2018
DOI: 10.1016/j.brs.2018.06.009
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Transcutaneous auricular vagus nerve stimulation (taVNS) for improving oromotor function in newborns

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Cited by 25 publications
(14 citation statements)
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“…After obtaining parental consent, we enrolled 14 participants who were consulted for G-tube placement in a prospective, open-label phase 0 trial to determine the feasibility, safety, and potential clinical benefit of a novel taVNS-paired oromotor rehabilitation paradigm in neonates with oromotor dyscoordination. We reported on five of the participants in this trial in an earlier brief communication (Badran et al, 2018b). Our primary clinical outcomes were improved PO feeding volumes and attaining full PO feeds adequate for discharge, thereby avoiding G-tube implantation (Figure 1).…”
Section: Study Overviewmentioning
confidence: 99%
“…After obtaining parental consent, we enrolled 14 participants who were consulted for G-tube placement in a prospective, open-label phase 0 trial to determine the feasibility, safety, and potential clinical benefit of a novel taVNS-paired oromotor rehabilitation paradigm in neonates with oromotor dyscoordination. We reported on five of the participants in this trial in an earlier brief communication (Badran et al, 2018b). Our primary clinical outcomes were improved PO feeding volumes and attaining full PO feeds adequate for discharge, thereby avoiding G-tube implantation (Figure 1).…”
Section: Study Overviewmentioning
confidence: 99%
“…Available data from human studies describing regional brain activation in response to non-invasive VNS varies substantially from study to study (Kraus et al, 2007; Frangos et al, 2015; Yakunina et al, 2017; Badran et al, 2018a). Moreover, human studies using tVNS at the tragus failed to demonstrate significant activation of the locus coeruleus, a key brainstem nucleus in the actions of VNS, compared to sham stimulation (Yakunina et al, 2017; Badran et al, 2018b). These studies may explain the reduced efficacy of human studies with non-invasive VNS compared to cervical VNS (Bauer et al, 2016; Barbella et al, 2018).…”
Section: Non-invasive Vagus Nerve Stimulationmentioning
confidence: 99%
“…We have recently shown invasive VNS to have beneficial effects on human executive functions, specifically working memory (Sun et al, 2017b ), suggesting that VNS might be useful in the treatment of cognitive impairment. Considering the costs and risks involved in invasive stimulation, it is of great interest to determine whether a safer non-invasive stimulation, transcutaneous vagus nerve stimulation (tVNS; Badran et al, 2018b ; Redgrave et al, 2018 ), has similar potential for enhancing executive functions.…”
Section: Introductionmentioning
confidence: 99%