Transdermal delivery of vancomycin hydrochloride: Influence of chemical and physical permeation enhancers

Datta, Deepanjan; Panchal, Dhruvisha Sureshbhai; Venuganti, Venkata Vamsi Krishna

doi:10.1016/j.ijpharm.2021.120663

Cited by 28 publications

(10 citation statements)

References 21 publications

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“…However, DAB levels were detected in the skin for all the formulations. It is has been well established that the tape-stripped skin shows dramatic increases in the skin permeation of moderately water-soluble compounds such as caffeine [ 34 ], crisaborole [ 35 ] and vancomycin [ 36 ]. Likewise, diacetyl boldine permeation and skin retention across tape-stripped skin (with no stratum corneum) was very high compared to intact skin ( Figure 3 and Figure 4 ).…”

Section: Discussionmentioning

confidence: 99%

Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma

et al. 2023

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This study aimed to develop a microemulsion formulation for topical delivery of Diacetyl Boldine (DAB) and to evaluate its cytotoxicity against melanoma cell line (B16BL6) in vitro. Using a pseudo-ternary phase diagram, the optimal microemulsion formulation region was identified, and its particle size, viscosity, pH, and in vitro release characteristics were determined. Permeation studies were performed on excised human skin using Franz diffusion cell assembly. The cytotoxicity of the formulations on B16BL6 melanoma cell lines was evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay. Two formulation compositions were selected based on the higher microemulsion area of the pseudo-ternary phase diagrams. The formulations showed a mean globule size of around 50 nm and a polydispersity index of <0.2. The ex vivo skin permeation study demonstrated that the microemulsion formulation exhibited significantly higher skin retention levels than the DAB solution in MCT oil (Control, DAB-MCT). Furthermore, the formulations showed substantially higher cytotoxicity toward B16BL6 cell lines than the control formulation (p < 0.001). The half-maximal inhibitory concentrations (IC50) of F1, F2, and DAB-MCT formulations against B16BL6 cells were calculated to be 1 µg/mL, 10 µg/mL, and 50 µg/mL, respectively. By comparison, the IC50 of F1 was 50-fold lower than that of the DAB-MCT formulation. The results of the present study suggest that microemulsion could be a promising formulation for the topical administration of DAB.

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Section: Discussionmentioning

confidence: 99%

Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma

et al. 2023

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“…Previously, palmitic acid was used in transdermal formula of vancomycin to improve large-molecule permeation through the skin. 20,21 All films with sustainable release property were subjected to AlmarBlue ® and planktonic assay solution to monitor the antimicrobial activity of release ofloxacin. All prepared films show a strong antimicrobial and antibiofilm activity against biofilm-forming S. aureus and P. aeruginosa after incubation at 37 C for 24 h. Both bacterial viability and biofilm formed were <10% when compared with the control.…”

Section: Discussionmentioning

confidence: 99%

“…One possible reason for diffusion enhancement is the use of palmitic acid in film formulation. Previously, palmitic acid was used in transdermal formula of vancomycin to improve large‐molecule permeation through the skin 20 , 21 …”

Section: Discussionmentioning

confidence: 99%

The effect of polymeric films of hydroxypropyl methylcellulose (HPMC)/chitosan on ofloxacin release, diffusion, and biological activity

Jaber

Saadh

Obeid

2023

Polymer Engineering & Sci

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Infectious diseases caused by resistant bacteria have been investigated by several researchers recently. Ofloxacin is a quinolone antibiotic used against resistant microorganisms and in different routes of administration. Transdermal drug delivery is used to reduce drug toxicity, avoid first‐pass metabolism, and reduce fluctuations in drug concentration in the body. Ofloxacin was formulated in a transdermal polymeric formula using hydroxypropyl methyl cellulose (HPMC) and chitosan at different ratios in the presence of palmitic acid as a permeation enhancer. Physical characterization, drug release and diffusion, drug matrix association, and antimicrobial assay have been investigated using different techniques including HPLC, fourier‐transform infrared spectroscopy (FTIR), Franz cells diffusion, and UV spectroscopy. Ofloxacin release was successfully accomplished in many polymeric formulas containing a high ratio of HPMC with a maximum drug release of 53%. Formulas selected for antimicrobial assay indicate that sustained release patches have successfully inhibited microbial and biofilm growth with a percentage inhibition of more than 90%. In conclusion, antibiotics can be formulated in transdermal polymeric film to target skin infection and reduce drug toxicity and avoid drug first metabolism for drugs reaching systemic circulation which has a direct influence on drug activity.

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“…Peptide nucleic acids (PNAs) are neutral N-(2-aminoethyl)-glycine pseudo-peptides that mimic DNA by attaching the nucleobases. PNAs have emerged as particularly intriguing oligonucleotide probe alternatives for the development of electrochemical sensing, primarily due to the vastly differing electrical properties of their molecular backbones [ 80 , 81 , 82 , 83 ]. There are many more articles that may be cited in support of this claim, but the authors believe that the works that have tested actual samples should be given more weight than those that have just been considered as a model sequence using less complex synthetic oligonucleotides [ 84 , 85 ].…”

Section: Nucleic Acid-based Biosensorsmentioning

confidence: 99%

A Short Review on Miniaturized Biosensors for the Detection of Nucleic Acid Biomarkers

2023

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Even today, most biomarker testing is executed in centralized, dedicated laboratories using bulky instruments, automated analyzers, and increased analysis time and expenses. The development of miniaturized, faster, low-cost microdevices is immensely anticipated for substituting for these conventional laboratory-oriented assays and transferring diagnostic results directly onto the patient’s smartphone using a cloud server. Pioneering biosensor-based approaches might make it possible to test biomarkers with reliability in a decentralized setting, but there are still a number of issues and restrictions that must be resolved before the development and use of several biosensors for the proper understanding of the measured biomarkers of numerous bioanalytes such as DNA, RNA, urine, and blood. One of the most promising processes to address some of the issues relating to the growing demand for susceptible, quick, and affordable analysis techniques in medical diagnostics is the creation of biosensors. This article critically discusses a short review of biosensors used for detecting nucleic acid biomarkers, and their use in biomedical prognostics will be addressed while considering several essential characteristics.

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Transdermal delivery of vancomycin hydrochloride: Influence of chemical and physical permeation enhancers

Cited by 28 publications

References 21 publications

Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma

Topical Delivery of Diacetyl Boldine in a Microemulsion Formulation for Chemoprotection against Melanoma

The effect of polymeric films of hydroxypropyl methylcellulose (HPMC)/chitosan on ofloxacin release, diffusion, and biological activity

A Short Review on Miniaturized Biosensors for the Detection of Nucleic Acid Biomarkers

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