Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson’s Disease

Семенова, Екатерина Юрьевна; Vlasov, Ivan N.; Partevian, Suzanna A.; Rosinskaya, Anna V.; Rybolovlev, Ivan N.; Slominsky, Petr; Шадрина, М. И.; Alieva, Anelya Kh.

doi:10.3390/cells11162599

Cited by 4 publications

(4 citation statements)

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“…Table 2 shows that untreated PD patients showed a statistically significant decrease in MTA1 transcript levels. At the same time, the expression of MTA1 increased 1.5-fold in twins with PD relative to healthy twins [24]. The data we obtained can be explained by the fact that the decrease in MTA1 mRNA levels in the early stages of pathogenesis may be a consequence of DAergic neuronal death.…”

Section: Discussionmentioning

confidence: 51%

“…In the present study, gene expression changes of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT were analyzed in the peripheral blood of treated and untreated patients with early stages of PD. In our previous work, we performed a transcriptome analysis in the peripheral blood of three pairs of monozygotic twins discordant for PD, which revealed a significant increase in gene expression of ADORA2A, MTA1, and PTGDS in twins with PD [24]. As shown in Table 2, significant results in the group of patients with early stages of PD were obtained for the ADORA2A and MTA1 genes.…”

Section: Discussionmentioning

confidence: 93%

“…Our previous studies have resulted in the identification of potential candidate PD genes. Previously, we found a significant change in the expression of three genes associated with circadian rhythms, ADORA2A, MTA1, and PTGDS, in the peripheral blood of twins with PD [24], as well as PTGS2, associated with inflammatory processes, in fibroblast samples from twins with PD [25]. When studying mice with an MPTP-induced model of the early stage of PD, we obtained interesting results on changes in the expression of the NSF gene, the protein product of which is involved in transport processes [26].…”

Section: Introductionmentioning

confidence: 89%

“…Primer and probe sequence design was produced using Beacon designer 7.0 software (Premier Biosoft International, Palo Alto, CA, United States) and nucleotide sequences of the candidate genes MTA1, ADORA2A, PTGDS, AHCY, HNMT, NSF, and PTGS2 and housekeeping genes SARS1 and PSMD6 from the NCBI database [35]. The sequences of gene-specific primers and probes for the MTA1, ADORA2A, PTGDS, SARS1, and PSMD6 genes are listed in our previous work [24]. The sequences of gene-specific primers and probes for the HNMT, NSF, and PTGS2 genes are presented in Table 1.…”

Section: Statistical and Bioinformatic Datamentioning

confidence: 99%

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Analysis of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson’s Disease

Semenova,

Partevian,

Shulskaya

et al. 2023

BioMed Research International

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Parkinson’s disease (PD) is a common chronic, age-related neurodegenerative disease. This disease is characterized by a long prodromal period. In this context, it is important to search for the genes and mechanisms that are involved in the development of the pathological process in the earliest stages of the disease. Published data suggest that blood cells, particularly lymphocytes, may be a model for studying the processes that occur in the brain in PD. Thus, in the present work, we performed an analysis of changes in the expression of the genes ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT in the peripheral blood of patients with early stages of PD (stages 1 and 2 of the Hoehn–Yahr scale). We found significant and PD-specific expression changes of four genes, i.e., MTA1, PTGS2, NSF, and HNMT, in the peripheral blood of patients with early stages of PD. These genes may be associated with PD pathogenesis in the early clinical stages and can be considered as potential candidate genes for this disease. Altered expression of the ADORA2A gene in treated PD patients may indicate that this gene is involved in processes affected by antiparkinsonian therapy.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 89%

Section: Statistical and Bioinformatic Datamentioning

confidence: 99%

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Analysis of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson’s Disease

Semenova,

Partevian,

Shulskaya

et al. 2023

BioMed Research International

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Phenotypic and Transcriptomic Analysis Revealed a Lack of Risk Perception by Native Tadpoles Toward Novel Non‐Native Fish

Wang,

Zhu,

et al. 2024

Ecology and Evolution

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The introduction of alien species poses a serious threat to native biodiversity, and mountain lake systems in the southwest of China are particularly vulnerable to the introduction of non‐native fish. The prey naivety hypothesis states that native species may not be able to recognize novel introduced species due to a lack of common evolutionary background and therefore become easy targets, so the impacts of non‐native fish on mountain endemic amphibians need to be urgently assessed. In an ex‐situ experiment, we exposed the tadpoles of the Chaochiao Brown Frog (Rana chaochiaoensis), endemic to western China, to kairomones of both native and translocated fish species, and their phenotypic and genetic response patterns were compared. The results revealed significant phenotypic plasticity responses in total length (TOL), tail length (TL), and tail muscle width (TW) of tadpoles induced by native fish kairomone, while tadpoles exposed to translocated fish kairomone exhibited weaker phenotypic changes. At the transcriptional level, the number of differently expressed genes (DEGs) in the native fish treatment was 3.1‐fold (liver) and 52.6‐fold (tail muscle) higher than in the translocated fish treatment, respectively. There were more unique DEGs in the native fish treatment, primarily enriched in terms and pathways related to stress response, energy metabolism, and muscle development. The study revealed a lack of risk perception by native tadpoles toward novel non‐native fish, providing new evidence for the prey naivety hypothesis from both phenotypic and molecular perspectives. Future conservation efforts should prioritize assessing the impacts of non‐native fish on alpine and subalpine threatened and narrowly distributed amphibians. Additionally, prevention, early warning, monitoring, and removal of non‐native fish should be carried out as soon as possible.

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Effect of nacre extract from pearl oyster shells against behavioral and psychological symptoms of dementia in senescence-accelerated mouse P8 (SAMP8)

Omachi,

Hasegawa

2024

Journal of Functional Foods

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Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson’s Disease

Cited by 4 publications

References 69 publications

Analysis of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson’s Disease

Analysis of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson’s Disease

Phenotypic and Transcriptomic Analysis Revealed a Lack of Risk Perception by Native Tadpoles Toward Novel Non‐Native Fish

Effect of nacre extract from pearl oyster shells against behavioral and psychological symptoms of dementia in senescence-accelerated mouse P8 (SAMP8)

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