE family of proteins. TNFAIP8 mRNA is induced by NF-kB, and overexpression of TNFAIP8 has been correlated with poor prognosis in many cancers. Downregulation of TNFAIP8 expression has been associated with decreased pulmonary colonization of human tumor cells, and enhanced sensitivities of tumor xenografts to radiation and docetaxel. Here we have investigated the effe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
46
1

Year Published

2016
2016
2022
2022

Publication Types

Select...
5
1
1

Relationship

0
7

Authors

Journals

citations
Cited by 36 publications
(51 citation statements)
references
References 37 publications
4
46
1
Order By: Relevance
“…SGK1 and TNFAIP8 are two ENZ-downregulated and OLA upregulated anti-apoptotic genes identified in this study and knockdown of either gene was proved to have significant synergistic effect with PARP inhibition as regard to apoptotic cell death. These results suggest that downregulation of SGK1 and TNFAIP8 by ENZ prior to OLA treatment is, at least, one of the mechanisms underlying the superior effect of lead-in ENZ+OLA over concomitant ENZ+OLA; they are also consistent with growing evidence that links SGK1 and TNFAIP8 to cancer cell survival, metastasis and chemo- and radio-resistance (3034). …”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…SGK1 and TNFAIP8 are two ENZ-downregulated and OLA upregulated anti-apoptotic genes identified in this study and knockdown of either gene was proved to have significant synergistic effect with PARP inhibition as regard to apoptotic cell death. These results suggest that downregulation of SGK1 and TNFAIP8 by ENZ prior to OLA treatment is, at least, one of the mechanisms underlying the superior effect of lead-in ENZ+OLA over concomitant ENZ+OLA; they are also consistent with growing evidence that links SGK1 and TNFAIP8 to cancer cell survival, metastasis and chemo- and radio-resistance (3034). …”
Section: Discussionsupporting
confidence: 85%
“…Both SGK1 and TNFAIP8 reportedly participate in apoptosis evasion, cell survival, chemo resistance and tumor progression (Fig. 5E) (3033) (34). Western blotting analysis validated select ENZ- and OLA-upregulated pro-apoptotic genes and ENZ-downregulated and OLA-upregulated SGK1 and TNFAIP8 (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Downstream signaling includes Rho‐GTPase, Ras‐GTPases and Akt. EphB3, engaged in cytoskeleton organization, is upregulated in colorectal cancer . Other activated RTK that could particularly contribute to the activation of cld7kd cells are INSR1 having docking sites for adaptor proteins with src‐2 domains .…”
Section: Discussionmentioning
confidence: 99%
“…EphB3, engaged in cytoskeleton organization, is upregulated in colorectal cancer. 48 Other activated RTK that could particularly contribute to the activation of cld7kd cells are INSR1 having docking sites for adaptor proteins with src-2 domains. 49 Insulin-like growth factor receptor (IGF1R) highly expressed in many cancer, is engaged in PI3K/Akt, MAPK and JNK cascade activation and IGF2R in TGFβ activation.…”
Section: The Impact Of Cic-tex On Cld7kd-non-cicmentioning
confidence: 99%
“…These appear upstream of KIF1B, TNFAIP8, PNN, FCF1, and PUDP, the first three of which have previously been associated with cancer. [57][58][59] Furthermore, four out of these five mutations are predicted by deepSEA to have a significant functional impact. Thus, the powerful filtering provided by differential ASE makes it possible to focus on only the subset of mutations that are potentially functional in whole genome sequencing.…”
Section: Functional Noncoding Mutations Lead To Differential Allele-smentioning
confidence: 99%