2020
DOI: 10.3390/polym12061392
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Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment

Abstract: The transdermal delivery of therapeutic agents amplifying a local concentration of active molecules have received considerable attention in wide biomedical applications, especially in vaccine development and medical beauty. Unlike oral or subcutaneous injections, this approach can not only avoid the loss of efficacy of oral drugs due to the liver’s first-pass effect but also reduce the risk of infection by subcutaneous injection. In this study, a magneto-responsive transdermal composite microneedle (MNs) with … Show more

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Cited by 52 publications
(23 citation statements)
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“…The distribution of the number of studies by characterization technique is detailed in Figure S2. In parallel, few studies characterized the devices with Fourier transform infrared spectroscopy (FTIR, n = 2) [55,64], X-ray diffraction (XRD, n = 2) [55,64], differential scanning calorimetry (DSC, n = 3) [55,64,65], and thermal gravimetric analysis (TGA, n = 2) [65,66] techniques. In comparison, FTIR, XRD, and DSC techniques were applied to nanostructured system characterization (Figure S1) in 11, 12, and 9 studies, respectively.…”
Section: Methods Employed In Quality Controlmentioning
confidence: 99%
See 1 more Smart Citation
“…The distribution of the number of studies by characterization technique is detailed in Figure S2. In parallel, few studies characterized the devices with Fourier transform infrared spectroscopy (FTIR, n = 2) [55,64], X-ray diffraction (XRD, n = 2) [55,64], differential scanning calorimetry (DSC, n = 3) [55,64,65], and thermal gravimetric analysis (TGA, n = 2) [65,66] techniques. In comparison, FTIR, XRD, and DSC techniques were applied to nanostructured system characterization (Figure S1) in 11, 12, and 9 studies, respectively.…”
Section: Methods Employed In Quality Controlmentioning
confidence: 99%
“…In complement to the device formed by the combination of dissolvable polymers and a nanostructured system, the drug and protein release process can be promoted through external stimuli such as iontophoresis and magnetism fields as well as be applied to potentiate the therapy as near-infrared-light (NIR). Among the studies included in this review, only eight described the use of external stimuli, of which five studies corresponded to NIR [33][34][35][36]43], one to photodynamic therapy [85], one to iontophoresis [23], and one to magnetic fields [66]. The tests performed to evaluate the effects of these stimuli on the nanostructured systems and devices are presented in Table S2.…”
Section: External Stimulus Applicationmentioning
confidence: 99%
“… [ 65 ] Minoxidil Metallic nanoparticles (iron oxide) 150–200 Mice C57BL/6 The mice’s hair density exhibited an 800% improvement after being treated by microneedle, followed by an external magnetic field, compared to the mice without any treatments. [ 66 ] Minoxidil and Diphencyprone Liposomes and niosomes 200–300 and 750–3200 Fresh human skin obtained fromm abdominoplasty Liposome formulations increased drugs skin penetration compared to a propylene glycol–water–ethanol solution. [ 67 ] Minoxidil and Finasteride Nanostructured lipid carriers 200 Porcine ear skin Nanostructured lipid carriers loaded with minoxidil and finasteride had low penetration levels through pig ear skin under physiological conditions, which would avoid a toxic, systemic exposure.…”
Section: Challenges Of Current Topical Treatments For Alopeciamentioning
confidence: 99%
“…Using DLP 3DP, Seng Han et al developed a personalized MN eye patch to create microchannels to improve permeation of antiwrinkle peptides ( Figure 3 d) [ 125 ]. Other research groups utilized DLP 3D printing technology for the fabrication of MN master molds [ 133 , 134 , 135 ]. El-Sayed et al successfully used a desktop DLP 3D printer to produce positive master molds.…”
Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning
confidence: 99%