Transcriptomic profiles of the upper olfactory rosette in cultured and wild Senegalese sole ( Solea senegalensis ) males

Fatsini, Elvira; Bautista, Rocí­o; Manchado, Manuel; Duncan, Neil

doi:10.1016/j.cbd.2016.09.001

Cited by 24 publications

(20 citation statements)

References 81 publications

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“…Similarly, clade III zebrafish TAARs have undergone strong positive selection (Hussain et al, 2009). Thus, the profiles of TAAR expression appear to be evolutionarily determined by adaptive responses; indeed, there is now evidence that TAAR expression can either be influenced by habitat changes or determine habitat choice (Churcher et al, 2015;Fatsini et al, 2016), consistent with a role in the detection and response to migratory cues.…”

Section: A Evolution Of Trace Amine-associated Receptorsmentioning

confidence: 80%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

300

287

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Section: A Evolution Of Trace Amine-associated Receptorsmentioning

confidence: 80%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

300

287

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“…This reference transcriptome is considered a useful tool for deep sequencing studies to minimize data processing times without losing any significant information about regulatory pathways in the functional analysis (Hachero-Cruzado et al, 2014;Fatsini et al, 2016). Sequence comparisons of the reference transcriptome with the previously published transcriptome in T. lutea (Carrier et al, 2014) indicated an FIGURE 4 | Expression profiles of sod1, sod2, sod3, aryl, ccp, and dio during the growth of T. lutea.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Iodine-Related Molecular Processes in the Marine Microalga Tisochrysis lutea (Haptophyta)

et al. 2018

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Iodine metabolism is essential for the antioxidant defense of marine algae and in the biogeochemical cycle of iodine. Moreover, some microalgae can synthetize thyroid hormone-like compounds that are essential to sustain food webs. However, knowledge regarding iodine-related molecular processes in microalgae is still scarce. In this study, a de novo transcriptome of Tisochrysis lutea cultured under high iodide concentrations (5 mM) was assembled using both long and short reads. A database termed IsochrysisDB was established to host all genomic information. Gene expression analyses during microalgal growth showed that most of the antioxidant-(aryl, ccp, perox, sod1, sod2, sod3, apx3, ahp1) and iodide-specific deiodinase (dio) genes increased their mRNA abundance progressively until the stationary phase to cope with oxidative stress. Moreover, the increase of dio mRNA abundance in aging cultures indicated that this enzyme was also involved in senescence. Cell treatments with iodide modified the expression of perox whereas treatments with iodate changed the transcript levels of gpx1 and ccp. To test the dependence of perox on iodide, microalgae cells were treated with hydrogen peroxide (H 2 O 2 ) either in presence or absence of iodide observing that several genes related to reactive oxygen species (ROS) deactivation (perox, gpx1, apx2, apx3, ahp1, ahp2, sod1, sod3, and aryl) were transcriptionally activated although with some temporal differences. However, only the expression of perox was dependent on iodide levels indicating this enzyme, acquired by horizontal gene transfer (HGT), could act as a haloperoxidase. All these data indicate that T. lutea activates coordinately the expression of antioxidant genes to cope with oxidative stress. The identification of a phase-regulated deiodinase and a novel haloperoxidase provide new clues about the origin and evolution of thyroid signaling and the antioxidant role of iodine in the marine environment.

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“…By contrast, TAAR5–9 are tuned toward tertiary amines ( Ferrero et al, 2012 ) and are under strong positive selection pressures ( Hussain et al, 2009 ; Vallender et al, 2010 ), with a variety of species-specific isoforms identified ( Eyun et al, 2016 ). Such positive selection pressures may indicate an evolutionary role in environmental adaptation responses, and indeed the TAAR expression profiles of at least some species may respond to habitat changes ( Churcher et al, 2015 ; Fatsini et al, 2016 ). Furthermore, with the notable exception of TAAR1, TAARs have also now been confirmed as a new family of receptors involved in olfaction, which respond to volatile signaling molecules associated with diverse ecological contexts ( Liberles, 2015 ).…”

Section: Evolution and Genetics Of Human Taarsmentioning

confidence: 99%

Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders

Christian

Berry

2018

Front. Pharmacol.

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Trace amines and their receptors (trace amine-associated receptors; TAARs) are an emerging pharmacological target for the treatment of human disorders. While most studies have focused on their therapeutic potential for neurologic and psychiatric disorders, TAARs are also expressed throughout the periphery, including prominent expression in human leukocytes. Furthermore, recent independent, unbiased metabolomic studies have consistently identified one or more TAAR ligands as potential etiologic factors in inflammatory bowel disease (IBD). The putative role of TAARs in diseases such as IBD that are associated with hyperactive immune responses has not, however, previously been systematically addressed. Here, we review the current state of the knowledge of the effects of TAARs on leukocyte function, in particular in the context of mucosal epithelial cells that interface with the environment; developing a model whereby TAARs may be considered as a novel therapeutic target for disorders associated with dysregulated immune responses to environmental factors. In this model, we hypothesize that altered trace amine homeostasis results in hyperactivity of the immune system. Such loss of homeostasis can occur through many different mechanisms including TAAR polymorphisms and altered trace amine load due to changes in host synthesis and/or degradative enzymes, diet, or microbial dysbiosis. The resulting alterations in TAAR functioning can then lead to a loss of homeostasis of leukocyte chemotaxis, differentiation, and activation, as well as an altered ability of members of the microbiota to adhere to and penetrate the epithelial cell layers. Such changes would generate a pro-inflammatory state at mucosal epithelial barrier layers that can manifest as clinical symptomatology such as that seen in IBD. These alterations may also have the potential to induce systemic effects, which could possibly contribute to immunomodulatory disorders in other systems, including neurological diseases.

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Transcriptomic profiles of the upper olfactory rosette in cultured and wild Senegalese sole ( Solea senegalensis ) males

Cited by 24 publications

References 81 publications

Trace Amines and Their Receptors

Trace Amines and Their Receptors

Characterization of Iodine-Related Molecular Processes in the Marine Microalga Tisochrysis lutea (Haptophyta)

Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders

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