Transdermal Drug Delivery System: formulation, development and evaluation-An overview

Abstract

In a transdermal drug delivery system the drug is applied in a relatively high dosage to the inside of a patch, which is worn on the skin for an extended period of time. Through a diffusion process, the drug enters the bloodstream directly through the skin. Since there is high concentration on the patch and low concentration in the blood, the drug will keep diffusing into the blood for a long period of time, maintaining the constant concentration of drug in the blood flow. Transdermal drug delivery system was introduced to overcome the difficulties of drug delivery through oral route. The conventional oral dosage forms have significant setbacks of poor bioavailability due to hepatic first pass metabolism. To improve characters of transdermal drug delivery system (TDDS) was emerged, which will improve the therapeutic efficacy and safety of drugs by specific sites within the body, thereby reducing both the size and number of doses. This review article describes the methods of preparation of different types of transdermal patches such as matrix patches, reservoir type, membrane matrix, drug-in-adhesive patches and micro reservoir patches.

Development and Characterization of Transdermal Delivery System of Doxazosin Mesylate

“…The patches prepared using various polymer combinations were evaluated for following parameters [20][21][22][23][24].…”

Formulation Aspects, Approaches and Evaluation of Transdermal Drug Delivery System: A Concise Review

“…The drug is surface coated on the microneedles to aid in rapid absorption. They are used in development of cutaneous vaccines for tetanus and influenza 24 .…”

Multifunctional chitosan-coated poly(lactic-co-glycolic acid) nanoparticles for spatiotemporally controlled codelivery of ceramide and C-phycocyanin to treat atopic dermatitis

“…20,21 Nano-sized drug delivery carriers have been developed with a focus on minimizing side effects, maximizing the target specificity of drug delivery, and controlled drug release according to time or external stimuli. 22–24 The US Food and Drug Administration–approved poly(lactic-co-glycolic acid) (PLGA), a copolymer of lactic acid and glycolic acid, is biocompatible and biodegradable and is widely used as a biological material. 25 In addition, PLGA has been used actively in nanodrug delivery system studies because it has a sustained release property.…”