Transdermal Dihydrotestosterone Therapy and its Effects on Patients with Microphallus

Choi, Seung Kang; Han, Sang Won; Kim, Duk H.; Lignières, B. De

doi:10.1016/s0022-5347(17)35576-3

Cited by 61 publications

(46 citation statements)

References 15 publications

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“…The use of local genital or penile androgen creme has been suggested earlier in children before undergoing genital surgery (e.g., hypospadia repair) or for the treatment of microphallus [4,6,8,15,16,19,35]. This attempt was based on the fact that androgen receptor density in the penis and the genital skin is far higher before and during puberty than in adults [3,28,34].…”

Section: Discussionmentioning

confidence: 99%

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Schultheiss¹,

Hiltl²,

Meschi³

et al. 2000

World J Urol

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Androgens influence important central and peripheral mechanisms of the erectile system. The relevance of a moderate decrease of serum testosterone level for erectile dysfunction (ED) has not been clarified so far. The aim of our study was to offer an easy transcutaneous method of androgen application. A previous study on the pharmacokinetic profile of the testosterone gel applied, showed marked elevation of the serum levels of testosterone. In our study, 46 hypogonadal patients with ED and total lack of vaginal penetration applied testosterone gel (4 mg/day; supplied by Azupharma, Germany) to the penile skin twice a day over 6-8 weeks, after a run-in period with placebo gel of 2 weeks. All patients showed decreased testosterone serum levels (<3 ng/ml) in at least two morning samples over a period of 3 weeks before treatment. Psychogenic etiology was excluded by a sexual psychologist. Patient age was 37-69 years (mean 53.5). Three patients (6.5%) responded to placebo in the run-in phase and were withdrawn from further treatment. Fifteen patients (32.6%) showed improved erection, allowing penetration and sexual intercourse. Twenty-eight patients (60.9%) did not respond to therapy. Local genital skin irritation was not observed. Elevation of peripheral testosterone was not correlated to a positive therapy response. A success-rate of 32.6% in this group of patients after exclusion of psychogenic patients and placebo-responders seems to justify further investigations. A medication period of 6-8 weeks is most probably too short to induce imaginable regenerative effects of testosterone on the erectile system. We therefore suggest that future double-blind and placebo-controlled studies should be designed for a minimum of 3 months. Testosterone gel may be a cost effective form of androgen administration.

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Section: Discussionmentioning

confidence: 99%

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Schultheiss¹,

Hiltl²,

Meschi³

et al. 2000

World J Urol

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“…This hypothesis is supported by the observation that the administration of testosterone and 5a reductase inhibitor did not prevent decline in erectile function in orchiectomized rats while administration of testosterone or 5a-DHT did [11]. Furthermore, clinical studies [12,13] have shown that administration of 5a-DHT to infants and children with micropenis promotes penile growth.…”

Section: Androgens and Penile Developmentmentioning

confidence: 90%

Androgens and male sexual dysfunction

Mir¹,

Munárriz²

2006

Current Opinion in Endocrinology and Diabetes

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Purpose of reviewIt is generally accepted that androgens are critical for mood, cognition, sex differentiation, development of male sexual characteristics and maintenance of bone density and muscle/fat ratio. Their role in sexual function and in particular in erectile physiology, however, remains controversial. A careful review of preclinical and clinical studies on the role of androgens and male sexual function was conducted. Recent findingsPreclinical studies suggest that androgens modulate penile trabecular smooth muscle, neural and extracellular matrix integrity and adipocyte accumulation and distribution. In addition, androgens upregulate neural and endothelial nitric oxide synthase and phosphodiesterase type 5. Clinical studies document a relationship between androgens and erectile function, nocturnal erections and sexual desire and activity. Androgen ablation results in decreased erectile function, sexual desire and activity in many men. Testosterone treatment may be able to restore male sexual function. In addition, testosterone replacement may be able to improve erectile function in men who have failed phosphodiesterase type 5 inhibitors. SummaryThe literature supports that androgens modulate male sexual function. The exact mechanisms by which androgens exert their activity is not completely understood, but it seems that androgens modulate penile tissue integrity as well as nitric oxide synthase and phosphodiesterase type 5 expression and activity.

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“…Bayi demikian perlu dinilai ulang status seksnya. 4,9 Pengalaman klinis menunjukkan bahwa kunjungan untuk konsultasi mikropenis meningkat dari tahun ke tahun di Poliklinik Endokrinologi Anak RSCM. Terapi yang sampai dasar pubis dikatakan sebagai panjang penis.…”

Section: Pengukuran Penisunclassified

Pengobatan Testosteron pada Mikropenis

Tridjaja¹,

Batubara²,

Pulungan³

2016

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Mikropenis atau hipogenitalism adalah suatu keadaan penis dengan bentuk normal namun dengan ukuran kurang dari 2.5 SD di bawah rerata menurut umur dan status perkembangan pubertas. Pengukuran penis dilakukan secara fully stretched, menggunakan spatula kayu yang diletakkan sejajar dengan dorsum penis dan ditekan sampai simfisis pubis. Panjang penis adalah jarak dari simfisis pubis sampai ujung glans penis dan tidak dalam keadaan ereksi. Pengobatan mikropenis terhadap 23 anak dengan rerata usia 9.6 tahun dilakukan dengan pemberian testosteron ester intramuskular setiap 3 minggu sebanyak 4 kali. Pasca terapi penis bertambah panjang 85% dibandingkan sebelum terapi. Tidak terlihat adanya pertambahan usia tulang dengan protokol yang digunakan.Kata kunci: mikropenis, testosteron ester Sari

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Transdermal Dihydrotestosterone Therapy and its Effects on Patients with Microphallus

Cited by 61 publications

References 15 publications

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction

Androgens and male sexual dysfunction

Pengobatan Testosteron pada Mikropenis

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