Transcriptomic Heterogeneity of Alzheimer’s Disease Associated with Lipid Genetic Risk

Miao, Xiao; Liu, Weifeng; Fan, Bin; Lin, Honghuang

doi:10.1007/s12017-020-08610-6

Cited by 4 publications

(3 citation statements)

References 70 publications

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“…PDLIM5 is vital in regulating cell proliferation, differentiation, and fate decisions in multiple tissues and cell types [ 73 ]. Previous studies have reported that PDLIM5 is expressed in AD, T2DM, and MDD to affect the disease progression [ [ [74] , [75] , [76] ]]. The PDLIM5 gene encodes the PDZ and LIM domain protein 5.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Shared peripheral blood biomarkers for Alzheimer’s disease, major depressive disorder, and type 2 diabetes and cognitive risk factor analysis

Geng

Liu

Deng

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

“…It is thought to play a role in cardiomyocyte expansion and inhibition of postsynaptic growth of excitatory synapses. The contents of PDZ and LIM domain protein 5 were all less abundant than that in the normal groups in AD, T2DM, and MDD [ [ [74] , [75] , [76] ]].…”

Section: Discussionmentioning

confidence: 99%

Shared peripheral blood biomarkers for Alzheimer’s disease, major depressive disorder, and type 2 diabetes and cognitive risk factor analysis

Geng

Liu

Deng

et al. 2023

Heliyon

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“…Notably, PDLIM5 has been associated with multiple neuropsychiatric disorders, including major depression, bipolar disorder and schizophrenia (for review: Huang et al, 2020). Another study also showed an association between this gene and Alzheimer's disease (Miao, Liu, Fan, & Lin, 2020). Its exact role in human aggression, however, remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Genome‐wide DNA methylation analysis of aggressive behaviour: a longitudinal population‐based study

Pishva

Hove

Laroche

et al. 2023

Child Psychology Psychiatry

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Background Human aggression is influenced by an interplay between genetic predisposition and experience across the life span. This interaction is thought to occur through epigenetic mechanisms, inducing differential gene expression, thereby moderating neuronal cell and circuit function, and thus shaping aggressive behaviour. Methods Genome‐wide DNA methylation (DNAm) levels were measured in peripheral blood obtained from 95 individuals participating in the Estonian Children Personality Behaviours and Health Study (ECPBHS) at 15 and 25 years of age. We examined the association between aggressive behaviour, as measured by Life History of Aggression (LHA) total score and DNAm levels both assessed at age 25. We further examined the pleiotropic effect of genetic variants regulating LHA‐associated differentially methylated positions (DMPs) and multiple traits related to aggressive behaviours. Lastly, we tested whether the DNA methylomic loci identified in association with LHA at age 25 were also present at age 15. Results We found one differentially methylated position (DMP) (cg17815886; p = 1.12 × 10−8) and five differentially methylated regions (DMRs) associated with LHA after multiple testing adjustments. The DMP annotated to the PDLIM5 gene, and DMRs resided in the vicinity of four protein‐encoding genes (TRIM10, GTF2H4, SLC45A4, B3GALT4) and a long intergenic non‐coding RNA (LINC02068). We observed evidence for the colocalization of genetic variants associated with top DMPs and general cognitive function, educational attainment and cholesterol levels. Notably, a subset of the DMPs associated with LHA at age 25 also displayed altered DNAm patterns at age 15 with high accuracy in predicting aggression. Conclusions Our findings highlight the potential role of DNAm in the development of aggressive behaviours. We observed pleiotropic genetic variants associated with identified DMPs, and various traits previously established to be relevant in shaping aggression in humans. The concordance of DNAm signatures in adolescents and young adults may have predictive value for inappropriate and maladaptive aggression later in life.

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Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC

Wang

Sun

et al. 2022

Acta Pharmacol Sin

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Transcriptomic Heterogeneity of Alzheimer’s Disease Associated with Lipid Genetic Risk

Cited by 4 publications

References 70 publications

Shared peripheral blood biomarkers for Alzheimer’s disease, major depressive disorder, and type 2 diabetes and cognitive risk factor analysis

Shared peripheral blood biomarkers for Alzheimer’s disease, major depressive disorder, and type 2 diabetes and cognitive risk factor analysis

Genome‐wide DNA methylation analysis of aggressive behaviour: a longitudinal population‐based study

Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC

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