Transcutaneous periorbital electrical stimulation in the treatment of dry eye

Pedrotti, Emilio; Bosello, Francesca; Fasolo, Adriano; Frigo, Anna Chiara; Marchesoni, Ivan; Ruggeri, Alfredo; Marchini, Giorgio

doi:10.1136/bjophthalmol-2016-308678

Cited by 25 publications

(40 citation statements)

References 16 publications

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“…TES was initially described as an effective treatment for DE by Pedrotti et al in 2016 (18). A total of 27 patients with DE underwent TES with electrodes placed onto the periorbital region of both eyes.…”

Section: Discussionmentioning

confidence: 99%

“…The second hypothesis may account for both the subjective and objective results. This hypothesis is that TES can produce quantum molecular resonance (QMR), stimulate the lacrimal system, and reactivate the lacrimal and meibomian gland tissue (18), thus promoting the secretion of tears and increasing the thickness of the lipid and mucin layers (36). QMR creates energy to break the molecular bonds without increasing the kinetic energy of the hit molecules, thus not increasing the temperature and limiting the damage to the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Based on previous data ( 18 ), a power analysis was performed to determine the sample size required to obtain significant effects after the treatment. A dropout rate of 15% was predicted.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, TES was reported to have potential efficacy as a novel option for treating DE (18). However, clinical researches have been insufficient and no controlled comparative studies demonstrating the superiority of TES for DE have been conducted to date.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of transcutaneous electrical stimulation combined with artificial tears for the treatment of dry eye: A randomized controlled trial

Cai¹,

Zhang²

2020

Exp Ther Med

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There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES combined with sodium hyaluronate (SH)-containing artificial tears. A total of 52 patients (104 eyes) with DE were enrolled in this randomized controlled trial. The patients were randomized 1:1 to the TES + SH or SH group. The patients in the TES + SH group were treated with 20 sessions (5 sessions per week for 4 weeks), and each session lasted for 20 min. The treatment was continued for 4 weeks in all cases. The Ocular Surface Disease Index (OSDI), tear film breakup time (BUT), Schirmer's I test and corneal fluorescein scores were used to assess treatment efficacy. A total of 90 eyes of 45 patients completed all aspects of the study: 22 patients (44 eyes) in the TES + SH group and 23 patients (46 eyes) in the SH group. There was no statistically significant difference in sex, age or course between the two groups. The mean OSDI scores, BUT, Schirmer's I test and corneal fluorescein scores exhibited a significant improvement in the TES + SH group compared with the SH group after treatment. No serious adverse events were recorded during TES treatment. In conclusion, TES combined with artificial tears appeared to be an effective treatment for DE. Therefore, TES may represent a new therapeutic option with promising potential applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Based on previous data ( 18 ), a power analysis was performed to determine the sample size required to obtain significant effects after the treatment. A dropout rate of 15% was predicted.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effectiveness of transcutaneous electrical stimulation combined with artificial tears for the treatment of dry eye: A randomized controlled trial

Cai¹,

Zhang²

2020

Exp Ther Med

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“…The pathogenesis is still unclear. At present, the main clinical application of tear substitutes to relieve dry eye symptoms, but cannot effectively cure dry eye syndrome [3]. In ammatory response, apoptosis, and changes in sex hormone levels are all associated with the development of dry eye syndrome, and in ammation is considered to be the most important factor in the pathogenesis of dry eye syndrome [4,5].…”

Section: Introductionmentioning

confidence: 99%

The expression of miRNA-146a-5p and its mechanism of treating dry eye syndrome

Yin

Zhang

et al. 2020

Preprint

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BACKGROUND Dry eye syndrome in which tear fluid quality or abnormality or kinetic abnormality is caused by many causes, resulting in decreased tear film stability. In recent years, more and more results from the studies indicate that miRNA alterations are involved in dry eye syndrome. And miRNA-146a-5p is a key regulator to regulate the inflammatory response. In this paper, we demonstrated whether miRNA-146a-5p could cure dry eye syndrome by regulating target genes based on network analysis. METHODS In this paper, we collected the blood of patients with dry eye disease served as model group, the blood of healthy people was served as control group. The expression of miRNA-146a-5p in the patients were detected by RT-PCR, the genes controled by miRNA-146a-5p were predicted by Targetscan, miRDB, miRWalk and PicTar databases, the genes regulated by miRNA-146a-5p which relative with dry eye disease were selected by draw venn diagram; RESULTS The comparison of the general information between patients and healthy people were no significant difference, and it indicated that the two groups were comparable. The results of databases showed that IRAK1 was one of the target genes regulated by miRNA-146a-5p and it is related to dry eye disease. The expression of miRNA-146a-5p was negatively related to IRAK1 mRNA and protein. While IRAK1 had positive correlation with IL-6, TNF-α and CBP proteins. CONCLUSIONS These results emphasized that miRNA-146a-5p could inhibit the expression of IRAK1, IL-6, TNF-α and CBP so as to help reduce the inflammatory response in dry eye syndrome.

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The expression of miRNA‐146a‐5p and its mechanism of treating dry eye syndrome

Yin

Zhang

et al. 2020

Clinical Laboratory Analysis

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Objective Dry eye syndrome in which tear fluid quality or abnormality, or kinetic abnormality is caused by various reasons, resulting in decreased tear film stability. In recent years, more and more results from the studies indicate that miRNA alterations are involved in dry eye syndrome. And miRNA‐146a‐5p is a key regulator to regulate the inflammatory response. In this paper, we demonstrated whether miRNA‐146a‐5p could cure dry eye syndrome by regulating target genes based on network analysis. Methods In current study, we collected the blood of patients with dry eye disease served as a model group; the blood of healthy people was served as control group. The expression of miRNA‐146a‐5p in the patients was detected by RT‐PCR, the genes controlled by miRNA‐146a‐5p were predicted by TargetScan, miRDB, miRWalk, and PicTar databases, and the genes regulated by miRNA‐146a‐5p which relative with dry eye disease were selected by drawing Venn diagram. Results The comparison of the general information between patients and healthy people was no significant difference, and it indicated that the two groups were comparable. The results of databases showed that IRAK1 was one of the target genes regulated by miRNA‐146a‐5p, and it is related to dry eye disease. The expression of miRNA‐146a‐5p was negatively related to IRAK1 mRNA and protein, while IRAK1 had a positive correlation with IL‐6, TNF‐α, and CBP proteins. Conclusion These results emphasized that miRNA‐146a‐5p could inhibit the expression of IRAK1, IL‐6, TNF‐α, and CBP to help reduce the inflammatory response in dry eye syndrome.

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Transcutaneous periorbital electrical stimulation in the treatment of dry eye

Abstract: Transcutaneous electrical stimulation was shown to improve DE, both subjectively and objectively, without any adverse effects and has the potential to enlarge the armamentarium for treating DE.

Cited by 25 publications

References 16 publications

Effectiveness of transcutaneous electrical stimulation combined with artificial tears for the treatment of dry eye: A randomized controlled trial

Effectiveness of transcutaneous electrical stimulation combined with artificial tears for the treatment of dry eye: A randomized controlled trial

The expression of miRNA-146a-5p and its mechanism of treating dry eye syndrome

The expression of miRNA‐146a‐5p and its mechanism of treating dry eye syndrome

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