Transcutaneous Sacral Electrical Stimulation for Chronic Functional Constipation

Iqbal, Fareed; Thomas, G. P.; Tan, Emile; Askari, Alan; Dastur, Jamasp K; Nicholls, John; Vaizey, C. J.

doi:10.1097/dcr.0000000000000523

Cited by 19 publications

(21 citation statements)

References 7 publications

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“…In 12 studies with 1805 patients, 14 , 16 , 17 , 21 , 22 , 24 - 26 , 31 , 33 , 34 , 36 pooled PAC-QOL was 1.97 (95% CI: 1.70-2.24) ( Figure 5 ). Publication bias was not evident (Egger P = .28).…”

Section: Resultsmentioning

confidence: 99%

“…After screening 426 records for eligibility, 24 studies representing 3786 unique patients were included in the meta-analysis. 5 , 14 - 36 The most common reasons for study exclusion were attributable to absence of main outcome reporting or Rome III FC diagnosis. A flow diagram of study identification and selection is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

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Normative Values for Colonic Transit Time and Patient Assessment of Constipation in Adults With Functional Constipation: Systematic Review With Meta-Analysis

Miller

Ibarra

Ouwehand

2017

Clin Med Insights Gastroenterol

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Availability of normative patient outcome data may assist in designing experiments and estimating sample sizes. The purpose of this review was to determine normative ranges for colonic transit time (CTT), Patient Assessment of Constipation-Symptoms (PAC-SYM), and Patient Assessment of Constipation-Quality of Life (PAC-QOL) in adults diagnosed with functional constipation per Rome III guidelines. Pooled estimates were derived from random-effects meta-analysis. Meta-regression was used to explore sources of heterogeneity among studies. A total of 24 studies (3786 patients) were included in the review. In 10 studies with 1119 patients, pooled CTT was 58 hours (95% confidence interval [CI]: 50-65 hours). Publication bias was not evident (Egger P = .51); heterogeneity was high (I2 = 92%, P < .001). In meta-regression, geographical location explained 57% of the between-study variance, with CTT significantly longer in studies conducted in Europe (71 hours) compared with Asia (49 hours) or the Americas (44 hours). In 9 studies with 2061 patients, pooled PAC-SYM was 1.70 (95% CI: 1.58-1.83). Publication bias was not evident (Egger P = .44). Heterogeneity was high (I2 = 90%, P < .001); however, no study or patient factor influenced PAC-SYM in meta-regression. In 12 studies with 1805 patients, pooled PAC-QOL was 1.97 (95% CI: 1.70-2.24). Publication bias was not evident (Egger P = .28); heterogeneity was high (I2 = 98%, P < .001). In meta-regression, age explained 52% of the between-study variance, with older age associated with lower PAC-QOL scores. Overall, in adults diagnosed with functional constipation per Rome III criteria, significant heterogeneity in CTT, PAC-SYM, and PAC-QOL exists among studies. Variability among studies may be explained by geography and patient factors.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Normative Values for Colonic Transit Time and Patient Assessment of Constipation in Adults With Functional Constipation: Systematic Review With Meta-Analysis

Miller

Ibarra

Ouwehand

2017

Clin Med Insights Gastroenterol

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“…The results of the 3 studies were in line with other studies despite including different population. [ 21 – 24 ]…”

Section: Discussionmentioning

confidence: 99%

A systematic review of clinical studies on electrical stimulation therapy for patients with neurogenic bowel dysfunction after spinal cord injury

Deng

Dong

Liu³

et al. 2018

Medicine

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“…Clinical results are similar to gastric banding [ 96 ] Lower gastrointestinal tract dysfunctions include both hypomotility (constipation) and hypermotility (diarrhea and dumping syndromes). Digital stimulation of perianal cutaneous mechanoreceptors has long been used by paraplegic patients to stimulate fecal emptying, providing a basis for transcutaneous electrical stimulation [ 97 ]. Reduced intestinal motility has been noted in animal experiments on gastric stimulation, but clinical syndromes are mostly transient and/or respond well to drugs …”

Section: Case Studiesmentioning

confidence: 99%

Neural Prosthetics:A Review of Empirical vs. Systems Engineering Strategies

Loeb
¹

2018

Applied Bionics and Biomechanics

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Implantable electrical interfaces with the nervous system were first enabled by cardiac pacemaker technology over 50 years ago and have since diverged into almost all of the physiological functions controlled by the nervous system. There have been a few major clinical and commercial successes, many contentious claims, and some outright failures. These tend to be reviewed within each clinical subspecialty, obscuring the many commonalities of neural control, biophysics, interface materials, electronic technologies, and medical device regulation that they share. This review cites a selection of foundational and recent journal articles and reviews for all major applications of neural prosthetic interfaces in clinical use, trials, or development. The hard-won knowledge and experience across all of these fields can now be amalgamated and distilled into more systematic processes for development of clinical products instead of the often empirical (trial and error) approaches to date. These include a frank assessment of a specific clinical problem, the state of its underlying science, the identification of feasible targets, the availability of suitable technologies, and the path to regulatory and reimbursement approval. Increasing commercial interest and investment facilitates this systematic approach, but it also motivates projects and products whose claims are dubious.

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Transcutaneous Sacral Electrical Stimulation for Chronic Functional Constipation

Abstract: Continuous transcutaneous sacral stimulation in the short term appears to be ineffective for chronic constipation. Larger well-powered studies with intermittent stimulation regimens are required to investigate this further.

Cited by 19 publications

References 7 publications

Normative Values for Colonic Transit Time and Patient Assessment of Constipation in Adults With Functional Constipation: Systematic Review With Meta-Analysis

Normative Values for Colonic Transit Time and Patient Assessment of Constipation in Adults With Functional Constipation: Systematic Review With Meta-Analysis

A systematic review of clinical studies on electrical stimulation therapy for patients with neurogenic bowel dysfunction after spinal cord injury

Neural Prosthetics:A Review of Empirical vs. Systems Engineering Strategies

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