Transdermal delivery of curcumin via microemulsion

Sintov, Amnon

doi:10.1016/j.ijpharm.2015.02.005

Cited by 74 publications

(43 citation statements)

References 44 publications

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“…Microemulsions have been extensively explored for a variety of pharmaceutical applications, including dermal and transdermal drug delivery. [6][7][8][9] The use of these nanocarriers in skin drug delivery has been frequently exploited and has proven highly successful for the delivery of both hydrophilic and lipophilic compounds. 10 Most of the studies demonstrated that more pronounced cutaneous drug localization in skin layers rather than percutaneous permeation can be obtained with microemulsions.…”

Section: Introductionmentioning

confidence: 99%

Colloidal nanocarriers for the enhanced cutaneous delivery of naftifine: characterization studies and in vitro and in vivo evaluations

Erdal¹,

Özhan²,

Mat³

et al. 2016

IJN

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In topical administration of antifungals, the drugs should pass the stratum corneum to reach lower layers of the skin in effective concentrations. Thus, the formulation of antifungal agents into a suitable delivery system is important for the topical treatment of fungal infections. Nanosized colloidal carriers have gained great interest during the recent years to serve as efficient promoters of drug penetration into the skin. Microemulsions are soft colloidal nanosized drug carriers, which are thermodynamically stable and isotropic systems. They have been extensively explored for the enhancement of skin delivery of drugs. This study was carried out to exploit the feasibility of colloidal carriers as to improve skin transport of naftifine, which is an allylamine antifungal drug. The microemulsions were formulated by construction of pseudoternary phase diagrams and composed of oleic acid (oil phase), Kolliphor ® EL or Kolliphor ® RH40 (surfactant), Transcutol ® (cosurfactant), and water (aqueous phase). The plain and drug-loaded microemulsions were characterized in terms of isotropy, particle size and size distribution, pH value, refractive index, viscosity, and conductivity. The in vitro skin uptake of naftifine from microemulsions was studied using tape stripping technique in pig skin. The drug penetrated significantly into stratum corneum from microemulsions compared to its marketed cream ( P <0.05). Moreover, the microemulsion formulations led to highly significant amount of naftifine deposition in deeper layers of skin than that of commercial formulation ( P <0.001). Microemulsion–skin interaction was confirmed by attenuated total reflectance – Fourier transformed infrared spectroscopy data, in vitro. The results of the in vivo tape stripping experiment showed similar trends as the in vitro skin penetration study. Topical application of the microemulsion on human forearms in vivo enhanced significantly the distribution and the amount of naftifine penetrated into the stratum corneum as compared to the marketed formulation ( P <0.05). The relative safety of the microemulsion formulations was demonstrated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide viability test. This study indicated that the nanosized colloidal carriers developed could be considered as an effective and safe topical delivery system for naftifine.

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Section: Introductionmentioning

confidence: 99%

Colloidal nanocarriers for the enhanced cutaneous delivery of naftifine: characterization studies and in vitro and in vivo evaluations

Erdal¹,

Özhan²,

Mat³

et al. 2016

IJN

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“…The thermodynamic activity of drugs in ME with lower surfactant mixture content was demonstrated to be an important driving force for the release and the penetration of the drug into skin (22,23). The decreased concentration of surfactant in dispersed systems may also increase the rate of drug release and its permeation in the skin (24,25). Thus, the water content ranged between 50 and 70%, while that of the surfactant and cosurfactant ranged between 20 and 45%.…”

Section: Resultsmentioning

confidence: 99%

Preparation and evaluation of microemulsion-based transdermal delivery of Cistanche tubulosa phenylethanoid glycosides

Yang

et al. 2017

Molecular Medicine Reports

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The primary aim of the present study was to develop a novel microemulsion (ME) formulation to deliver phenylethanoid glycoside (PG) for use in skin lighteners and sunscreens. The oil phase was selected on the basis of drug solubility, while the surfactant and cosurfactant were screened and selected on the basis of their solubilizing capacity and the efficiency with which they formed MEs. Pseudoternary phase diagrams were constructed to evaluate ME regions and five formulations of oil-in-water MEs were selected as vehicles. In vitro skin permeation experiments were performed to optimize the ME formulation and to evaluate its permeability in comparison to that of saline solution. The physicochemical properties of the optimized ME and the permeating ability of PG delivered by this ME were also investigated. The optimized ME formulation was composed of isopropyl myristate (7%, w/w), Cremorphor EL (21%, w/w), propylene glycol (7%, w/w) and water (65%, w/w). The cumulative amount of PG that permeated through excised mouse skin when carried by ME was ~1.68 times that when PG was carried by saline solution only. The cumulative amount of PG in the microemulsion (4149.650±37.3 µg·cm−2) was significantly greater than that of PG in the saline solution (2288.63±20.9 µg·cm−2). Furthermore, the permeability coefficient indicated that optimized microemulsion was a more efficient carrier for transdermal delivery of PG than the control solution (8.87±0.49 cm/hx10−3 vs. 5.41±0.12 cm/hx10−3). Taken together, the permeating ability of ME-carried PG was significantly increased compared with saline solution.

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“…However, due to its high lipophilic character (logP: 5.01), isotretinoin tends to accumulate on the skin surface and in the upper stratum corneum, thus its penetration into the lower layers is limited, which restricts the efficiency of topical treatment 24 . Nano-sized colloidal carriers such as microemulsions are considered appropriate carriers due to the increment of partitioning and solubility of drug in stratum corneum, enhancement of thermodynamic activity of drug in the vehicle and/or increasing the permeability of skin 8,25 .…”

Section: Resultsmentioning

confidence: 99%