Transdermal Delivery

Franz, Thomas; Tojo, Kakuji; Shah, Kishore R.; Kydonieus, Agis F.

doi:10.1201/9780203735022-8

Cited by 6 publications

(3 citation statements)

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“…DELIVERY [12][13][14][15] The interaction of these factors -the physicochemical properties of the medication, (b) Physiological elements, and (c) formulation components and their interactionsdetermines the effectiveness of topical drug delivery.…”

Section: Factors Affecting Topical Drugmentioning

confidence: 99%

Untitled

2024

AJP

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With a focus on sensible topical formulation techniques and the essential components of topical drug delivery systems, the goal of this review is to provide an overview of recent research. The advantage of administering medication topically is that it reaches the site of action directly and remains longer there. Topical medications are primarily administered through the skin, which is one of the body's most accessible and widely distributed organs. Topical medications are usually very sticky and uncomfortable to apply, which presents a number of challenges. Ointments, lotions, and creams are common topical medications. They also have a lower spreading coefficient, require rubbing, and have a stability problem when compared to other semisolid preparations in the main category. All of these factors have led to an increase in the use of gas in preparations for pharmaceutical and cosmetic uses. The surface tension between a 99% liquid-by-weight colloid and a network of macromolecules composed of minuscule amounts of the surrounding gelatinous substance immobilizes the colloid, forming a gel.

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Section: Factors Affecting Topical Drugmentioning

confidence: 99%

Untitled

2024

AJP

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“…"Cd" is the concentration of drug added to the donor chamber and "H" is the thickness of the skin. The diffusion coefficient (D), the permeability coefficient (Kp), the partition coefficient between the solution and skin the (K) were calculated according to equations given by Franz et al 1991 [33]. Figure 1.…”

Section: Permeation Data Analysismentioning

confidence: 99%

Nanosized ethanol based malleable liposomes of cytarabine to accentuate transdermal delivery: formulation optimization,in vitroskin permeation andin vivobioavailability

Raj

Ram

2018

Artificial Cells, Nanomedicine, and Biotechnology

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Cytarabine is a pyrimidine nucleoside analog used predominantly for acute myeloid leukemia (AML) and also for other indications, including acute lymphocytic leukemia, chronic myelogenous leukemia, and lymphoma by parenteral route due to its low oral bioavailability. Parenteral administration requires constant plasma level, monitoring for its fluctuation and poor patients compliances. Hence the objective of this work is to construct optimized nanosized malleable liposomes of cytarabine to accentuate transdermal delivery of drug to circumvent previously mentioned drawbacks. We also investigated its characteristics and therapeutic efficiency and attempted to systematically explore the penetration enhancing property. Well characterized ethanolic liposomes were also biologically tested for dermatological safety and systemic bioavailability. Ethanolic liposomes were found to be spherical having nanometric size with low polydispersity and high encapsulation efficiency. Skin permeation and deposition studies revealed significant enhancement. In vivo, skin irritation study of developed formulation showed no erythema or scaling vis-à-vis the liposomes. Blood profile of this novel formulation indicated lower lag time with the high amount of drug within 3-12 h after transdermal administration demonstrating the enhanced percutaneous penetration of cytarabine with no erythema, thus leading to patient's compliance by alternative delivery of drug for the treatment of leukemia.

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“…É um método não-invasivo que permite a intervenção contínua e possível de se evitar sobredose (ROBERTS & CROSS, 2002;CLEARY, 2003). Além do exposto, o sistema de liberação transdérmica tem vantagens sobre outros métodos de administração de fármacos, incluindo sua liberação direta no órgão afetado, duração prolongada da atividade (a administração dura por um período de tempo mais longo, proporcionando maior adesão do paciente ao tratamento) e redução dos efeitos adversos devido à otimização da concentração x tempo (entrega de ordem zero do fármaco) (BISSETT, 1987;FRANZ, TOJO & KYDONIEUS, 1991).…”

Section: Sistemas De Liberação Transdérmicaunclassified

Desenvolvimento, caracterização, avaliação da estabilidade e da penetração cutânea de nanopartículas de ácido ursólico incorporadas em formulação cosmética

Almeida¹

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Transdermal Delivery

Cited by 6 publications

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Nanosized ethanol based malleable liposomes of cytarabine to accentuate transdermal delivery: formulation optimization,in vitroskin permeation andin vivobioavailability

Desenvolvimento, caracterização, avaliação da estabilidade e da penetração cutânea de nanopartículas de ácido ursólico incorporadas em formulação cosmética

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