Transdermal Drug Delivery Systems: Skin Perturbation Devices

Brown, Marc; Traynor, Matthew J.; Martin, Gary P.; Akomeah, Franklin K.

doi:10.1007/978-1-59745-210-6_5

Cited by 82 publications

(46 citation statements)

References 92 publications

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“…13,14 The velocity field integrated with heat transfer for Newtonian systems has been studied by various researchers in micro-chip cooling, 15,16 microscale heat exchanger, 17 micro-electronic-mechanical-systems (MEMS), 18 microreactors, 19 etc. The corresponding mass transfer problems have applications in transdermal drug delivery, 20,21 electrolyte transport in fuel cells, 22 transport in hydrogel, 23 electrokinetic separation, 24 etc. These applications include study of transport processes involving both fluid flow and mass transfer in a microchannel with porous wall or membrane.…”

Section: Introductionmentioning

confidence: 99%

Effects of non-Newtonian power law rheology on mass transport of a neutral solute for electro-osmotic flow in a porous microtube

Mondal

2013

Biomicrofluidics

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Mass transport of a neutral solute for a power law fluid in a porous microtube under electro-osmotic flow regime is characterized in this study. Combined electroosmotic and pressure driven flow is conducted herein. An analytical solution of concentration profile within mass transfer boundary layer is derived from the first principle. The solute transport through the porous wall is also coupled with the electro-osmotic flow to predict the solute concentration in the permeate stream. The effects of non-Newtonian rheology and the operating conditions on the permeation rate and permeate solute concentration are analyzed in detail. Both cases of assisting (electro-osmotic and poiseulle flow are in same direction) and opposing flow (the individual flows are in opposite direction) cases are taken care of. Enhancement of Sherwood due to electro-osmotic flow for a non-porous conduit is also quantified. Effects if non-Newtonian rheology on Sherwood number enhancement are observed. V C 2013 AIP Publishing LLC. [http://dx

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Section: Introductionmentioning

confidence: 99%

Effects of non-Newtonian power law rheology on mass transport of a neutral solute for electro-osmotic flow in a porous microtube

Mondal

2013

Biomicrofluidics

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“…Newer designs of powder injection devices continue to be developed to address the limitations of current versions [183]. Several additional devices have been developed to enhance skin permeability to drug, especially by removal of the stratum corneum [184]. These include use of an abrasive pad [185], microdermabrasion [186], thermal ablation [187], or lasers [188] to disrupt the stratum corneum.…”

Section: Discussionmentioning

confidence: 99%

Engineering Approaches to Transdermal Drug Delivery: A Tribute to Contributions of Prof. Robert Langer

Mitragotri

2013

Skin Pharmacol Physiol

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Transdermal drug delivery continues to provide an advantageous route of drug administration over injections. While the number of drugs delivered by passive transdermal patches has increased over the years, no macromolecule is currently delivered by the transdermal route. Substantial research efforts have been dedicated by a large number of researchers representing varied disciplines including biology, chemistry, pharmaceutics and engineering to understand, model and overcome the skin's barrier properties. This article focuses on engineering contributions to the field of transdermal drug delivery. The article pays tribute to Prof. Robert Langer, who pioneered the engineering approach towards transdermal drug delivery. Over a period spanning nearly 25 years since his first publication in the field of transdermal drug delivery, Bob Langer has deeply impacted the field by quantitative analysis and innovative engineering. At the same time, he has inspired several generations of engineers by collaborations and mentorship. His scientific insights, innovative technologies, translational efforts and dedicated mentorship have transformed the field.

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“…[51][52][53] The process has been used for cosmetic skin resurfacing for a number of years 49 but has also been investigated for enhancing the penetration of topically applied substances. 2,54 Skin abrasion has been shown to enhance the skin delivery of a range of hydrophilic molecules (caffeine, 48 acyclovir, 48 5 -fl uorouracil (5 -FU), 50 vitamin C, 55 5 -aminolevulinic acid 56 ), small peptides (angiotensin II, 48 MW 1046 Da), FITC -labeled dextrans 47 (4.3, 9.6, 42.0 kDa), and vaccines. 57,58 The ability to enhance transdermal delivery is highlighted in Figure 3.4 , showing delivery of sodium fl uorescein through microdermabraded monkey skin and no penetration through untreated skin.…”

Section: Skin Abrasionmentioning

confidence: 99%